Dermal Cell News Volume 3.09 | Mar 20 2017

TOP STORY

Multiepitope Tissue Analysis Reveals SPPL3-Mediated ADAM10 Activation as a Key Step in the Transformation of Melanocytes

Researchers analyzed protein expression profiles (PEPs) in nevi and BRAF^V600E-positive superficial spreading melanomas (SSMs) from patient tissues to identify key transformation events. The PEPs in nevi and SSMs differed predominantly in the abundance of specific antigens, but the PEPs of nevi- and melanoma-associated keratinocytes gradually changed during the transformation process. [Sci Signal] Abstract

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DERMAL STEM CELLS & TISSUE REGENERATION

GLI2 Is a Regulator of β-Catenin and Is Associated with Loss of E-Cadherin, Cell Invasiveness and Long-Term Epidermal Regeneration

Scientists provide evidence of HH/GLI2-WNT/β-catenin signaling crosstalk in human keratinocytes. Over-expression of GLI2ΔN in human keratinocytes resulted in cytoplasmic accumulation and nuclear relocalization of β-catenin in vitro and in 3D-organotypic cultures, accompanied by upregulation of WNT genes. [J Invest Dermatol] Abstract

Targeted Deletion of Crif1 in Mouse Epidermis Impairs Skin Homeostasis and Hair Morphogenesis

Keratinocyte proliferation and differentiation were markedly inhibited in Crif1 conditional knockout (cKO) mice. Furthermore, hair follicle morphogenesis of Crif1 cKO mice was disrupted by down-regulation of Wnt/β-catenin signaling. [Sci Rep] Full Article

TMF and Glycitin Act Synergistically on Keratinocytes and Fibroblasts to Promote Wound Healing and Anti-Scarring Activity

Co-treatment with 4′,6,7-trimethoxyisoflavone (TMF) and glycitin synergistically promoted the proliferation and migration of both keratinocytes and dermal fibroblasts, with a 1:1 ratio of these compounds showing the greatest efficacy in a co-culture system. [Exp Mol Med] Full Article

IRF6 Promotes Keratinocyte Differentiation in Response to Porphyromonas gingivalis

The authors established that interferon regulatory factor (IRF6) promotes the differentiation of oral keratinocytes in response to P. gingivalis. This was evidenced by the IRF6-dependent upregulation of specific markers of keratinocyte terminal differentiation, together with additional transcriptional regulators of keratinocyte differentiation, including Grainyhead-like 3 and Ovo-like zinc finger 1. [Infect Immun] Abstract

Cadmium, Lead, and Arsenic Contamination in Paddy Soils of a Mining Area and Their Exposure Effects on Human HEPG2 and Keratinocyte Cell-Lines

Cell viability decreased with increasing metal concentrations. Co-exposure to heavy metals (Pb+Cd) increased the metals (Pb or Cd)-mediated MT protein induction in both human HepG2 and KERTr cells. [Environ Res] Abstract

Effect of 5-Aminolevulinic Acid Photodynamic Therapy on Keratinocyte Proliferation and Apoptosis in Condyloma Acuminatum

The effect of 5-aminolevulinic acid photodynamic therapy on keratinocyte proliferation and apoptosis in condyloma acuminatum tissues was evaluated. [Photodiagnosis Photodyn Ther] Abstract

SKIN CANCERS & DISORDERS

Combined Regimen of Photodynamic Therapy Mediated by Gallium Phthalocyanine Chloride and Metformin Enhances Anti-Melanoma Efficacy

Scientists aimed to find the anti-melanoma efficacy of gallium phthalocyanine chloride-photodynamic therapy (PDT), assess possible beneficial effects of metformin addition to PDT, and uncover some of the mechanisms underlining cell killing and anti-angiogenic effects. [PLoS One] Full Article

Proteasome Inhibitors against Amelanotic Melanoma

Investigators analyzed the cytotoxicity mechanisms of proteasome inhibitors in a specific form of melanoma which does not synthesize melanin—the amelanotic melanoma. [Cell Biol Toxicol] Full Article

Nanotechnology for the Treatment of Melanoma Skin Cancer

The authors showed that the enhanced permeability and retention is the basis for using nanotechnology, aiming topical drug delivery. The importance of the detection of skin cancer in the early stages is directly related to non-metastatic effects and survival rates of melanoma cells. [Prog Biomater] Full Article

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MetrioPharm Announces Positive Top-Line Results from a Phase IIa Study in Moderate-to-Severe Psoriasis with its Oral Lead Compound MP1032

MetrioPharm AG announced positive top line results from its Phase IIa trial with its proprietary drug compound MP1032 in patients with moderate-to-severe plaque psoriasis. [MetrioPharm AG] Press Release

Asana BioSciences Announces FDA Acceptance of the IND Application for its Novel SYK-JAK Inhibitor for Evaluation in Atopic Dermatitis

Asana BioSciences, LLC. announced that the FDA has accepted the IND application for ASN002, a novel dual SYK-JAK inhibitor, for atopic dermatitis. [Asana BioSciences, LLC.] Press Release

Jailed Iranian Researcher’s Health Worsening Rapidly

An Iranian researcher jailed in Tehran for the last 11 months is in declining health after spending more than two months on hunger strike. This month, researchers around the world made urgent appeals for his release. [Nature News] Editorial

Trump’s NIH Budget May Include Reducing Overhead Payments to Universities

The Trump administration may be planning to help pay for a massive 18% cut to the National Institutes of Health (NIH) by slashing payments to universities and research institutes for overhead costs, ScienceInsider has learned. [ScienceInsider] Editorial

NEW Mouse Development, Stem Cells & Cancer
June 7-26, 2017
Cold Spring Harbor, United States

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NEW Professorships – Tissue Engineering and Regenerative Medicine (The Chinese University of Hong Kong)

NEW Postdoctoral Training Fellow – Aryl Hydrocarbon Receptor (The Francis Crick Institute)

NEW Postdoctoral Fellowship – Atopic Dermatitis (Boston Children’s Hospital)

NEW Postdoctoral Fellow – Immunology (Columbia University Medical Center)

Postdoctoral Scholarship – Skin Immunology (Karolinska Institute)

PhD Student Position – Skin Immunology (Karolinska Institute)

Junior Research Group Leader – Analytics and Toxicology (The Federal Institute for Risk Assessment)

Postdoctoral – Tumor Biology (Helmholtz Association)

Postdoctoral Position – Translational Melanoma (University of Gothenburg)

Bioinformatics Scientist – Cancer Biology (Genentech, Inc.)

Assistant Professor – Molecular Therapeutics of Cancer (Dartmouth College)

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