Dermal Cell News 3.13 April 17, 2017 | |
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TOP STORYMelanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response The authors mimicked epigenetic modifications in melanoma cells by reprogramming them into metastable induced pluripotent cancer cells (iPCCs) with the ability to terminally differentiate into non-tumorigenic lineages. Induction of a pluripotent state allowed the melanoma-derived cells to acquire a non-tumorigenic cell fate. [Stem Cell Reports] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONActomyosin Contractility Provokes Contact Inhibition in E-Cadherin-Ligated Keratinocytes Scientists report that among epithelial cells, keratinocytes, which compose the stratified epithelium in the skin, possess a unique, actomyosin-dependent mechanism for contact inhibition. They observed that under actomyosin-inhibited conditions, cell-cell contact itself through E-cadherin promotes proliferation of keratinocytes. [Sci Rep] Full Article The impact of methylparaben (MP), the most frequently used preservative in cosmetics, on human dermal fibroblasts and collagen production was evaluated. In cells treated with MP a dose-dependent decrease in collagen biosynthesis was revealed, which was positively correlated with the activity of prolidase responsible for the recovery of proline. Consequently, the concentration of total collagen secreted into the medium was markedly diminished. [J Appl Toxicol] Abstract The identity and temporal pattern of signals that regulate hair follicle dermal stem cell function are not known. Researchers showed that platelet-derived growth factor signaling is crucial for hair follicle dermal stem cell function and platelet-derived growth factor deficiency results in a progressive depletion of the hair follicle dermal stem cell pool and their progeny. [NPJ Regen Med] Full Article SKIN CANCERS & DISORDERSTime-Dependent Effect of Rutin on Skin Fibroblasts Membrane Disruption following UV Radiation Investigators aimed to determine the effects of natural, previously extensively examined, polyphenol with antioxidant properties – rutin, on ultraviolet (UV)-induced skin fibroblasts membrane disruption. Rutin penetration through the fibroblast phospholipid bilayer was aided by UVA-induced bilitranslocase activity after irradiation, while UVB irradiation led to enhanced phospholipid peroxidation and higher membrane permeability to facilitate the interaction of rutin with phospholipids. [Redox Biol] Full Article | Graphical Abstract Impact of BRAF Kinase Inhibitors on the miRNomes and Transcriptomes of Melanoma Cells To investigate the impact of BRAF inhibitors on miRNomes and transcriptomes, the authors used in vitro melanoma models consisting of BRAF inhibitor-sensitive and -resistant cell lines generated in the laboratory. Several miRNAs and genes were distinctly differentially expressed in drug-resistant versus -sensitive cell lines. [Biochim Biophys Acta] Abstract LncRNA CCAT1 Upregulates Proliferation and Invasion in Melanoma Cells via Suppressing miR-33a Scientists investigated the regulation of CCAT1 on melanoma genesis. Expression of CCAT1 was significantly up-regulated in melanoma tissue and cell lines. CCAT1 knockdown observably suppressed the proliferation, migration and invasion ability. [Oncol Res] Full Article Researchers searched for the possible cause of ultraviolet (UV)B-inhibited hyperplasia and UVB-resulted hyperproliferation. They evaluated whether the expression of Raf-1 kinase inhibitory protein (RKIP), inducible nitric oxide synthase (iNOS), nitric oxide (NO) and proliferation in keratinocytes at various UVB dose was affected. The results showed that RKIP, iNOS and NO of keratinocytes with UVB treatment was significantly higher than the control group. [Toxicol In Vitro] Abstract Investigators indicated that miR-150 specifically down-regulated expressed in psoriatic skin lesions, and could inhibit HaCaT cells and primary adult human keratinocytes’ proliferation in either normal or hypoxia conditions; by direct targeting, miR-150 could also regulate the expression of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor A (VEGFA). [PLoS One] Full Article CYFIP1 Is Directly Controlled by NOTCH1 and Down-Regulated in Cutaneous Squamous Cell Carcinoma Previous work uncovered the functional role of CYFIP1 in epithelial tumors as an invasion inhibitor. The authors investigated its role and expression mechanisms in squamous cell carcinoma (SCC). CYFIP1 expression was down-regulated in SCC and correlated inversely with histological differentiation of tumors. [PLoS One] Full Article Sphaeropsidin A (Sph A) is a fungal bioactive secondary metabolite shown to force melanoma cells to undergo apoptosis via cell volume dysregulation. Researchers studied its in vitro combination with cytotoxic chemotherapeutics in a rational manner. Combining Sph A with cisplatin improved its cytotoxic effects on melanoma cells in a synergistic manner. [Cancer Chemother Pharmacol] Abstract | |
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REVIEWSThe authors summarize the evidence that inhibition of ultraviolet B-induced skin tumor development by dietary grape seed proanthocyanidins is mediated by a multiplicity of coordinated effects including: (i) Promotion of the repair of damaged DNA by nuclear excision repair mechanisms, and (ii) DNA repair-dependent stimulation of the immune system following the functional activation of dendritic cells and effector T cells. [Semin Cancer Biol] Abstract Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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INDUSTRY NEWSKadmon Holdings, Inc. announced the publication of clinical data from its completed Phase II open-label clinical trial of KD025, its oral Rho-associated coiled-coil kinase 2 inhibitor, in patients with moderate to severe psoriasis. KD025 treatment improved clinical scores and skin pathology in psoriasis patients via concurrent modulation of the pro- and anti-inflammatory immune cell response. [Kadmon Holdings, Inc.] Press Release Dermata Therapeutics, LLC and Villani, Inc. announced they have entered into an exclusive global license agreement for Villani’s natural sponge product, to be developed by Dermata as a potential treatment for a variety of skin diseases. Dermata will have the exclusive worldwide rights to develop and commercialize Villani’s patented sponge-based product, with the first target being the treatment of moderate to severe acne vulgaris. [Dermata Therapeutics, LLC (PR Newswire Association LLC.)] Press Release Haus Bioceuticals announced that MetaDerm Heal & Prevent cream, a clinically-proven over-the-counter (OTC) therapeutic botanical treatment for psoriasis, has earned the National Psoriasis Foundation Seal of Recognition. This seal highlights OTC products that are proven to safely and effectively manage the symptoms of psoriasis. [Haus Bioceuticals (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSWith This New System, Scientists Never Have to Write a Grant Application Again Almost every scientist agrees: Applying for research funding is a drag. Writing a good proposal can take months, and the chances of getting funded are often slim. Funding agencies, meanwhile, spend more and more time and money reviewing growing stacks of applications. That’s why two researchers are proposing a radically different system that would do away with applications and reviews; instead scientists would just give each other money. [ScienceInsider] Editorial Joining the European Union Leads to Less Cross-Border Collaboration When the European Union expanded in the 2000s, it had a negative impact on scientific collaborations between researchers in new member countries and elsewhere, a study has found. [Nature News] Editorial
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EVENTSNEW Mitochondrial Biogenesis and Dynamics in Health, Disease and Aging NEW Cell Culture World Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellowship – Adipocytes in Melanoma (Memorial Sloan Kettering Cancer Center) Scientist – Cell Biology and Autoimmune Disease (Immunocore) Postdoctoral Fellow – Melanoma (Icahn School of Medicine at Mount Sinai) Postdoctoral Research Fellow – Skin Epigenetics (Boston University) Postdoctoral Fellow/Research Assistant – Psoriasis (University of California, Davis) Two Postdoctoral Positions – Melanoma (Moffitt Cancer and Research Institute) Clinical Research Fellow – Melanoma (CRUK Manchester Institute) Professorships – Tissue Engineering and Regenerative Medicine (The Chinese University of Hong Kong) Postdoctoral Training Fellow – Aryl Hydrocarbon Receptor (The Francis Crick Institute) Junior Research Group Leader – Analytics and Toxicology (The Federal Institute for Risk Assessment) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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