Dermal Cell News Volume 4.02 | Jan 22 2018

TOP STORY

Injury-Activated Glial Cells Promote Wound Healing of the Adult Skin in Mice

Using a mouse model of wound healing, combined with in vivo fate mapping, scientists showed that injury activates peripheral glia by promoting de-differentiation, cell-cycle re-entry and dissemination of the cells into the wound bed. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

Cell Autonomous Role of iASPP Deficiency in Causing Cardiocutaneous Disorders

Researchers developed cardiomyocyte-specific and keratinocyte-specific inhibitor of apoptosis stimulating p53 protein (iASPP)-deficient mouse models and showed that the cell-type specific loss of iASPP in cardiomyocytes or keratinocytes is sufficient to induce cardiac or cutaneous disorders, respectively. [Cell Death Differ] Abstract

Expression of Inflammasome Proteins and Inflammasome Activation Occurs in Human, but Not in Murine Keratinocytes

The authors demonstrated that murine keratinocytes do not activate inflammasomes in response to stimuli, which induce interleukin (IL)-1β and -18 secretion by human keratinocytes. Whereas murine keratinocytes produced caspase-1 and proIL-18, expression of the inflammasome proteins Nlrp1, Nlrp3, Aim2, Asc, and proIL-1β was, compared to human keratinocytes or murine dendritic cells, very low or even undetectable. [Cell Death Dis] Full Article

Cathelicidin-OA1, a Novel Antioxidant Peptide Identified from an Amphibian, Accelerates Skin Wound Healing

Cathelicidin-OA1 accelerated wound healing against human keratinocytes and skin fibroblasts in both time- and dose-dependent manners. [Sci Rep] Full Article

NB-UVB Irradiation Downregulates Keratin-17 Expression in Keratinocytes by Inhibiting the ERK1/2 and STAT3 Signaling Pathways

Researchers investigated the effect of narrow-band ultraviolet B (NB-UVB) irradiation on K17 expression and its signaling pathways. After exposure to NB-UVB irradiation, immortalized human keratinocytes were analyzed by flow cytometry, CCK-8 assays and transmission electron microscopy to examine proliferation. [Arch Dermatol Res] Abstract

SKIN CANCERS & DISORDERS

LIGHT-HVEM Signaling in Keratinocytes Controls Development of Dermatitis

Researchers showed that the tumor necrosis factor superfamily protein LIGHT is required for experimental atopic dermatitis, and LIGHT directly controlled keratinocyte hyperplasia, and production of periostin, a matricellular protein that contributes to the clinical features of atopic dermatitis, as well as other skin diseases such as scleroderma. [J Exp Med] Abstract

STIM1 Activation of Adenylyl Cyclase 6 Connects Ca²⁺ and cAMP Signaling during Melanogenesis

Scientists showed that the endoplasmic reticulum calcium sensor protein STIM1 (stromal interaction molecule 1) interacts with the plasma membrane-localized adenylyl cyclase 6 to govern melanogenesis. [EMBO J] Abstract | Graphical Abstract

Activation of G Protein-Coupled Estrogen Receptor Signaling Inhibits Melanoma and Improves Response to Immune Checkpoint Blockade

Selective G protein-coupled estrogen receptor activation in primary melanocytes and melanoma cells induced long-term changes that maintained a more differentiated cell state as defined by increased expression of well-established melanocyte differentiation antigens, increased pigment production, decreased proliferative capacity, and decreased expression of the oncodriver and stem cell marker c-Myc. [eLife] Full Article | Press Release

miR-137 Regulates Ferroptosis by Targeting Glutamine Transporter SLC1A5 in Melanoma

Investigators showed that miR-137 negatively regulates ferroptosis by directly targeting glutamine transporter SLC1A5 in melanoma cells. [Cell Death Differ] Full Article

Centriole Overduplication Is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma

The authors determined that the majority of centrosome amplification in melanoma can be attributed to centriole overduplication rather than cell doubling events. Since polo-like kinase 4 (PLK4) is the master regulator of centriole duplication, the hypothesis that PLK4 overexpression contributes to centriole overduplication was evaluated. [Mol Cancer Res] Abstract

Extracellular Matrix Contribution to Skin Wounds Re-Epithelialization

Under favorable conditions, epidermal regeneration begins within hours after injury and takes several days until the epithelial surface is intact due to reorganization of the basement membrane. Regeneration relies on numerous signaling cues and on multiple cellular processes that take place both within the epidermis and in other participating tissues. [Matrix Biol] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

Novartis New Data Reinforces Superiority of Cosentyx^® versus Stelara^® in Achieving Skin Clearance for Psoriasis Patients

Novartis announced results from the head-to-head CLARITY study demonstrating the superiority of Cosentyx^® compared to Stelara^® in delivering clear and almost clear skin in adults with moderate-to-severe plaque psoriasis at 12 weeks. [Novartis AG] Press Release

FDA Grants Fast Track Designation to Concert Pharmaceuticals’ CTP-543 for the Treatment of Alopecia Areata

Concert Pharmaceuticals, Inc. announced that the FDA has granted Fast Track designation for CTP-543, a novel, oral Janus kinase inhibitor for the treatment of moderate-to-severe alopecia areata, an autoimmune disorder in which the immune system attacks hair follicles, resulting in patchy or complete hair loss. [Concert Pharmaceuticals, Inc.] Press Release

European Commission Approves Bristol-Myers Squibb’s Yervoy (Ipilimumab) for Treatment of Pediatric Patients 12 Years and Older with Unresectable or Metastatic Melanoma

Bristol-Myers Squibb Company announced that the European Commission has expanded the indication of Yervoy to include treatment of advanced melanoma in pediatric patients 12 years of age and older. [Bristol-Myers Squibb Company] Press Release

U.S. Scientists Breathe a Sigh of Relief as Government Shutdown to End

It’s over—at least for the moment. The U.S. Senate voted 81–18 to advance legislation funding government activities, essentially ending a partial government shutdown that had moved into its third day. The House of Representatives is expected to follow suit, sending the bill to President Donald Trump for his signature. [ScienceInsider] Editorial

Online Tool Calculates Reproducibility Scores of PubMed Papers

A new online tool measures the reproducibility of published scientific papers by analyzing data about articles that cite them. The software comes at a time when scientific societies and journals are alarmed by evidence that findings in many published articles are not reproducible and are struggling to find reliable methods to evaluate whether they are. [ScienceInsider] Editorial

India’s Education Minister Assails Evolutionary Theory, Calls for Curricula Overhaul

A new front has opened in the war on science in India. India’s minister for higher education, Satyapal Singh, took aim at the theory of evolution. Calling himself “a responsible man of science,” Singh, a chemist, suggested that Darwin’s theory is “scientifically wrong” and “needs to change” in school and university curricula. [ScienceInsider] Editorial

NEW Annual Meeting of the Israel Stem Cell Society 2018
May 31, 2018
Tel Aviv, Israel

Visit our events page to see a complete list of events in the community.

NEW Senior Research Associate – Melanoma, Skin and the UV Response (Lancaster University)

NEW Postdoctoral Fellow – Microbiology & Immunology (Johns Hopkins University)

Pioneer Award Postdoctoral Fellowships – Melanoma (University of Miami)

PhD or Postdoctoral Position – Tissue Repair, Stem Cell Fate and Tumor Heterogeneity (Université Libre de Bruxelles)

PhD Studenship – Skin Cancer (University of Salzburg)

Professor – Dermatology and Venereology (Karolinska Institutet)

Postdoctoral Positions – Gene Regulation and/or Cancer Biology (University of North Carolina)

Research Assistant – Melanoma Medical Oncology (MD Anderson Cancer Center)

Postdoctoral Associate – Melanoma (University of Miami)

Faculty Positions – Cancer and Stem Cell Biology (Sun Yat-Sen University)

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