Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News| Dermal Cell News 4.12 April 9, 2018 | |
 | |
| |
TOP STORYGlutamate Transporter Slc1a3 Mediates Inter‐Niche Stem Cell Activation during Skin Growth The authors reported that in mouse skin, hair growth is accompanied by sebaceous gland and interfollicular epidermis expansion. [EMBO J] Abstract | Graphical Abstract | |
| |
| |
PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONResearchers performed Cre-loxP-mediated cell fate tracking and revealed the fates of major population of regenerative epidermis cells that express fibronectin 1b during zebrafish fin regeneration. [Development] Abstract Scientists revealed that hypoxic conditions stimulate endogenous and exogenous Foxn1 expression in cultured keratinocytes. [Sci Rep] Full Article Investigators established epithelial-specific S100A2 transgenic mice and studied its role in wound repair using punch biopsy wounding assays. [Sci Rep] Full Article SKIN CANCERS & DISORDERSInvestigators compared induction of antioxidant enzymes and DNA damage responses in melanocytic cells of defined melanocortin 1 receptor gene genotype. [Oncogene] Abstract Targeting MDMX and PKCδ to Improve Current Uveal Melanoma Therapeutic Strategies Scientists showed that specifically depleting protein kinase C delta (PKCδ) inhibits uveal melanoma cell growth, which can be further enhanced by p53 reactivation. [Oncogenesis] Full Article Researchers indicated that in mice, UVB exposure increased susceptibility to carcinogens, and accelerated disease pathogenesis. Juglanin ameliorated this condition via inhibition of inflammation, suppression of cell proliferation and induction of apoptosis via p38/c-Jun N-terminal kinase blockage, nuclear factor κB inactivation and caspase stimulation in vivo. [Int J Mol Med] Abstract | Download Full Article To elucidate mechanistic insights into drug resistance, the authors established an in vitro cellular model of mitogen activated protein kinase inhibitor resistance in malignant melanoma. [BMC Syst Biol] Full Article | Press Release Selective Deletion of PPARβ/δ in Fibroblasts Causes Dermal Fibrosis by Attenuated LRG1 Expression Investigators uncovered a downregulated gene, leucine-rich alpha-2-glycoprotein-1 (Lrg1), of previously unknown function in skin development and architecture. [Cell Discov] Full Article | |
| |
| |
REVIEWSExtracellular Matrix as a Regulator of Epidermal Stem Cell Fate The authors summarize the remarkable progress that has recently been made in the research of extracellular matrix role in regulating epidermal stem cell fate, paying special attention to the hair follicle stem cell niche. [Int J Mol Sci] Full Article Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
| |
SCIENCE NEWSRXi Pharmaceuticals to Present an Update on Its Clinical and Cosmetic Dermatology Programs RXi Pharmaceuticals Corporation announced that it will present new data from the company’s dermatology franchise. [Press release from RXi Pharmaceuticals discussing research to be presented at the 7th International Investigative Dermatology (IID) Meeting 2018, Orlando] Press Release AVITA Medical Announces Schedule for Six RECELL® Device Presentations AVITA Medical announced new data to be presented describing clinical and cost-savings advantages of RECELL® device in the treatment of severe burns. [Press release from Avita Medical discussing research to be presented at the 2018 American Burn Association (ABA) 50th Annual Meeting, Chicago] Press Release | |
| |
INDUSTRY NEWSEMA to Review Cemiplimab as a Potential Treatment for Advanced Cutaneous Squamous Cell Carcinoma Regeneron Pharmaceuticals, Inc. and Sanofi announced that the European Medicines Agency (EMA) has accepted for review the Marketing Authorization Application for cemiplimab for the treatment of patients with metastatic cutaneous squamous cell carcinoma (CSCC) or patients with locally advanced CSCC who are not candidates for surgery. [Regeneron Pharmaceuticals, Inc.] Press Release Incyte Corporation and Merck announced that an external Data Monitoring Committee review of the pivotal Phase III ECHO-301/KEYNOTE-252 study results evaluating Incyte’s epacadostat in combination with Merck’s KEYTRUDA® in patients with unresectable or metastatic melanoma determined that the study did not meet the primary endpoint of improving progression-free survival in the overall population compared to KEYTRUDA monotherapy. [Merck & Co., Inc.] Press Release Menlo Therapeutics Inc. announced top-line results from MTI-103, the Phase II clinical trial of serlopitant for the treatment of pruritus in adults and adolescents with a history of atopic dermatitis. [Menlo Therapeutics Inc.] Press Release | |
| |
POLICY NEWSUK Survey Reveals Widespread Sexual Misconduct by Academic Staff A survey of current and former UK students has found that 41% experienced sexual misconduct – such as inappropriate comments, unwanted touching or assault – by staff at university. [Nature News] Editorial Unnecessary Exclusions Shut Patients out of Clinical Trials The FDA will hold a public meeting in Washington to discuss issues related to clinical trial eligibility criteria. Researchers, study sponsors, patients, and the general public will have an opportunity to share their experiences and tell our regulators why it’s time to revisit the guidelines. [STAT News] Editorial Cutting-Edge Cancer Drug Hobbled by Diagnostic Test Confusion A landmark cancer drug approved last year seemed to herald a long-anticipated change in the treatment of some tumors: with medicines selected on the basis of molecular markers, rather than the tissue in which the cancer first took root. But clinicians and researchers are struggling to put that theory into practice. [Nature News] Editorial China Asserts Firm Grip on Research Data In a move few scientists anticipated, the Chinese government has decreed that all scientific data generated in China must be submitted to government-sanctioned data centers before appearing in publications. At the same time, the regulations call for open access and data sharing. [ScienceInsider] Editorial French Say ‘No Deal’ to Springer as Journal Fight Spreads Research institutions, first in Germany and now in France, are finding that publishers do not cut off access to journals – even when they stop paying. [Times Higher Education] Editorial
| |
EVENTSNEW LabRoots: 2nd Annual Cell Biology Virtual Event Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Postdoctoral Researcher – Melanoma (Ghent University) NEW Postdoctoral Fellowship – Melanoma (The University of Texas, MD Anderson Cancer Center) NEW Associate Director – Oncology Outcomes Research (Merk) Postdoctoral Position – Melanoma (Massachusetts General Hospital) Academic Dermatopathologist – Non-Melanoma Skin Cancer (Harvard Medical School) Postdoctoral Research Associate – Melanoma (University of North Texas Health Science Center) Postdoctoral Position – Epidermal Development and Differentiation (National Institutes of Health) Postdoctoral Associate – Biomedical Engineering (University of Minnesota) Postdoctoral Fellow – Cancer Research (Indiana University School of Medicine) PhD Position – Melanoma (University of Luxembourg) Faculty Positions – Cancer and Stem Cell Biology (Sun Yat-Sen University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Dermal Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|
