Dermal Cell News 4.13 April 16, 2018 | |
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TOP STORYAn Evolutionarily Conserved Ribosome-Rescue Pathway Maintains Epidermal Homeostasis The authors showed that pelota (Pelo) is required for mammalian epidermal homeostasis. Conditional deletion of Pelo in mouse epidermal stem cells that express Lrig1 resulted in hyperproliferation and abnormal differentiation of these cells. [Nature] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONAbnormal Scar Identification with Spherical-Nucleic-Acid Technology Scientists showed that imaging nanoprobes for the live-cell detection of intracellular mRNA (also known as NanoFlares) enable measurements of the expression of connective tissue growth factor as a visual indicator of hypertrophic scars and keloids. [Nat Biomed Eng] Abstract Scientists investigated the effect of (1E,2E)-1,2-bis((6-bromo-2H-chromen-3-yl)methylene)hydrazine (BMM), a novel synthetic material, on the migration and viability of keratinocytes or fibroblasts using the in vitro scratch wound healing, electric cell-substrate imedance sensing, invasion, and MTT assays. [Int J Mol Sci] Full Article Blocking Negative Effects of Senescence in Human Skin Fibroblasts with a Plant Extract Researchers identified an extract from the plant Solidago virgaurea subsp. alpestris, which exhibited weak senolytic activity, delayed the acquisition of a senescent phenotype and induced a papillary phenotype with improved functionality in human dermal fibroblasts. [NPJ Aging Mech Dis] Full Article SKIN CANCERS & DISORDERSCancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade Scientists identified a subcluster of MAGE-A cancer-germline antigens, located within a narrow 75 kb region of chromosome Xq28, that predicts resistance uniquely to blockade of CTLA-4, but not PD-1. [Cell] Abstract | Graphical Abstract | Press Release Gene expression analysis of human melanoma cell lines and patient tumors revealed that melanoma follows a two-dimensional differentiation trajectory that can be subclassified into four progressive subtypes. [Cancer Cell] Abstract | Graphical Abstract | Press Release Investigators showed that IL-25, which is highly expressed in the lesional skin of psoriasis patients, was regulated by IL-17 in murine skin of a imiquimod-induced psoriasis model. [Immunity] Abstract | Graphical Abstract T Cell-Induced CSF1 Promotes Melanoma Resistance to PD1 Blockade Scientists showed that colony-stimulating factor 1 (CSF1) is expressed in human melanoma, and patients with metastatic melanoma have increased CSF1 in blood compared to healthy subjects. [Sci Transl Med] Full Article | Press Release Epigenetic Control of IL-23 Expression in Keratinocytes Is Important for Chronic Skin Inflammation Researchers showed that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation with an IL-17 profile. [Nat Commun] Full Article Co‐Targeting BET and MEK as Salvage Therapy for MAPK and Checkpoint Inhibitor‐Resistant Melanoma Investigators showed that BET proteins are overexpressed in NRAS‐mutant melanoma and that high levels of the BET family member BRD4 are associated with poor patient survival. [EMBO Mol Med] Full Article | Graphical Abstract | Press Release The authors showed Wnt5a signaling regulates acyl protein thioesterase 1 (APT1) activity through induction of APT1 phosphorylation and further investigated the functional role of APT1 phosphorylation on its depalmitoylating activity. [Elife] Abstract FOXP3 Expression Is Modulated by TGF-β1/NOTCH1 Pathway in Human Melanoma Researchers investigated transforming growth factor-β (TGF-β)-induced forkhead box protein 3 (FOXP3) gene expression during NOTCH1 signaling inactivation. [Int J Mol Med] Abstract | |
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REVIEWSInstructive Microenvironments in Skin Wound Healing: Biomaterials as Signal Releasing Platforms The authors describe the current state of the different signal cues used in wound healing and skin regeneration, and their combination with biomaterial supports to create instructive microenvironments for wound healing. [Adv Drug Deliv Rev] Abstract | Graphical Abstract Nanocoatings for Chronic Wound Repair—Modulation of Microbial Colonization and Biofilm Formation Researchers review the pathogenesis of chronic wounds, the role of chronic wound colonization and infection in the healing process, the conventional and alternative topical therapeutic approaches designed to combat infection and stimulate healing, as well as revolutionizing therapies such as nanotechnology-based wound healing approaches. [Int J Mol Sci] Full Article Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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SCIENCE NEWSPersonalis, Inc. to Present New Data Personalis, Inc., announced that the company will present four posters. [Press release from Personalis Inc discussing research to be presented at the 2018 American Association for Cancer Research (AACR), Chicago] Press Release AVITA Medical announced that results from a pivotal clinical trial demonstrating the effectiveness and clinical benefits of the RECELL® Autologous Cell Harvesting Device in the treatment of deep partial-thickness (second-degree) burns were presented. [Press release from Avita Medical discussing research presented at the American Burn Association (ABA) 50th Annual Meeting, Chicago] Press Release | |
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INDUSTRY NEWSDal-Led Project Awarded $3.2 Million to Develop New Immunotherapy Drugs for Advanced Melanoma A Dalhousie Medical School cancer immunologist has received a rare five-year operating grant from the U.S. NIH’s National Cancer Institute, in the amount of $3.2 million (CAD). The researchers have created photo-sensitive ruthenium metal-based compounds that can be applied to melanoma lesions on the skin. When activated by a specific wavelength of light, these compounds kill melanoma cells and, in the process, “teach” the immune system to recognize and eliminate metastatic cancer cells circulating in the body. [Dalhousie University] Press Release Merck and the European Organisation for Research and Treatment of Cancer (EORTC), announced findings from the Phase III EORTC1325/KEYNOTE-054 trial investigating KEYTRUDA®, Merck’s anti-PD-1 therapy, as adjuvant therapy in resected, high-risk stage III melanoma. [Merck & Co., Inc] Press Release XBiotech Announces Upcoming Phase II Clinical Studies in Dermatology XBiotech Inc. announced that it would evaluate a new subcutaneous formulation of the company’s True Human™ monoclonal antibody, MABp1, in two separate Phase II, open label, dose escalation studies in patients with moderate to severe atopic dermatitis and hidradenitis suppurativa. [XBiotech] Press Release | |
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POLICY NEWSSpain’s Biggest-Ever Science Petition Decries ‘Abandonment’ of Research Leading Spanish scientific organizations delivered a petition signed by more than 277,000 people to the national parliament in Madrid, calling on the government to stop the “progressive abandonment of science in Spain” caused by budget cuts. The petition is the largest ever on a science-policy subject in Spain. [Nature] Editorial A new report from the National Academies of Sciences, Engineering, and Medicine calls for a series of substantial reforms to strengthen the U.S. biomedical research system for the next generation of scientists. It urges Congress to establish a public-private partnership to promote collective and sustained stewardship of the biomedical research enterprise, and to consider increasing the budget of the National Institutes of Health to enable it to more robustly support early career researchers. [National Academy of Sciences] Editorial A Final Dash Across the United States: Updates from the 2018 March for Science The March for Science celebrated its anniversary. And although the turnout around the world was significantly smaller than last year, supporters haven’t lost any of their energy. [ScienceInsider] Editorial Adding a Citizenship Question to the 2020 Census Would Be Disastrous for Public Health The Trump administration’s eleventh-hour decision to add a question about citizenship to the census will almost certainly have a major chilling effect among immigrants. One expert predicts that as many as 24 million people would not be counted as a result of adding this question. This would sabotage the census, seriously compromise vital public health research, and ultimately damage the public’s health. [STAT News] Editorial
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EVENTSNEW LabRoots: 6th Annual Cancer Research & Oncology Virtual Event Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellowships – Melanoma (Sylvester Comprehensive Cancer Center) NEW Director – Melanoma Global Value Evidence Leader (Merck) Postdoctoral Researcher – Melanoma (Ghent University) Postdoctoral Fellowship – Nanosystem Development for Skin Cancer Therapeutics (University of Tours) Postdoctoral Fellowship – Melanoma (The University of Texas, MD Anderson Cancer Center) Associate Director – Oncology Outcomes Research (Merk) Postdoctoral Position – Melanoma (Massachusetts General Hospital) Academic Dermatopathologist – Non-Melanoma Skin Cancer (Harvard Medical School) Postdoctoral Research Associate – Melanoma (University of North Texas Health Science Center) Postdoctoral Position – Epidermal Development and Differentiation (National Institutes of Health) Postdoctoral Associate – Biomedical Engineering (University of Minnesota) PhD Position – Melanoma (University of Luxembourg) Faculty Positions – Cancer and Stem Cell Biology (Sun Yat-Sen University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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