Dermal Cell News 4.14 April 23, 2018 | |
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TOP STORYElectrophilic Properties of Itaconate and Derivatives Regulate the IκBζ-ATF3 Inflammatory Axis Investigators showed that itaconate and dimethyl itaconate induce electrophilic stress, react with glutathione and subsequently induce both Nrf2 (also known as NFE2L2)-dependent and -independent responses. [Nature] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONScientists examined the role of extracellular matrix stiffness on human keratinocyte behavior using elastomeric substrates with defined mechanical properties. [J Cell Sci] Abstract The authors evaluated the changes in 11β-hydroxysteroid dehydrogenase type I and barrier function under psychological stress. [Sci Rep] Full Article Several beneficial effects on the skin have been reported for coumestrol (COU), such as protection against photoaging and improvement of skin elasticity and thickness in postmenopausal women. The present study was designed as a two-step experiment to evaluate the wound healing effect of COU. [Eur J Pharm Sci] Abstract | Graphical Abstract Researchers aimed at characterizing the response of human dermal fibroblast subpopulations to visible and near‐infrared light in an attempt to identify the optical treatment parameters with high potential to address deficits in aging skin and non‐healing chronic wounds. [Lasers Surg Med] Abstract SKIN CANCERS & DISORDERSAlthough glucose transport in keratinocytes is mediated largely by the Glut1 facilitative transporter, the authors found that keratinocyte-specific ablation of Glut1 did not compromise mouse skin development and homeostasis. [Nat Med] Abstract Homeobox A9 (HOXA9), a direct target of onco-miR-365, is identified to be significantly downregulated in cutaneous squamous cell carcinoma tumors and cell lines. [Nat Commun] Full Article Mutated MITF-E87R in Melanoma Enhances Tumor Progression via S100A4 Scientists identified calcium-binding protein S100A4, as a downstream target of microphthalmia-associated transcription factor MITF-E87R. [J Invest Dermatol] Abstract Amino Acid Signature in Human Melanoma Cell Lines from Different Disease Stages Researchers investigated acetate, pyruvate and the amino acid composition of the secretome of human melanoma cells representing the early slow and metastatic fast growth phase in order to identify possible signaling components within these profiles. [Sci Rep] Full Article KCNQ1OT1 Promotes Melanoma Growth and Metastasis The authors investigated the molecular mechanisms of long non-coding RNA KCNQ1OT1 in melanoma. [Aging (Albany NY)] Full Article | |
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REVIEWSEngineering Pro-Regenerative Hydrogels for Scarless Wound Healing The authors focus on recent advances in scarless wound healing, especially strategies to engineer pro‐regenerative scaffolds to restore damaged skin in a regenerative manner. [Adv Healthc Mater] Abstract Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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SCIENCE NEWSCheckmate Pharmaceuticals Presents Clinical Data Checkmate Pharmaceuticals announced the first presentation of data from an ongoing Phase Ib study evaluating CMP-001, Checkmate’s toll like receptor 9 agonist, in combination with pembrolizumab (KEYTRUDA®), an anti-PD-1 therapy, in patients with advanced melanoma resistant to prior anti-PD-1 checkpoint inhibition. [Press release from Checkmate Pharmaceuticals discussing research presented at the 2018 American Association for Cancer Research (AACR) Annual Meeting, Chicago] Press Release Elios Therapeutics, presented initial open-label results from the ongoing Phase IIb clinical trial of the TLPLDC (tumor lysate, particle-loaded, dendritic cell) vaccine in patients with stage III and IV (resected) melanoma. [Press release from Elios Therapeutics (PR Newswire Association LLC.) discussing research presented at the 2018 American Association for Cancer Research (AACR) Annual Meeting, Chicago] Press Release Castle Biosciences, Inc., announced presentation of results demonstrating that the use of the DecisionDx®-Melanoma gene expression profile test with American Joint Committee on Cancer (AJCC) staging can improve accuracy of recurrence and metastasis risk for patients with localized cutaneous melanoma. [Press release from Castle Biosciences, Inc., discussing research presented at the 3rd Annual Real World Dermatology for Physician Assistants and Nurse Practitioners Conference, Orlando] Press Release | |
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INDUSTRY NEWSCU Anschutz Scientists Awarded $3.8 Million DOD Grant Scientists from the Gates Center for Regenerative Medicine at the University of Colorado School of Medicine are part of a consortium awarded $3.8 million from the U.S. Department of Defense (DOD) to move discoveries in stem cell-created skin grafts into the manufacturing stage, bringing further hope to victims of debilitating inherited skin diseases. [The Regents of the University of Colorado] Press Release During its annual Spring Gala, the American Skin Association Chairman, Howard P. Milstein, announced the Abby S. and Howard P. Milstein Innovation Award for Melanoma/Non-Melanoma Skin Cancer Research. [American Skin Association] Press Release Mercy Medical Center Announces Opening of Melanoma & Skin Cancer Center Mercy Medical Center has announced the opening of The Melanoma and Skin Cancer Center at Mercy. The Center offers comprehensive care and leading edge treatment options for skin cancers including advanced-stage melanoma. [Mercy Medical Center (Newswise, Inc)] Press Release | |
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POLICY NEWSThe Salk Institute for Biological Studies has placed prominent cancer and gene therapy scientist Inder Verma on administrative leave and launched an investigation into allegations against him. [ScienceInsider] Editorial Women Less Successful When Applying for Patents Women inventors have less success than men at each step of the patent application process in the U.S., according to a study published this month in Nature Biotechnology. [The Scientist] Editorial Dutch Universities, Journal Publishers Agree on Open-Access Deals Despite some difficult negotiations, academic institutions in the Netherlands have been securing subscriptions that combine publishing and reading into one fee. [The Scientist] Editorial African Scientists Call for More Control of Their Continent’s Genomic Data Africa-based researchers issued guidelines for the ethical handling of samples for genomic studies. The voluntary rules are an effort to combat ‘helicopter’ research, in which foreign scientists take samples and data from communities and then return to their home institutions. [Nature News] Editorial
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EVENTSNEW European Society for Medical Oncology (ESMO) 2018 Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral/Research Scientist – Cancer Metabolism (Wake Forest Comprehensive Cancer Center) NEW Postdoctoral Fellow – Skin Cancer Research (University of Pennsylvania) Postdoctoral Fellowships – Melanoma (Sylvester Comprehensive Cancer Center) Director – Melanoma Global Value Evidence Leader (Merck) Postdoctoral Researcher – Melanoma (Ghent University) Postdoctoral Fellowship – Nanosystem Development for Skin Cancer Therapeutics (University of Tours) Postdoctoral Fellowship – Melanoma (The University of Texas, MD Anderson Cancer Center) Associate Director – Oncology Outcomes Research (Merk) Postdoctoral Position – Melanoma (Massachusetts General Hospital) Academic Dermatopathologist – Non-Melanoma Skin Cancer (Harvard Medical School) Postdoctoral Research Associate – Melanoma (University of North Texas Health Science Center) Postdoctoral Position – Epidermal Development and Differentiation (National Institutes of Health) Postdoctoral Associate – Biomedical Engineering (University of Minnesota) PhD Position – Melanoma (University of Luxembourg) Faculty Positions – Cancer and Stem Cell Biology (Sun Yat-Sen University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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