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Pulmonary Cell News| Dermal Cell News 4.28 August 20, 2018 | |
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TOP STORYHoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration Researchers showed that a single Hoxc gene was sufficient to activate dormant mesenchymal dermal papilla niches and promoted regional hair follicle regeneration through canonical Wnt signaling. [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONMacrophage Ferroportin Is Essential for Stromal Cell Proliferation in Wound Healing Genetic deletion of ferroportin in macrophages resulted in iron deficiency and decreased proliferation in epithelial cells, which consequently impaired hair follicle growth and caused transient alopecia. Inactivation of macrophage ferroportin also led to delayed skin wound healing with defective granulation tissue formation and diminished fibroplasia. [Haematologica] Abstract | Full Article Epidermal and dermal layers were developed using keratinocytes and fibroblasts differentiated from cord blood-derived human induced pluripotent stem cells, respectively. A complex 3D skin organoid was generated by overlaying the epidermal layer onto the dermal layer. A humanized skin model was generated by transplanting this human skin organoid into SCID mice and effectively healed skin lesions. [Stem Cell Res Ther] Full Article SKIN CANCERS & DISORDERSA Protective Langerhans Cell–Keratinocyte Axis that Is Dysfunctional in Photosensitivity Investigators showed that the absence of Langerhans cell (LC) in Langerin–diphtheria toxin subunit A mice led to photosensitivity and that, in vitro, mouse and human LCs could directly protect keratinocytes from ultraviolet radiation-induced apoptosis. [Sci Transl Med] Abstract | Press Release Gene expression profiling analysis identified both an upregulation of FOXD1 in neural crest and melanoma cells, as well as a downregulation of several genes related to cell invasion in FOXD1 knockdown cells, including MMP9 and RAC1B. Knockdown of RAC1B, a tumor-specific isoform of RAC1, significantly impaired melanoma cell migration and invasion and could abrogate enhanced invasiveness induced by FOXD1 overexpression. [Int J Cancer] Abstract Suppression of IGF1R in Melanoma Cells by an Adenovirus-Mediated One-Step Knockdown System Annexin V-FITC flow cytometry assay, immunofluorescence staining for cleaved Caspase3, and hoechst staining showed that more cells underwent apoptosis after infection with human or mouse siRNAs targeting IGF1R (AdRIGF1R-OK). Luciferase reporter assay, crystal violet cell viability assay, and cell cycle analysis showed that the proliferation of melanoma cells infected with AdRIGF1R-OK was significantly decreased compared to the controls. [Mol Ther Nucleic Acids] Abstract | Full Article Scientists provided evidence that targeting a cryptic region of the extracellular matrix protein collagen (HU177 epitope) inhibited melanoma tumor growth and metastasis and reduced angiogenesis and the accumulation of αSMA-expressing stromal cells in these tumors. Melanoma cell interactions with the HU177 epitope promoted nuclear accumulation of Yes-associated protein (YAP) by a cyclin-dependent kinase-5 (CDK5) associated mechanism. [Am J Pathol] Abstract Except for 32ins24 mutant melanocytes, the remaining cultures from different CDKN2A mutation carriers showed no detectable aberrations in proliferation or capacity for replicative senescence. The latter cultures responded normally to ultraviolet radiation (UV) by cell cycle arrest, JNK, p38, and p53 activation, hydrogen peroxide generation, and repair of DNA photoproducts. [Pigment Cell Melanoma Res] Abstract Coexpression of Xiphophorus cdkn2ab in medaka transgenic for the mitfa:xmrk melanoma inducing gene resulted in full suppression of melanoma development, whereas CRISPR/Cas9 knock-out of cdkn2ab resulted in strongly enhanced tumor growth. [Pigment Cell Melanoma Res] Abstract By activity-guided phytochemical investigation of the extracts from G.uralensis root, ten flavonoids, namely GF-1-GF-10, of which five were prenylated flavonoids, were found to show antiproliferative effects in melanoma B16-F10 cells. [Int J Mol Sci] Full Article | Graphical Abstract Role of IL-17A Receptor Blocking in Melanocytes Survival: A Strategic Intervention against Vitiligo The expression of MITF and its downstream genes after blocking with anti-IL-17RA, an increased melanin content, increased expression of TYR, MITF along with its downstream genes, and cell proliferation was observed. [Exp Dermatol] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cancer Stem Cell News. | |
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REVIEWSThe Potential of Human Induced Pluripotent Stem Cells for Modeling Diabetic Wound Healing In Vitro Generation of induced pluripotent stem cells (iPSCs) from tissues donated by diabetic patients allows the (epi)genetic background of this disease to be studied, and the ability to differentiate iPSCs to multiple cell types found within skin may facilitate the development of more complex skin models. [Clin Sci (Lond)] Abstract Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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INDUSTRY NEWSRealm Therapeutics Reports Top-line Data from Phase II Trial of PR022 in Atopic Dermatitis Realm Therapeutics PLC reported preliminary top-line data from its Phase II trial of PR022 in atopic dermatitis. In a randomized, double-blind, vehicle controlled, Phase II clinical trial of 122 patients, PR022 showed no difference from vehicle in the primary endpoint of percent change in Eczema Area Severity Index versus baseline. [Realm Therapeutics PLC] Press Release Novan Announces Promising Clinical Results with SB414 Novan, Inc. announced an update on the SB414 nitric oxide-releasing cream product candidate and its application to two therapeutic indications: atopic dermatitis and psoriasis. [Novan, Inc.] Press Release | |
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POLICY NEWSSalk Institute Asks Judge to Narrow Scope of Gender-Discrimination Suit Lawyers representing the Salk Institute for Biological Studies went to court on 17 August in San Diego, California, asking a judge to narrow the scope of a gender-discrimination lawsuit filed by molecular biologist Beverly Emerson. [Nature News] Editorial Prominent Health Policy Researcher Plagiarized Colleagues’ Work, Dartmouth Investigation Finds A Dartmouth College investigation has concluded that Dr. H. Gilbert Welch, one of the country’s most prominent health care policy scholars, committed research misconduct in connection with a paper published in a top medical journal. [STAT News] Editorial
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EVENTSNEW Tumor Immunology and Immunotherapy Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research /Senior Scientist – Modeling & Simulation (Certara) Post-doctoral Positions – Cancer Genetics/Genomics (University of Pennsylvania) Post-Doctoral Scientist – Novel T Cell Based Cancer Therapies (Netherlands Cancer Institute) Associate Professorships – Regenerative Medicine (University of Pavia) Associate Professor or Professor – Skin Cancer (The University of Texas M.D. Anderson Cancer Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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