Dermal Cell News 4.35 October 22, 2018 | |
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TOP STORYScientists genetically labeled Lgr5- or Lgr6-expressing cells from the hair follicle bulge and interfollicular epidermis, respectively, and monitored their individual transcriptional adaptations during wound healing using single-cell transcriptomics. [Cell Rep] Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONMicro-CT analysis revealed that the porosity of electrospun scaffolds was enhanced from 61% to 79% with 30 parts of PDMS addition. Moreover, MTT assay and cell proliferation were studied using human skin fibroblast cells and found to be significantly enhanced with the PDMS percentage. [J Biomed Mater Res B Appl Biomater] Abstract Extracellular Proteoglycan Decorin Maintains Human Hair Follicle Stem Cells In vitro experiments with human plucked hair-derived hair follicle stem cells (HFSCs) revealed that HFSCs lost their undifferentiated state with increasing passages, and prior to this change a decrease in extracellular matrix proteoglycan decorin expression was observed. [J Dermatol] Abstract SKIN CANCERS & DISORDERSUsing the epidermis as an experimental model with the RNA sequencing approach, researchers identified a novel p63-regulated gene induced during differentiation, ZNF185. [Oncogene] Full Article Scientists applied multiplex phosphoproteomic profiling across a panel of 24 melanoma cell lines with different disease-relevant mutations, to predict responsiveness to MEK inhibitor trametinib. [Cell Death Differ] Abstract Potential Risk to Human Skin Cells from Exposure to Dicloran Photodegradation Products in Water The application of dicloran irradiated with simulated sunlight for 4 hours or 1,4-benzoquinone significantly delayed the migration of keratinocytes in monolayer cell sheets, inhibited keratinocyte differentiation, increased the production of pro-inflammatory molecules by 3D keratinocyte culture, and enhanced the ability of 3D cultured keratinocytes in the activation of co-cultured dermal fibroblast cells. [Environ Int] Abstract | Graphical Abstract Loss of GRHL3 Leads to TARC/CCL17-Mediated Keratinocyte Proliferation in the Epidermis The authors identified thymus and activation-regulated chemokine (TARC) as a novel soluble chemokine mediator of keratinocyte proliferation following loss of transcription factor Grainyhead-like 3 (GRHL3). [Cell Death Dis] Full Article Repeated dose treatment of the anti-epithelial growth factor receptor (EGFR)-antibody cetuximab showed increased pro-apoptotic related gene expression in the tumor microtissues. [Sci Rep] Full Article Lidocaine-Induced Potentiation of Thermal Damage in Skin and Carcinoma Cells Researchers demonstrated that cancer cell lines showed significantly increased cell toxicity when a moderate temperature and low lidocaine concentrations were combined. [Lasers Surg Med] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cancer Stem Cell News. | |
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REVIEWSPluripotent Stem Cell-Derived Cochlear Cells: A Challenge in Constant Progress The authors provide an overview of the molecular mechanisms involved in hair cell production from both human and mouse embryonic stem cells. [Cell Mol Life Sci] Abstract Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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SCIENCE NEWSNovartis announced a new data analysis of COMBI-AD, a Phase III multi-center study evaluating dabrafenib in combination with trametinib in stage III adjuvant resected BRAF V600-mutant melanoma. [Press release from Novartis AG discussing research presented at the European Society of Medical Oncology conference, Munich] Press Release Merck announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a positive opinion recommending approval of KEYTRUDA, Merck’s anti-PD-1 therapy, as adjuvant therapy in the treatment of patients with melanoma with lymph node involvement who have undergone complete surgical resection. [Press release from Merck & Co., Inc. discussing research presented at the American Association for Cancer Research Annual Meeting 2018 , Chicago] Press Release | |
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INDUSTRY NEWSCorbus Pharmaceuticals Holdings, Inc. announced continued favorable safety and tolerability profiles and further improvement in efficacy outcomes in open-label extensions of lenabasum Phase II studies in two rare and serious autoimmune diseases, systemic sclerosis and dermatomyositis. [Corbus Pharmaceuticals Holdings, Inc.] Press Release Bristol-Myers Squibb Company announced four-year data from the Phase III CheckMate -067 clinical trial which continues to demonstrate durable, long-term survival benefits with the first-line combination of nivolumab and ipilimumab, versus ipilimumab alone, in patients with advanced melanoma. [Bristol-Myers Squibb Company] Press Release | |
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POLICY NEWSBritish Universities Set Up European Outposts As Brexit Looms Some of Britain’s leading research institutions are establishing alliances with counterparts in other European countries — a move that might allow them to keep drawing on the EU’s science funds even in the case of a ‘no-deal’ divorce from the bloc, a more extreme form that Brexit could take. [Nature News] Editorial UK’s Science Reputation ‘At Risk If Academic Visa Issues Not Resolved’ The Wellcome Trust, which grants more than £1bn for research each year, said the immigration system was “not up to scratch” after another scientific summit in the UK was marred by the visa barriers delegates and speakers faced. [The Guardian] Editorial
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EVENTSNEW International Society for Stem Cell Research (ISSCR) 2019 Annual Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Wound Healing (Louisiana State University) NEW Postdoctoral Fellow – Biomaterials and Tissue Regeneration (University of Otago) Postdoctoral Position – Translational Skin Cancer Research (German Cancer Research Center DKFZ) Group Leader – Organoid Modeling of Disease (European Molecular Laboratory) Assistant Professor – Department of Biomedical Engineering (Boston University) Associate Researcher – Inflammatory Skin Diseases (Icahn School of Medicine at Mount Sinai) Postdoctoral Fellow – Skin Cancer (Stanford University School of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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