Dermal Cell News 4.40 December 3, 2018 | |
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TOP STORYMyofibroblast Proliferation and Heterogeneity Are Supported by Macrophages during Skin Repair Researchers examined myofibroblast subsets in different cutaneous fibrotic contexts and explored mechanisms that selectively promoted the expansion of adipocyte precursor cells. [Science] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONScientists identified that activation of the Sonic hedgehog pathway reinstalled a regenerative dermal niche, called dermal papilla, which was required and sufficient for hair follicle neogenesis. [Nat Commun] Full Article In vitro bioactivity of fibers on human gingiva fibroblast cells was evaluated by MTT assay. The polycaprolactone-gelatin/lawsone 1% increased cell attachment and proliferation significantly. [Int J Biol Macromol] Abstract | Graphical Abstract Investigators used an in vitro model to study the anti-tyrosinase, tolerogenic, and anti-melanogenic effects of sericin on Staphylococcus aureus peptidoglycan-stimulated melanocytes, dendritic cells, and artificial skin. [Biol Res] Full Article SKIN CANCERS & DISORDERSScientists found that C-C chemokine receptor 5 (CCR5) was more abundant in melanoma cells than normal cells and was positively associated with tumor malignancy in clinical patients. [J Pathol] Abstract Inhibition of MERTK Promotes Suppression of Tumor Growth in BRAF Mutant and BRAF Wild-Type Melanoma In melanoma cell lines, treatment with UNC2025 potently inhibited phosphorylation of MERTK and downstream signaling, induced cell death, and decreased colony formation. [Mol Cancer Ther] Abstract Researchers identified sphingosine-1-phosphate receptors as regulators of BRAFV600E-mutant melanoma cell-autonomous resistance to BRAF inhibitors (BRAFi). [Mol Cancer Ther] Abstract In two melanoma cell lines, which greatly differed in chemosensitivity and radiosensitivity, trehalose significantly inhibited short-term cell proliferation and also enhanced ionizing radiation-induced cytostasis. [J Cell Physiol] Abstract Mechanism of miR-137 Regulating Migration and Invasion of Melanoma Cells by Targeting PIK3R3 Gene Knockdown of miR-137 significantly reduced the migrated and invasive abilities of melanoma cells. Moreover, inhibition of PIK3R3 obviously suppressed the migration and invasion abilities of melanoma cells. [J Cell Biochem] Abstract Hypoxia exposure aggravated melanoma cell invasion, migration, vasculogenic mimicry and epithelial-mesenchymal transition (EMT). During this process, leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) expression was also decreased. [Biosci Rep] Abstract Wedelolactone Suppresses Cell Proliferation and Migration through AKT and AMPK Signaling in Melanoma Scientists treated melanoma cell line cells with wedelolactone and monitored the cell proliferation, invasion and migration, the mRNA and protein levels of Bax and Bcl-2, expression of cell-cycle regulators including cyclin D, proliferating cell nuclear antigen and p21. [J Dermatolog Treat] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cancer Stem Cell News. | |
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REVIEWSThe Itch-Scratch Cycle: A Neuroimmune Perspective The authors highlight recent advances in the understanding of the neuroimmunology of chronic itch centered around three key points of entry into the itch-scratch cycle: the epithelial barrier, the immune system, and the peripheral nervous system. [Trends Immunol] Full Article Biofilms in Chronic Wounds: Pathogenesis and Diagnosis Investigators briefly summarize the mechanism of biofilm formation and focus on current diagnostic approaches of chronic wound biofilms based on morphology, microbiology, and molecular assays. [Trends Biotechnol] Abstract Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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INDUSTRY NEWSTargeting Scar-Free Wound Healing – ERC Consolidator Grant Awarded to Yuval Rinkevich Dr. Yuval Rinkevich’s work will now be supported by a Consolidator grant from the European Research Council (ERC) providing around two million euros of research funding over the next five years. [Helmholtz Zentrum München] Press Release PolarityTE, Inc. announced that its skin regeneration product, SkinTEâ„¢, has been named as a finalist in the Fierce Innovation Awards Life Science Edition 2018 in the Biotech Innovation category. [PolarityTE, Inc.] Press Release FDA Clears SpinalCyte IND Application for Universal Donor Cell Therapy to Treat Lower Back Pain SpinalCyte, LLC announced the FDA has cleared its Investigational New Drug (IND) protocol for human trials in the U.S., considered to be the first IND approval for a fibroblast cell therapy in a chronic condition outside of dermatological uses. [SpinalCyte, LLC] Press Release The purpose of the feasibility trial is to obtain FDA approval for a full clinical trial, which can lead to indications as a treatment for third-degree burn wounds, as well as for the fish-skin product to be used as a temporary cover for such wounds. [Kerecis] Press Release | |
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POLICY NEWSAcademics and industry have teamed up to oppose a move to broaden the range of research data that must be made publicly available, ahead of a key vote in the European Parliament. [Science Business] Editorial Does Science Have a Bullying Problem? A spate of bullying allegations have rocked several high-profile science institutions. Here’s how researchers, universities, funders and others are dealing with the issue. [Nature News] Editorial
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EVENTSNEW 15th Annual Stem Cell Symposium: Stem Cells B2B – Bench to Bedside Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellowship – Skin Biology (Karolinska Institutet) Assistant Professor of Pediatrics – Dermatology (Harvard Medical School) Tenure Faculty – Cancer Biology (University of Chicago) Assistant Professor – Cancer Biology (University of Pennsylvania) Postdoctoral Researcher – Skin Epithelial Stem Cells (University of Michigan) Senior Researcher – Skin Biology (University of Pennsylvania) Postdoctoral Fellowships – Nanomedicine and Biomedical Engineering (University of British Columbia) Postdoctoral Fellow – Dermatooncology (German Cancer Research Center) Postdoctoral Fellow – Wound Healing (Louisiana State University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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