Dermal Cell News Volume 5.01 | Jan 14 2019

TOP STORY

Sensitivity to Splicing Modulation of BCL2 Family Genes Defines Cancer Therapeutic Strategies for Splicing Modulators

While BCL2A1, BCL2L2 and MCL1 were prone to splicing perturbation, BCL2L1 exhibited resistance to E7107-induced splicing modulation. Consequently, E7107 selectively induced apoptosis in BCL2A1-dependent melanoma cells and MCL1-dependent NSCLC cells. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

Human Novel MicroRNA Seq-915_x4024 in Keratinocytes Contributes to Skin Regeneration by Suppressing the Inflammatory Response and TGF-β1/Smad Signaling Pathway-Induced Scar Formation

Using an in vitro wound healing assay, transwell cell migration assay and MTS proliferation assay, researchers demonstrated that keratinocytes overexpressing seq-915_x4024 exhibited higher proliferative activity and the ability to promote fibroblast migration and fibroblast proliferation. [Mol Ther Nucleic Acids] Abstract

Sanshool Improves UVB-Induced Skin Photodamage by Targeting JAK2/STAT3-Dependent Autophagy

Scientists determined the photoprotective effect of sanshool, a major component in Zanthoxylum bungeanum, on UVB-irradiated responses in human dermal fibroblasts and nude mouse. [Cell Death Dis] Full Article

BLNCR Is a Long Non-Coding RNA Adjacent to Integrin Beta-1 That Is Rapidly Lost during Epidermal Progenitor Cell Differentiation

Researchers characterized the expression of 26 long non-coding RNAs in human epidermal keratinocytes, seven of which were found to be dynamically expressed during differentiation. [Sci Rep] Full Article

Connexin43 Mutations Linked to Skin Disease Have Augmented Hemichannel Activity

Investigators used two different functional expression systems to characterize three Cx43 mutations linked to palmoplantar keratoderma and congenital alopecia-1, erythrokeratodermia variabilis et progressiva, or inflammatory linear verrucous epidermal nevus. [Sci Rep] Full Article

1-(2-Hydroxyethyl)-2-Imidazolidinone, a Heparanase and Matrix Metalloproteinase Inhibitor, Improves Epidermal Basement Membrane Structure and Epidermal Barrier Function

1-(2-hydroxyethyl)-2-imidazolidinone inhibited not only basement membrane damage at the DEJ but also epidermal proliferation, differentiation, water content and transepidermal water loss abnormalities resulting from ultraviolet B. [Exp Dermatol] Abstract

Antioxidant-Antibacterial Containing Bi-Layer Scaffolds as Potential Candidates for Management of Oxidative Stress and Infections in Wound Healing

The bi-layer scaffold accelerated the process of wound healing with no inflammatory cells, proliferation of fibroblast, neovascularization and collagen deposition. [J Mater Sci Mater Med] Abstract

SKIN CANCERS & DISORDERS

Increased Lactate Dehydrogenase Activity Is Dispensable in Squamous Carcinoma Cells of Origin

Researchers sought to determine whether lactate dehydrogenase activity in squamous cell carcinoma was critical for tumorigenesis or simply a marker of the cell type of origin. [Nat Commun] Full Article | Press Release

Heme Oxygenase 1 Facilitates Cell Proliferation via the B-Raf-ERK Signaling Pathway in Melanoma

Histology and co-immunoprecipitation showed that HO-1 interacted with B-Raf directly in melanoma tissue. Further study illustrated that HO-1 overexpression promoted melanoma cell proliferation while HO-1 reduction repressed melanoma cell proliferation because of HO-1 affecting the cell cycle. [Cell Commun Signal] Full Article

Translational Control Mechanisms in Cutaneous Malignant Melanoma: The Role of eIF2α

Investigators evaluated levels and localization of eIF2α/peIF2α in V600BRAF and wtBRAF metastatic melanoma cell lines by means of western blot and confocal microscopy analyses. [J Transl Med] Full Article

Akazamicin, a Cytotoxic Aromatic Polyketide from Marine-Derived Nonomuraea sp

Activity-guided purification led to the isolation of a new aromatic polyketide, akazamicin (1), along with two known compounds, actinofuranone C (2) and N-formylanthranilic acid (3). Structures of these compounds were elucidated through the interpretation of NMR and MS spectroscopic data. Compounds 1, 2, and 3 displayed cytotoxicity against a murine B16 melanoma cell line. [J Antibiot (Tokyo)] Abstract

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Potential Use of Melatonin in Skin Cancer Treatment: A Review of Current Biological Evidence

The authors discuss how melatonin may improve outcomes in skin cancer patients. [J Cell Physiol] Abstract

Epigenetic Control in Skin Development, Homeostasis and Injury Repair

Investigators draw a comprehensive picture of how epigenetic modifiers orchestrate their cell-intrinsic role with microenvironmental cues for proper skin development, homeostasis, and wound repair. [Exp Dermatol] Abstract | Full Article

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

US FDA sets PDUFA date for SCENESSE^®

CLINUVEL PHARMACEUTICALS LTD announced that the FDA Division of Dermatology and Dental Products has set a Prescription Drug User Fee Act (PDUFA) date of 8 July 2019. [CLINUVEL PHARMACEUTICALS LTD] Press Release

Biofrontera Receives FDA Approval for Upscaling of Batch Size for Ameluz^® Production

Biofrontera AG announced that the FDA, and earlier the European Medicines Agency, have approved the upscaling of the batch size for the production of Ameluz^® to 35 kg from previously 7 kg. [Biofrontera AG (GlobeNewswire, Inc.)] Press Release

Open-Access Row Prompts Editorial Board of Elsevier Journal to Resign

The editorial board of an influential scientometrics journal — the Journal of Informetrics — has resigned in protest over the open-access policies of its publisher, Elsevier, and launched a competing publication. [Nature News] Editorial

If the Shutdown Drags on at FDA, It Will Put Anticipated New Treatments in Jeopardy

The government shutdown could soon jeopardize highly anticipated new drugs from Janssen, Sanofi and Novartis for depression, diabetes and multiple sclerosis, as well as a host of other potential new therapies, according to a STAT analysis of upcoming regulatory decision dates. [STAT News] Editorial

NEW Gordon Research Conference: Neural Crest & Cranial Placodes
April 14-19, 2019
Lucca, Italy

Visit our events page to see a complete list of events in the community.

NEW PhD Student – Cell Biology (Universitatsklinikum Munster)

Postdoctoral Associate – Pathology (Stony Brook University)

PhD Studentship – Melanoma (University of Otago)

Research Fellow – Stem Cell Biology (Brigham & Women’s Hospital)

Postdoctoral Position – Pluripotent Stem Cells (I-STEM)

Professor – Dermatological Oncology (University of Tubingen)

Grant Program – Skin Disease Research (Brigham & Women’s Hospital and Harvard Medical School)

Tenure Faculty – Cancer Biology (University of Chicago)

Assistant Professor – Cancer Biology (University of Pennsylvania)

Postdoctoral Researcher – Skin Epithelial Stem Cells (University of Michigan)

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