Dermal Cell News 5.10 March 25, 2019 | |
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TOP STORYResearchers used a stem cells fate-mapping approach to examine the contribution of regulatory T (Treg) cells to epidermal-barrier repair after injury. Depletion of Treg cells impaired skin-barrier regeneration and was associated with a Th17 inflammatory response and failed hair-follicle stem cells differentiation. [Immunity] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONInstructive Role of Melanocytes during Pigment Pattern Formation of the Avian Skin Scientists observed that developing melanocytes directly connected with each other via filopodia to form a network in culture and in vivo. This melanocyte network was reminiscent of zebrafish pigment cell networks, where connexin was implicated in stripe formation via genetic studies. [Proc Natl Acad Sci USA] Abstract Keratinocyte Differentiation Promotes ER Stress-Dependent Lysosome Biogenesis By using primary neonatal human epidermal keratinocytes, investigators identified the molecular link between signaling pathways and cellular differentiation/lysosome biogenesis. Incubation of keratinocytes with CaCl2 induced differentiation with increased cell size and early differentiation markers. [Cell Death Dis] Full Article Direct Reprogramming of Epidermal Cells toward Sweat Gland-Like Cells by Defined Factors The authors showed that overexpression of the transcription factor FoxC1 was sufficient to reprogram epidermal cells to induced functional sweat gland-like cells (iSGCs). The iSGCs expressing secreting-related genes had a global gene expression profile between fetal SGCs and adult SGCs. [Cell Death Dis] Full Article SKIN CANCERS & DISORDERSUsing a human papillomavirus (HPV) 16 E7 variant that could inactivate retinoblastoma tumor suppressor but could not degrade PTPN14, investigators found that high-risk HPV E7-mediated PTPN14 degradation impairs keratinocyte differentiation. Deletion of PTPN14 from primary human keratinocytes decreased keratinocyte differentiation gene expression. [Proc Natl Acad Sci USA] Abstract The authors detected that bone morphogenetic protein-6 (BMP6) was significantly increased in skin-derived fibroblasts of patients with localized scleroderma. Moreover, it was shown that BMP6 significantly impacted proliferation, migration, cytoskeletal organization, and collagen expression as well as activity of the major pro-fibrogenic transcription factor AP-1 in dermal fibroblasts. [J Invest Dermatol] Abstract Researchers found that the absence of oncogenic transformation in hypoxia-inducible factor-1α-ablated mice was related to increased DNA repair in keratinocytes, while the formation of hyperkeratotic plaques was caused by an increase in the levels of reactive oxygen species. [J Invest Dermatol] Abstract Among down-regulated proteins in vemurafenib-resistant cell lines, investigators detected multiple proteins involved in cytoskeletal organization and signaling, including the intermediate filament nestin, which was one of the most down-regulated proteins. [Mol Cell Proteomics] Abstract | Full Article Resistant cells expressing the p53 gene presented a lower proliferation rate and increased expression levels of N-cadherin and Gsk3β than parental cells. In contrast, 10thG cells lacking the p53 gene showed lower levels of expression of Gsk3β in the cytoplasm and of E-cadherin and β-catenin in the membrane. [Sci Rep] Full Article While scientists observed only minimal effects of silicon dioxide nanoparticles (SiNPs) on healthy mouse skin, there was an immunomodulatory effect of these NPs in a model of allergic contact dermatitis. The effect appeared to be mediated partly by keratinocytes and resulted in decreases in epidermal hyperplasia, inflammatory cytokine release, immune cell infiltration, and a subsequent reduction in skin swelling. [Sci Rep] Full Article Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cancer Stem Cell News. | |
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REVIEWSChoreographing Immunity in the Skin Epithelial Barrier The authors discuss the context-specific signals that drive productive immune responses in the skin epithelium, highlighting key modulators of these reactions, including hair follicles, neurons, and commensal microbes. They also discuss the non-canonical functions of cutaneous immune cells, including their burgeoning role in epithelial regeneration and repair. [Immunity] Abstract Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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INDUSTRY NEWSDURECT Corporation announced it has commenced patient dosing in a Phase IIa proof-of-concept trial with topical DUR-928 in patients with mild to moderate plaque psoriasis. [DURECT Corporation] Press Release MatriSys Bioscience, Inc. announced it has successfully completed a pre-Investigational New Drug (IND) review with the FDA. The FDA provided positive feedback regarding the planned initiation of clinical trials for MSB-01 under a US IND for MatriSys’ lead microbiome-based candidate, MSB-01, for the treatment of atopic dermatitis. [MatriSys Bioscience, Inc. (GlobeNewswire, Inc.)] Press Release Biofrontera AG received positive preliminary results for the primary endpoint of its Phase III clinical trial evaluating the safety and efficacy of conventional photodynamic therapy with Ameluz® and the BF-RhodoLED® lamp for the treatment of actinic keratoses on the extremities as well as the trunk and neck. [Biofrontera AG (GlobeNewswire, Inc.)] Press Release Emerald Health Pharmaceuticals Inc. (EHP) announced that newly published scientific data supports the potential of EHP’s lead orally-administered drug candidate, EHP-101, to treat systemic sclerosis. a severe form of scleroderma. [Emerald Health Pharmaceuticals, Inc.] Press Release City of Hope Awarded $7.5 Million to Develop Better Treatment for a Rare, Incurable Cancer City of Hope recently received $7.5 million in grant awards to study a rare type of blood cancer that affects the skin: cutaneous T cell lymphoma (CTCL). The National Cancer Institute awarded two grants valued at $6.3 million over five years to City of Hope’s Steven Rosen, MD, and Christiane Querfeld, MD, PhD, so that they can develop improved therapies for CTCL. [City of Hope] Press Release | |
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POLICY NEWSScientists Among Thousands Marching to Demand Say on Brexit Scientists took to the streets of London on 23 March as part of a major demonstration calling for the terms of Brexit to be put to the British people in a vote. [Nature News] Editorial Chinese-American Scientist Societies Fear Racial Profiling In a strongly worded letter published in Science, a group of Chinese-American scientists voiced concern that recent proposals from the National Institutes of Health and FBI actions could lead to unjust targeting of ethnically Chinese scientists. [The Scientist] Editorial
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EVENTSNEW 5th CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellowship – Immune Cell-Mediated Regulation (Hospital for Special Surgery) NEW Junior Faculty and Postdoctoral Positions – Epigenetic Regulation (Henry Ford Health System) Postdoctoral Researcher – Skin Biology (University of Wisconsin-Madison) Director – Arthritis and Musculoskeletal and Skin Diseases (National Institutes of Health) Postdoctoral Scientist – Molecular Oncology (University of Manchester) Research Assistant – Burn Research (Sunnybrook Health Sciences Centre) Postdoctoral Positions – Wound Healing (University of California, Davis) PhD Position – Epidermal Tissue Mechanics (Forschungszentrum Jülich) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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