Dermal Cell News Volume 5.20 | Jun 10 2019

TOP STORY

Acyltransferase Skinny Hedgehog Regulates TGFβ-Dependent Fibroblast Activation in SSc

The expression of hedgehog acyltransferase was upregulated in dermal fibroblasts of patients with systemic sclerosis (SSc) in a transforming growth factor-β (TGFβ)/SMAD-dependent manner. [Ann Rheum Dis] Abstract

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

Upregulation of Long Non-Coding RNA MALAT1 Accelerates Wound Healing of Diabetic Mice Transfused with Modified Autologous Blood via the Activation of HIF-1α Signaling Pathway

Through gain- or loss-of-function approaches, viability of fibroblasts cultured in high glucose, wound healing of mice and collagen expression in wound areas were enhanced by metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and HIF-1α. [Mol Ther Nucleic Acids] Abstract | Full Article | Graphical Abstract

Developing Regulatory Property of Gelatin-Tannic Acid Multilayer Films for Coating-Based Nitric Oxide Gas Delivery System

The nitric oxide-releasing film was tested for its toxicity against human dermal fibroblast cells and bactericidal effects against Staphylococcus aureus. [Sci Rep] Full Article

Jarid1b Promotes Epidermal Differentiation by Mediating the Repression of Ship1 and Activation of the AKT/Ovol1 Pathway

Scientists showed that H3K4me3 was decreased during epidermal differentiation. The H3K4me3 demethylase Jarid1b positively controlled epidermal cell differentiation in vitro and in vivo. [Cell Prolif] Full Article

Interleukin-17 Receptor D Constitutes an Alternative Receptor for Interleukin-17A Important in Psoriasis-Like Skin Inflammation

Although interleukin-17 receptor C (IL-17RC) and IL-17RD differentially activated IL-17A-dependent signaling and gene expression, their compound mutation led to complete deficits in keratinocytes. [Sci Immunol] Full Article

SKIN CANCERS & DISORDERS

Role of MIA (Melanoma Inhibitory Activity) in Melanocyte Senescence

Induction of replicative or oncogene-induced senescence resulted in increased MIA expression in vitro. Notably, MIA-knockdown in senescent melanocytes reduced the percentage of senescence-associated beta-Gal-positive cells and enhanced proliferation. [Pigment Cell Melanoma Res] Abstract

Establishment of a Model of Sentinel Lymph Node Metastasis Using Immunodeficient Swine

A431 human epithelial carcinoma cells expressing green fluorescent protein were injected subcutaneously into the posterior sides of the auricle, forelimb and hindlimb of knockout swine. [Sci Rep] Full Article

LncRNA NEAT1 Facilitates Melanoma Cell Proliferation, Migration, and Invasion via Regulating miR-495-3p and E2F3

Investigators displayed that NEAT1 was overexpressed in melanoma cells. A series of functional assays showed that overexpression of NEAT1 promoted the proliferation, migration, and invasion of melanoma cells. [J Cell Physiol] Abstract

Embryonic Stem Cell Microenvironment Suppresses the Malignancy of Cutaneous Melanoma Cells by Down-Regulating PI3K/AKT Pathway

Researchers showed that, compared to the control group, A2058 cells in group one exhibited decreased cellular proliferation, migration, invasiveness and vasculogenic mimicry concomitant with an increase in cell apoptosis, accompanied by down-regulation of PI3K/AKT pathway. [Cancer Med] Full Article

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Adjuvant Treatment of Melanoma: Recent Developments and Future Perspectives

The authors summarize the current state of the field and describe new strategies tracing the history of adjuvant therapy in melanoma, with a view on future projects. [Am J Clin Dermatol] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

Lilly to Showcase Scientific Innovation within Dermatology Portfolio

Eli Lilly and Company will present data for Taltz^®, Olumiant^® and mirikizumab. [Press release from Eli Lilly and Company discussing research to be presented at the 24^th World Congress of Dermatology (WCD), Milan] Press Release

Athenex and PharmaEssentia Announce Positive Early Signals of Clinical Activity of KX2-391 (INN: Tirbanibulin) in Patients with Psoriasis

Athenex, Inc. and PharmaEssentia Corp. announced preliminary positive clinical activity signals observed in a cohort of patients with psoriasis treated with KX2-391 1% ointment once daily for five days in a Phase I clinical trial. [Athenex, Inc.] Press Release

Motif Bio Announces Path Forward for Iclaprim following Receipt of FDA Meeting Minutes

Motif Bio plc announced that the company has received the official minutes of the Type A meeting the Company held with the FDA on May 3, 2019, to discuss the points raised in the Complete Response Letter related to the New Drug Application for iclaprim, for the treatment of acute bacterial skin and skin structure infections. [Motif Bio plc] Press Release

Dermavant Sciences Announces First Patient Dosed in PSOARING, Its Pivotal Phase III Clinical Program for Tapinarof for the Topical Treatment of Plaque Psoriasis

Dermavant Sciences announced that the first patient has been dosed in its pivotal Phase III psoriasis clinical program, PSOARING, for its lead product candidate, tapinarof. Tapinarof is a therapeutic aryl hydrocarbon receptor modulating agent topical cream being developed by Dermavant for plaque psoriasis and atopic dermatitis. [Dermavant Sciences] Press Release

InflaRx Announces Top-Line SHINE Phase IIb Results for IFX-1 in Hidradenitis Suppurativa

InflaRx reported the top-line results of the international SHINE Phase IIb study, investigating the safety and efficacy of IFX-1, a first-in-class anti-human complement factor C5a monoclonal antibody, in patients suffering from moderate to severe hidradenitis suppurativa. [InflaRx N.V.] Press Release

Powerful US Senator Calls for Vetting NIH Grantees at Hearing on Foreign Influences

Research typically enjoys bipartisan support in the US Congress. But when it comes to the increasingly contentious topic of academic espionage by foreign governments, politics is never far from the surface. At a hearing of the Senate Committee on Finance, Chairman Chuck Grassley urged federal agencies to do more to thwart “real, aggressive, and ongoing” attempts by foreign entities to steal the fruits of US-funded research. [ScienceInsider] Editorial

Hungarians Protest against Proposed Government Takeover of Science

Thousands of scientists and their supporters marched through the streets of Budapest on 2 June to protest against a proposed law that would give the Hungarian government direct control of the country’s top research institutes. [Nature News] Editorial

NEW European Congress on Clinical and Translational Medicine (EUSTM)
October 18-20, 2019
Vienna, Austria

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellowship – Epithelial Growth in Development and Cancer (Fred Hutchinson Cancer Research Center)

NEW Research Fellowship – Melanoma (Dana-Farber Cancer Institute)

Director – Division of Extramural Research (National Institute of Arthritis and Musculoskeletal and Skin Diseases)

Postdoctoral Research Associate – Psoriasis and Atopic Dermatitis (King’s College London)

Scientist – Dermal Drug Discovery (Healx)

Postdoctoral Position – Cancer Epigenetics (Harvard University)

Faculty Positions – Allergy, Rheumatology or Skin Biology (University of Rochester)

Postdoctoral Position – Cell Biologist (IUF – Leibniz Research Institute for Environmental Medicine)

Postdoctoral Positions – Cell Competition (University of Bristol)

Faculty Positions – Skin Cancer (Columbia University)

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