Dermal Cell News Volume 5.28 | Aug 19 2019

TOP STORY

Inflammatory Activation of Astrocytes Facilitates Melanoma Brain Tropism via the CXCL10-CXCR3 Signaling Axis

Researchers found that CXCL10 was upregulated in metastasis-associated astrocytes in mice and humans and was functionally important for the chemoattraction of melanoma cells. [Cell Rep] Full Article | Graphical Abstract

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

Elevated Thrombospondin-2 Contributes to Delayed Wound Healing in Diabetes

Investigators explored whether the expression of thrombospondin-2, a matricellular protein with a demonstrated role in response to injury, was associated with delayed healing in diabetes. [Diabetes] Abstract

Exonic Mutations Associated with Atopic Dermatitis Disrupt LEKTI Action and Enhance Its Degradation

Scientists sought to determine whether lymphoepithelial Kazal‐type related inhibitor (LEKTI) exonic mutations associated with atopic dermatitis affected the protease inhibitory activity of LEKTI or its susceptibility to mesotrypsin degradation. [Allergy] Abstract

Morphological and Molecular Changes in Juvenile Normal Human Fibroblasts Exposed to Simulated Microgravity

The authors investigated juvenile normal human dermal fibroblasts grown in simulated microgravity on a random positioning machine, aiming to study changes in cell morphology, cytoskeleton, extracellular matrix, focal adhesion and growth factors. [Sci Rep] Full Article

Poly(D,L-lactide)/PEG Blend Films for Keratinocyte Cultivation and Skin Reconstruction

Investigators developed a novel porous thin poly(D,L-lactide) film as a tissue-engineering scaffold for keratinocytes used for the replacement of damaged skin. [Biomed Mater] Abstract

SKIN CANCERS & DISORDERS

Multiple Mechanisms of Rottlerin Toxicity in A375 Melanoma Cells

Researchers investigated the cytotoxic effects and mechanisms of rottlerin against human amelanotic A375 melanoma cells. [Biofactors] Abstract

High SLC7A11 Expression in Normal Skin of Melanoma Patients

Investigators quantified the expression of SLC7A11 and other genes that are involved in the synthesis of pheomelanin but do not regulate the transport of cysteine from the extracellular medium to the cytosol in non-tumorous skin of 45 patients of cutaneous melanoma and 50 healthy individuals. [Cancer Epidemiol] Abstract

Characterization of Phenolic Compounds and Antiproliferative Effects of Salvia pomifera and Salvia fruticosa Extracts

The effects of Salvia extracts and/or carnosic acid, the main diterpene phenolic component of S. fruticosa, on the proliferation and cell cycle of two melanoma cell lines and a human fibroblast cell line were investigated by MTT assay, PI-exclusion assay and flow cytometry cell cycle analysis. [Molecules] Full Article

MIM1 Induces COLO829 Melanoma Cells Death through Mitochondrial Membrane Breakdown, GSH Depletion and DNA Damage

Scientists examined the effect of MIM1 as well as MIM1 and dacarbazine mixture on cell viability, apoptosis and cell cycle progression in COLO829 melanoma cells. [Fundam Clin Pharmacol] Abstract

Circular RNA ITCH Downregulates GLUT1 and Suppresses Glucose Uptake in Melanoma to Inhibit Cancer Cell Proliferation

Researchers found that ITCH was downregulated in melanoma tissues and inversely correlated with GLUT1. ITCH overexpression resulted in the downregulation of GLUT1 and suppressed glucose uptake in melanoma. [J Dermatolog Treat] Abstract

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Characteristics and Roles of Extracellular Vesicles Released by Epidermal Keratinocytes

The authors provide an overview of the current literature and advances in the field of keratinocyte‐derived extracellular vesicle (EV) research with particular regard to the interactions and communication between keratinocytes and other skin cells, mediated by EVs and EV components. [J Eur Acad Dermatol Venereol] Abstract

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Lilly Announces Superiority of Taltz^® (Ixekizumab) versus TREMFYA^® (Guselkumab) in Delivering Total Skin Clearance at Week 12 in Topline Results from Head-to-Head (IXORA-R) Trial in People Living with Moderate to Severe Plaque Psoriasis

Eli Lilly and Company announced Taltz^® met the primary and all major secondary endpoints up to week 12 in the Phase IV IXORA-R study, which evaluated the efficacy and safety of Taltz versus TREMFYA^® in people living with moderate to severe plaque psoriasis. [Eli Lilly and Company] Press Release

RenovaCare Awarded New Patent Allowing for the Spray of Stem Cells for Regeneration of Organs and Tissues

RenovaCare, Inc. announced the issuance of a new patent allowing the company’s novel medical device to now spray all varieties of tissues and cells, thus opening the door for its potential application in the regeneration of tissues and organs, beyond skin. [RenovaCare, Inc.] Press Release

Head of Prestigious Ancient DNA Lab Suspended amid Bullying Allegations

The leader of Australia’s premier ancient DNA lab, Alan Cooper, has been suspended following a probe into the ‘culture’ of the center and amid allegations of bullying from his co-workers. Cooper is renowned for reconstructing how humans populated the planet using ancient DNA. [Nature News] Editorial

Hundreds of Extreme Self-Citing Scientists Revealed in New Database

A data set, which lists around 100,000 researchers, shows that at least 250 scientists have amassed more than 50% of their citations from themselves or their co-authors, while the median self-citation rate is 12.7%. The study could help to flag potential extreme self-promoters, and possibly ‘citation farms’, in which clusters of scientists massively cite each other, say the researchers. [Nature News] Editorial

In Departure for NIH, Cancer Moonshot Requires Grantees to Make Papers Immediately Free

In the United States, federal agencies have stuck to a decade-old policy that allows grantees to publish in journals that keep papers behind a paywall for up to one year. Now, the divide is starting to blur, with one prominent US research program starting to require immediate open access to the peer-reviewed publications it funds. [ScienceMagazine] Editorial

For a Decade, Francis Collins Has Shielded NIH—While Making Waves of His Own

Collins has helped shield National Institutes of Health (NIH) from threatened budget cuts as well as the upheaval that has shaken many other federal agencies under the Trump administration. [Nature News] Editorial

NEW Cell Death in Immunity and Inflamation
October 6-7, 2019
Crete, Greece

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NEW Research Associate Positions – Immunology and Inflammation (Imperial College London)

NEW Postdoctoral Research Scholar – Autoimmunity (University of California, Davis)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

NEW Student Biology – Cell Biology, Wound Healing, Gravitational Biology (German Aerospace Center)

Postdoctoral Fellowship – Gene Therapy of the Human Skin (The University of British Columbia)

Research Fellow – Dermatology (University College London)

Postdoctoral Position – Immune Mechanisms of Allergic Diseases (Boston Children’s Hospital)

Faculty Position – Melanoma and Skin Immunobiology (Medical College of Wisconsin)

Doctoral Candidate – Tattoo Inks (Federal Institute for Risk Assessment)

Postdoctoral Fellow – Cancer Drug Response Research (University of Texas at Austin)

Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California)

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