Dermal Cell News Volume 5.29 | Aug 26 2019

TOP STORY

Regulation of PRMT5-MDM4 Axis Is Critical in the Response to CDK4/6 Inhibitors in Melanoma

Scientists analyzed melanoma cells with acquired resistance to the cyclin-dependent kinase 4/6 (CDK4/6) inhibitor palbociclib and demonstrated that the activity of PRMT5, a protein arginine methyltransferase and indirect target of CDK4, was essential for CDK4/6 inhibitor sensitivity. [Proc Natl Acad Sci USA] Full Article

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

LSD1 Inhibition Promotes Epithelial Differentiation through Derepression of Fate-Determining Transcription Factors

Researchers showed that LSD1 directly repressed master epithelial transcription factors that promote differentiation. LSD1 inhibitors blocked both LSD1 binding to chromatin and its catalytic activity, driving significant increases in H3K4 methylation and gene transcription of these fate-determining transcription factors. [Cell Rep] Full Article | Graphical Abstract | Editorial

Maintenance of Melanocyte Stem Cell Quiescence by GABA-A Signaling in Larval Zebrafish

Investigators used CRISPR-Cas9 to generate two mutant alleles of gabrr1, a subtype of GABA-A receptors. Both alleles exhibited robust melanocyte overproduction, while conditional overexpression of gabrr1 inhibited larval melanocyte regeneration. [Genetics] Abstract

The Protective Role of Feruloylserotonin in LPS-Induced HaCaT Cells

The authors investigated the protective effects of feruloylserotonin on the keratinocyte with lipopolysaccharides (LPS)-induced human HaCaT cells and elucidated its underlying mechanisms of action. [Molecules] Full Article

SKIN CANCERS & DISORDERS

Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma

Scientists employed a genetic screening approach to identify gain-of-function mechanisms of BRAF inhibitor resistance in two independent melanoma cell lines. [Cancer Res] Abstract

The Dysfunction of BP180/Collagen XVII in Keratinocytes Promotes Melanoma Progression

Researcher used the B16 mouse melanoma model to demonstrate that BP180 dysfunction in either skin or basal keratinocytes promotes myeloid derived suppressor cell influx into skin and tumor progression. [Oncogene] Abstract

Classifying Melanoma by TERT Promoter Mutational Status

Using Sanger sequencing and qPCR-based techniques, the authors evaluated 60 melanoma cell lines for TERT promoter mutational status, copy number, gene expression, and telomere length in order to provide a comprehensive analysis of the TERT/telomere pathway and establish a classification system whereby the associations between TERT mutations and their downstream molecular manifestations can more easily be ascertained. [J Invest Dermatol] Abstract

Kalantuboside B Induced Apoptosis and Cytoprotective Autophagy in Human Melanoma A2058 Cells: An In Vitro and In Vivo Study

Researchers tested in vitro and in vivo anti-cancer efficacy with low concentrations of kalantuboside B (KB) on A2058 melanoma cells; and for the molecular mechanisms that underlie them. KB significantly inhibited the cell viability and colony formation via arresting the cell cycle at G2/M phase. [Free Radic Biol Med] Abstract | Graphical Abstract

Mcl-1 Inhibitor Induces Cells Death in BRAF-Mutant Amelanotic Melanoma Trough GSH Depletion, DNA Damage and Cell Cycle Changes

Investigators assessed the effect of MIM1 a specific low molecular Mcl-1 protein inhibitor and mixture of MIM1 and dacarbazine on the viability, cell cycle progression and apoptosis induction in amelanotic C32 melanoma cells. [Pathol Oncol Res] Full Article

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The Importance of the Neuro‐Immuno‐Cutaneous System on Human Skin Equivalent Design

It is critical to understand the connections and interplay between the peripheral nervous system and the skin and immune systems, the neuro‐immuno‐cutaneous system. Relevant in vitro tissue models based on human skin equivalents can be used to gain insight and to address impact across research and clinical needs. [Cell Prolif] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

Zylö and Hoth Therapeutics Forge Partnership to Develop Endocannabinoid-Based Drug to Treat Lupus

Zylö Therapeutics entered into a definitive partnership agreement with Hoth Therapeutics to develop a new treatment for patients suffering from Cutaneous Lupus Erythematosus, a chronic autoimmune disease that affects the skin. [Zylö Therapeutics (GlobeNewswire, Inc.)] Press Release

Steadman Philippon Research Institute Receives NIH Award for Research

The National Institutes of Health (NIH) has awarded Steadman Philippon Research Institute a grant to study the correlation between pregnancy and wound healing. [Steadman Philippon Research Institute] Press Release

More Than 700 German Research Institutions Strike Open-Access Deal with Springer Nature

A consortium of more than 700 German research institutions and libraries announced an agreement with publisher Springer Nature to make it simpler for authors to publish their papers open access. The agreement is the largest national open-access deal to date, but it doesn’t allow authors to publish open access in Nature or its sister journals. [ScienceInsider] Editorial

As Brexit Nears, Britain’s Drugs, Devices and Pricing Regulators Seek the Exit

Firm details on exactly how the UK will regulate new medicines is still to be decided after it leaves the EU later this year (caveats on timing abound), but we now know that the regulator won’t be run by Dr. Ian Hudson, who is stepping down after six years in charge. [FierceBiotech] Editorial

NEW Cancer Epigenetics: New Mechanisms and Therapeutic Opportunities
January 26-30, 2020
Keystone, Colorado, United States

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NEW Postdoctoral Research Fellow – Epithelial Growth in Development and Cancer (Fred Hutchinson Cancer Research Center)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Research Associate Positions – Immunology and Inflammation (Imperial College London)

Postdoctoral Research Scholar – Autoimmunity (University of California, Davis)

NEW Student Biology – Cell Biology, Wound Healing, Gravitational Biology (German Aerospace Center)

Postdoctoral Fellowship – Gene Therapy of the Human Skin (The University of British Columbia)

Postdoctoral Position – Immune Mechanisms of Allergic Diseases (Boston Children’s Hospital)

Faculty Position – Melanoma and Skin Immunobiology (Medical College of Wisconsin)

Doctoral Candidate – Tattoo Inks (Federal Institute for Risk Assessment)

Postdoctoral Fellow – Cancer Drug Response Research (University of Texas at Austin)

Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California)

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