Dermal Cell News Volume 5.30 | Sep 9 2019

TOP STORY

Priming Mobilization of Hair Follicle Stem Cells Triggers Permanent Loss of Regeneration after Alkylating Chemotherapy

Scientists established a permanent regeneration loss model using cycling human hair follicles treated with alkylating agents: busulfan followed by cyclophosphamide. They uncovered the underlying mechanisms by which hair follicle stem cells lose their pool. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

Lymphatic Vessels Interact Dynamically with the Hair Follicle Stem Cell Niche during Skin Regeneration In Vivo

Using steady and live imaging approaches in mouse skin, researchers showed that lymphatic vessels distributed to the anterior permanent region of individual hair follicles, starting from development through all cycle stages and interconnecting neighboring follicles at the bulge level, in a stem cell‐dependent manner. [EMBO J] Full Article | Graphical Abstract

Label-Free Stimulated Raman Scattering Microscopy Visualizes Changes in Intracellular Morphology during Human Epidermal Keratinocyte Differentiation

Investigators demonstrated label-free visualization of three-dimensional intracellular morphological changes of ex vivo human epidermis during epidermal keratinocyte differentiation using stimulated Raman scattering microscopy. [Sci Rep] Full Article

Photodynamic Therapy Using Zinc Phthalocyanine in Low Dose of Diode Laser Combined with Doxorubicin Is a Synergistic Combination Therapy for Human SK-MEL-3 Melanoma Cells

The combination of zinc phthalocyanine-photodynamic therapy and doxorubicin was applied at low and high doses of diode laser to treat SK-MEL-3 cells. Cytotoxic effects were determined by MTT assay for assessment synergistic effects were estimated by calculation of combination index; that synergistic effects were observed in most groups. [Photodiagnosis Photodyn Ther] Abstract | Graphical Abstract

SKIN CANCERS & DISORDERS

STING Signaling in Melanoma Cells Shapes Antigenicity and Can Promote Antitumor T-Cell Activity

The authors showed that intact activation of stimulator of IFN genes (STING) signaling in a subset of human melanoma cell lines enhanced both their antigenicity and susceptibility to lysis by human melanoma tumor infiltrating lymphocytes through the augmentation of MHC class I expression. [Clin Cancer Res] Abstract

Dacarbazine Alone or Associated with Melanoma‐Bearing Cancer Pain Model Induces Painful Hypersensitivity by TRPA1 Activation in Mice

Scientists investigated whether dacarbazine causes painful hypersensitivity in naïve or melanoma‐bearing mice and the involvement of transient receptor potential ankyrin 1 (TRPA1) in these models. [Int J Cancer] Abstract

Polyphenol-Rich Extract Induces Apoptosis with Immunogenic Markers in Melanoma Cells through the ER Stress-Associated Kinase PERK

The authors sought to elucidate the role that severe endoplasmic reticulum (ER) stress plays in mediating polyphenol-rich extract from Caesalpinia spinosa-induced apoptosis and immunogenic cancer cell death in murine melanoma cells. [Cell Death Discov] Full Article

Repurposing of the Anti-Helminthic Drug Niclosamide to Treat Melanoma and Pulmonary Metastasis via the STAT3 Signaling Pathway

Investigators evaluated the biological activities of niclosamide in melanoma in vitro and in vivo. Niclosamide potently inhibited the growth of four melanoma cell lines and induced the apoptosis of melanoma cells via the mitochondrial apoptotic pathway. [Biochem Pharmacol] Abstract | Graphical Abstract

YY1 Cooperates with TFEB to Regulate Autophagy and Lysosomal Biogenesis in Melanoma

Scientists found that Yin Yang 1 (YY1) regulated autophagy and lysosome biogenesis in melanoma cells. YY1 cooperated with transcription factor EB (TFEB) to regulate autophagy through controlling the transcription of autophagy and lysosome biogenesis related genes. [Mol Carcinog] Abstract

Physiologically Relevant Oxygen Concentration (6% O₂) as an Important Component of the Microenvironment Impacting Melanoma Phenotype and Melanoma Response to Targeted Therapeutics In Vitro

Using well-characterized patient-derived melanoma cell lines, researchers compared activities of several signaling pathways, and the effects of vemurafenib and trametinib in hyperoxia, normoxia and hypoxia. [Int J Mol Sci] Full Article

Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cancer Stem Cell News.

Risk Factors for the Development of Psoriasis

The authors summarize the risk factors, which can be divided into two groups (namely, extrinsic and intrinsic risk factors), responsible for the onset and exacerbation of psoriasis in order to facilitate its prevention. [Int J Mol Sci] Full Article

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

IMV Announces Research Collaboration with The Wistar Institute to Develop New Targeted Immunotherapy against the Common BRAF Cancer Mutation

IMV Inc. announced a collaboration with The Wistar Institute and Meenhard Herlyn, D.V.M., D.Sc., professor in the Molecular and Cellular Oncogenesis Program and director of Wistar’s Melanoma Research Center. [IMV Inc.] Press Release

Valo Therapeutics Acquires PeptiENV technology from the University of Helsinki

Valo Therapeutics Limited announced that it has licensed proprietary PeptiENV™ technology from Helsinki University that enables the coating of enveloped oncolytic viruses with tumor associated antigens. [Valo Therapeutics Limited] Press Release

Lipidor Announces Enrolment of Last Patient in Calcipotriol/AKVANO spray (AKP01) Phase III Study Targeting Psoriasis

Lipidor AB reported that the last patient has been enrolled in the ongoing Phase III study using calcipotriol spray against mild to moderate psoriasis. [Lipidor AB] Press Release

Melanoma Research Alliance Announces Nine Research Awards in Inaugural Class of Dermatology Fellows

In recognition of the critical role dermatologists can play in the prevention and early detection of melanoma, the Melanoma Research Alliance, the largest non-profit funder of melanoma research, today announced the inaugural cohort of nine dermatology research fellows. [Melanoma Research Alliance] Press Release

US Funding Scramble Leaves Science Agencies in Limbo

The US Congress has a busy few weeks in store. When lawmakers return from their summer break on 9 September, they’ll have just three weeks to hammer out a 2020 spending deal – and funding for the National Institutes of Health, National Science Foundation and other key science agencies is on the line. [Nature News] Editorial

Animal Registries Aim to Reduce Bias

Registries ask researchers to detail their hypotheses, experimental strategy and analytical plans before studies begin. The intention is to prevent teams from simply cherry-picking significant or desirable findings and to supply the scientific community with a way of learning about experiments that would otherwise go unpublished. [Nature News] Editorial

NEW Gene Regulation: From Mechanisms to Disease
January 26-30, 2020
Keystone, Colorado, United States

Visit our events page to see a complete list of events in the community.

NEW Faculty Positions – Cutaneous Oncology and Skin Cancer Research (Columbia University Medical Center)

NEW Postdoctoral Researcher – Cancer Research (Champalimaud Foundation)

NEW Postdoctoral Position – Cancer Immunology (Northwestern University Feinberg School of Medicine)

NEW Faculty Position – Cancer Biology (Children’s Research Institute at UT Southwestern)

NEW Faculty Position – Cancer Biology (Emory University)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Postdoctoral Research Fellow – Epithelial Growth in Development and Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Research Scholar – Autoimmunity (University of California, Davis)

Postdoctoral Fellowship – Gene Therapy of the Human Skin (The University of British Columbia)

Postdoctoral Position – Immune Mechanisms of Allergic Diseases (Boston Children’s Hospital)

Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Dermal Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.