Dermal Cell News Volume 5.31 | Sep 16 2019

TOP STORY

UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

Induction of UVB-derived mutations yielded highly aggressive tumors with decreased anti-tumor activity. However, single-cell-derived tumors with reduced intra-tumor heterogeneity were swiftly rejected. [Cell] Abstract | Press Release | Graphical Abstract

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

HNRNPK Maintains Epidermal Progenitor Function through Transcription of Proliferation Genes and Degrading Differentiation Promoting mRNAs

Researchers showed that HNRNPK, a multifunctional protein, was necessary to prevent premature differentiation and sustained the proliferative capacity of epidermal stem and progenitor cells. [Nat Commun] Full Article

Context-Dependent Effect of sPLA₂-IIA Induced Proliferation on Murine Hair Follicle Stem Cells and Human Epithelial Cancer

Investigators demonstrated that secretory phospholipase A₂-IIA (sPLA₂-IIA) induced rapid proliferation of hair follicle stem cells (HFSCs), thereby altering the proliferation dynamics leading to a complete loss of the slow cycling H2BGFP positive HFSCs. [EBioMedicine] Full Article

Telomere Dysfunction Impairs Epidermal Stem Cell Specification and Differentiation by Disrupting BMP/pSmad/P63 Signaling

The authors found that telomere shortening mediated by Terc loss up-regulated Follistatin, inhibiting pSmad signaling and down-regulating P63 and epidermal keratins in an ESC differentiation model as well as in adult development of telomere-shortened mice. [PLoS Genet] Full Article

On-Off Switching of Cell Cycle and Melanogenesis Regulation of Melanocytes by Non-Thermal Atmospheric Pressure Plasma-Activated Medium

Plasma-activated medium (PAM) promoted melanogenesis through the activation of the enzymes tyrosinase, tyrosinase-related protein-1, and tyrosinase-related protein-2. These effects seemed to be related to reactive oxygen species induced by PAM. [Sci Rep] Full Article

Ginkgolide B and Bilobalide Promote the Growth and Increase β-Catenin Expression in Hair Follicle Dermal Papilla Cells of American Minks

The administration of ginkgolide B (GKB) or bilobalide (BB) induced the growth of hair follicles. The viability of dermal papilla cells was also increased by GKB or BB as illustrated by methyl thiazolyl tetrazolium and flow cytometry detection. [BioFactors] Abstract

SKIN CANCERS & DISORDERS

B Cells Sustain Inflammation and Predict Response to Immune Checkpoint Blockade in Human Melanoma

Scientists showed that tumor associated B cells were vital to melanoma associated inflammation. Human B cells expressed pro- and anti-inflammatory factors and differentiated into plasmablast-like cells when exposed to autologous melanoma secretomes in vitro. [Nat Commun] Full Article | Press Release

Exosome-Mediated Uptake of Mast Cell Tryptase into the Nucleus of Melanoma Cells: A Novel Axis for Regulating Tumor Cell Proliferation and Gene Expression

Mechanistically, tryptase was found to be endocytosed by melanoma cells as cargo of DNA-coated exosomes released from melanoma cells, followed by transport to the nucleus. [Cell Death Dis] Full Article

Combining ERBB Family and MET Inhibitors Is an Effective Therapeutic Strategy in Cutaneous Malignant Melanoma Independent of BRAF/NRAS Mutation Status

Investigators explored novel treatment strategies using clinically approved drugs afatinib (ERBB family inhibitor) and crizotinib (MET inhibitor), to simultaneously block MET and ERBB family receptor tyrosine kinases. [Cell Death Dis] Full Article

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Potential of Curcumin in Skin Disorders

The authors examined the most relevant in vitro and in vivo studies published to date regarding the use of curcumin in inflammatory, neoplastic, and infectious skin diseases, providing information on its bioavailability and safety profile. [Nutrients] Full Article | Graphical Abstract

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Verrica Pharmaceuticals Submits New Drug Application to US Food and Drug Administration for VP-102 for the Treatment of Molluscum Contagiosum

Verrica Pharmaceuticals Inc. announced that it has submitted a New Drug Application to the FDA for VP-102, a proprietary topical therapy, for the treatment of molluscum contagiosum. [Verrica Pharmaceuticals, Inc.] Press Release

Akari Therapeutics’ Nomacopan Granted U.S. Orphan Drug Designation for Bullous Pemphigoid

Akari Therapeutics, Plc announced that the FDA has granted orphan drug designation for nomacopan for the treatment of bullous pemphigoid. [Akari Therapeutics, Plc] Press Release

Science under Maximum Pressure in Iran

From travel restrictions and publishing bans to currency collapse, the restoration of US sanctions has left researchers in Iran reeling. [The Scientist] Editorial

US EPA to Eliminate All Mammal Testing by 2035

The US Environmental Protection Agency (EPA) in Washington, DC, announced September 10^th that it will stop conducting or funding studies on mammals by 2035. The move, which is already eliciting strong reactions from groups supporting or opposing experiments on animals, makes EPA the first federal agency to put a hard deadline on phasing out animal research. [Science Magazine] Editorial

NEW NF-kB, JAK-STAT & MAPK in Health, Disease & Therapy
October 7-11, 2019
Suzhou, China

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NEW Postdoctoral Fellowship – Wound Healing and Tissue Regeneration (Memorial Sloan Kettering Cancer Center)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Faculty Positions – Cutaneous Oncology and Skin Cancer Research (Columbia University Medical Center)

Postdoctoral Researcher – Cancer Research (Champalimaud Foundation)

Postdoctoral Position – Cancer Immunology (Northwestern University Feinberg School of Medicine)

Faculty Position – Cancer Biology (Children’s Research Institute at UT Southwestern)

Faculty Position – Cancer Biology (Emory University)

Postdoctoral Research Fellow – Epithelial Growth in Development and Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Research Scholar – Autoimmunity (University of California, Davis)

Postdoctoral Fellowship – Gene Therapy of the Human Skin (The University of British Columbia)

Postdoctoral Position – Immune Mechanisms of Allergic Diseases (Boston Children’s Hospital)

Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California)

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