Dermal Cell News Volume 5.33 | Sep 30 2019

TOP STORY

IFN-γ Enhances Cell-Mediated Cytotoxicity against Keratinocytes via JAK2/STAT1 in Lichen Planus

The type II interferon (IFN), IFN-γ, was demonstrated to prime keratinocytes and increased their susceptibility to CD8⁺ T cell-mediated cytotoxic responses through MHC class I induction in a coculture model. [Sci Transl Med] Abstract

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

An RNAi Screen Unravels the Complexities of Rho GTPase Networks in Skin Morphogenesis

Scientists unveiled hitherto unrecognized roles for Rho-mediated cytoskeletal remodeling events that impact hair follicle specification, differentiation, downgrowth and planar cell polarity. [eLife] Full Article

Particulate Matter-Induced Senescence of Skin Keratinocytes Involves Oxidative Stress-Dependent Epigenetic Modifications

Researchers investigated how epigenetic regulatory mechanisms participated in cellular senescence induced by particulate matter with a diameter <2.5 in human keratinocytes and mouse skin tissues. [Exp Mol Med] Full Article

BMP2-Mediated PTEN Enhancement Promotes Differentiation of Hair Follicle Stem Cells by Inducing Autophagy

Hair follicle stem cells overexpressing BMP2 exhibited elevated expression of epidermal differentiation marker, adipogenic markers and autophagy-related factors but inhibited expression of keratinocyte-specific marker and proliferation-related markers. [Exp Cell Res] Abstract

Cytoskeleton Protein 4.1R Suppresses Murine Keratinocyte Cell Hyperproliferation via Activating the Akt/ERK Pathway in an EGFR-Dependent Manner

The authors report that 4.1R, a member of the membrane-cytoskeleton linker FERM family proteins plays critical roles in epidermal growth factor receptor (EGFR) activation and signaling in keratinocytes. They demonstrated that knockout of 4.1R augmented the excessive proliferation potential of keratinocytes by immunohistochemical analysis using murine skin samples. [Exp Cell Res] Abstract

Nitidine Chloride Induces S Phase Cell Cycle Arrest and Mitochondria-Dependent Apoptosis in HaCaT Cells and Ameliorates Skin Lesions in Psoriasis-Like Mouse Models

Scientists screened over 600 natural compounds to identify viability inhibitors of human HaCaT keratinocytes cultured in vitro. [Eur J Pharmacol] Abstract

SKIN CANCERS & DISORDERS

Keratinocyte Cadherin Desmoglein 1 Controls Melanocyte Behavior through Paracrine Signaling

Investigators uncovered a surprising new function for the keratinocyte‐specific cell‐cell adhesion molecule desmoglein 1 in regulating keratinocyte:melanocyte paracrine signaling to promote the tanning response in the absence of ultraviolet exposure. [Pigment Cell Melanoma Res] Abstract

Diazepam Enhances Melanogenesis, Melanocyte Dendricity and Melanosome Transport via the PBR/cAMP/PKA Pathway

Scientists determined the effects of diazepam on melanogenesis, cellular phenotypic alterations, the location of melanosomes and the expression of relevant proteins in melanocytes using Masson-Fontana ammoniacal silver staining, scanning electron microscopy, immunocytochemistry and western blot analysis. [Int J Biochem Cell Biol] Abstract

In Vitro Selective Cytotoxicity of the Dietary Chalcone Cardamonin (CD) on Melanoma Compared to Healthy Cells Is Mediated by Apoptosis

The effect of the dietary chalcone cardamonin, inter alia found in Alpinia species, was tested using human malignant melanoma cells. [PLoS One] Full Article

Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cancer Stem Cell News.

The Landmark Series: Non-Melanoma Skin Cancers

The authors focus on the landmark clinical trials that led to FDA approval of Vismodegib for advanced basal cell carcinoma and pembrolizumab for advanced Merkel cell carcinoma. [Ann Surg Oncol] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

Pfizer Announces Positive Top-Line Results from Second Pivotal Phase III Study of Investigational Oral JAK1 Candidate, Abrocitinib, in Patients Aged 12 and Older with Moderate to Severe Atopic Dermatitis

Pfizer Inc. announced positive top-line results from a second Phase III pivotal study evaluating the efficacy and safety of its investigational oral Janus kinase 1 (JAK1) inhibitor, abrocitinib, in patients aged 12 and older with moderate to severe atopic dermatitis. [Pfizer Inc.] Press Release

Incyte Announces First Patient Treated in Phase III Clinical Trial Program Evaluating Ruxolitinib Cream in Patients with Vitiligo

Incyte announced that the first patient has been treated in the Phase III TRuE-V clinical trial program evaluating the safety and efficacy of ruxolitinib cream as a monotherapy for adolescent and adult patients with vitiligo. [Incyte Corporation] Press Release

Abeona Therapeutics Provides Regulatory Update Ahead of Pivotal Phase III Clinical Trial for EB-101 in Recessive Dystrophic Epidermolysis Bullosa

Abeona Therapeutics Inc. announced that it has recently received a clinical hold letter from the FDA clarifying that the FDA will not provide approval for the company to begin its planned Phase III clinical trial for EB-101 until it submits to the FDA additional data points on transport stability of EB-101 to clinical sites. [Abeona Therapeutics Inc.] Press Release

Bristol-Myers Squibb Receives Positive CHMP Opinion Recommending Approval of Opdivo (Nivolumab) Four-Week Dosing Schedule for the Adjuvant Treatment of Adult Patients with Melanoma with Involvement of Lymph Nodes or Metastatic Disease who Have Undergone Complete Resection

Bristol-Myers Squibb Company announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has recommended approval of Opdivo flat dosing schedule of 240 mg infused over 30 minutes every two weeks or 480 mg infused over 60 minutes every four weeks for the adjuvant treatment of adult patients with melanoma with involvement of lymph nodes or metastatic disease who have undergone complete resection. [Bristol-Myers Squibb Company] Press Release

NIH Reveals Its Formula for Tracking Foreign Influences

The US National Institutes of Health (NIH) thinks it may have figured out how China’s foreign talents recruitment program is undermining its system for making awards and ensuring ethical behavior by its grantees. [ScienceInsider] Editorial

How Us Sanctions Are Crippling Science in Iran

After almost a year of sanctions put in place by US President Donald Trump, Iran is experiencing economic recession, a depreciating currency and high inflation. All of this is stretching budgets for equipment, supplies and travel, endangering research projects and sapping morale, say researchers. [Nature News] Editorial

NEW Stromal Cells in Immunity and Disease
February 19-23, 2020
Victoria, British Columbia, Canada

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Studies – Bioinformatics to Understand T Cell Biology (Karolinska Institutet)

Scientific Officer – Human Skin and Lung Toxicology (Federal Institute for Risk Assessment)

Postdoctoral Fellowship – Dermatology (Brigham and Women’s Hospital)

Postdoctoral Fellowship – Wound Healing and Tissue Regeneration (Memorial Sloan Kettering Cancer Center)

Faculty Positions – Cutaneous Oncology and Skin Cancer Research (Columbia University Medical Center)

Postdoctoral Researcher – Cancer Research (Champalimaud Foundation)

Postdoctoral Position – Cancer Immunology (Northwestern University Feinberg School of Medicine)

Faculty Position – Cancer Biology (Children’s Research Institute at UT Southwestern)

Faculty Position – Cancer Biology (Emory University)

Postdoctoral Research Fellow – Epithelial Growth in Development and Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Research Scholar – Autoimmunity (University of California, Davis)

Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Dermal Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.