Dermal Cell News Volume 5.34 | Oct 7 2019

TOP STORY

Novel Cell States in Melanoma Progression and Residual Disease

Using zebrafish, researchers established that the MITF-low gene expression state was a “driver cell state” and that it was highly similar to human MITF-low melanomas. [Press release from The University of Edinburgh discussing online prepublication in Cancer Research] Press Release | Abstract

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

The Desmosomal Cadherin Desmoglein-3 Acts as a Keratinocyte Anti-Stress Protein via Suppression of p53

The authors showed that expression of desmoglein-3 impacts on the expression and function of p53, a key transcription factor governing the responses to cellular stress. [Cell Death Dis] Full Article

Characterization and Establishment of an Immortalized Rabbit Melanocyte Cell Line Using the SV40 Large T Antigen

Investigators transformed lentivirus-mediated simian virus 40 (SV40) Large T into primary rabbit melanocytes to establish an immortalized cell line. [Int J Mol Sci] Full Article

Hsp90α Promotes the Migration of iPSC-Derived Keratinocyte to Accelerate Deep Second-Degree Burn Wound Healing in Mice

Researchers investigated the effects of Hsp90α on transplanted induced pluripotent stem cell (iPSC)-derived keratinocyte in a skin model of deep second degree burns. [Biochem Biophys Res Commun] Abstract

SKIN CANCERS & DISORDERS

ADP Secreted by Dying Melanoma Cells Mediates Chemotaxis and Chemokine Secretion of Macrophages via the Purinergic Receptor P2Y12

P2Y12⁺ macrophages migrated towards the ADP-rich culture medium of puromycin-treated dying B16F1 melanoma cells. [Cell Death Dis] Full Article

The Transmembrane Protein LRIG2 Increases Tumor Progression in Skin Carcinogenesis

The authors investigated leucine‐rich repeats and immunoglobulin‐like domains 2 (LRIG2), a transmembrane protein involved in feedback loop regulation of the ERBB receptor family during non‐melanoma skin cancer. [Mol Oncol] Abstract

Loss of CYLD Accelerates Melanoma Development and Progression in the Tg(Grm1) Melanoma Mouse Model

Investigators demonstrated that cylindromatosis (Cyld)-deficiency led to earlier melanoma onset and accelerated tumor growth and metastasis in the GRM1 melanoma mouse model. [Oncogenesis] Full Article

Targeting CDC7 Sensitizes Resistance Melanoma Cells to BRAF^V600E-Specific Inhibitor by Blocking the CDC7/MCM2-7 Pathway

Scientists aimed to elucidate the biological role of CDC7 in promoting Vemurafenib resistance and the anticipated benefits of dual targeting of BRAF^V600E and CDC7 in melanoma cells. [Sci Rep] Full Article

Hair Follicle Differentiation Specific Keratin Expression in Human Basal Cell Carcinoma

Basal cell carcinoma, squamous cell carcinoma, and normal skin tissues were analyzed using a Illumina HumanHT‐12 v4 Expression Microarray chip. The expression of individual keratins, regulatory pathways and proliferative states were analyzed using RT‐PCR and immunofluorescence microscopy. [Clin Exp Dermatol] Abstract

Effect of Mechanical Compression on Invasion Process of Malignant Melanoma Using In Vitro Three-Dimensional Cell Culture Device

Investigators developed an in vitro three-dimensional cell culture device using microporous membrane in order to evaluate the effects of mechanical compression on the invasion process of malignant melanoma. [Micromachines] Abstract | Download Full Article

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STAT3 and STAT5 Targeting for Simultaneous Management of Melanoma and Autoimmune Diseases

The authors review the recent advances of STAT3 and STAT5 targeting in melanoma, explore which autoimmune diseases are causatively linked to STAT3 and/or STAT5 signaling, and propose that these patients may particularly benefit from treatment with STAT3/STAT5 inhibitors. [Cancers] Full Article

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

Keck School of Medicine of USC and Science 37^® Collaborate on Largest Ever NIH-Funded, Telemedicine-Based Dermatology Study

Science 37 and the Keck School of Medicine of the University of Southern California (USC) announced a partnership agreement that will support the execution of a $3.4 million study funded by the National Institutes of Health (NIH)—the largest telemedicine-based dermatology study ever funded by the organization. [Science 37, Inc.] Press Release

AnaptysBio Reports Positive Topline Data from Interim Analysis of GALLOP Phase II Clinical Trial of ANB019 Monotherapy in Moderate-to-Severe Generalized Pustular Psoriasis

AnaptysBio, Inc. announced positive topline data from an interim analysis of its Phase II clinical trial of ANB019 in moderate-to-severe generalized pustular psoriasis patients, also known as the GALLOP trial. [AnaptysBio, Inc.] Press Release

Nektar Therapeutics Announces Initiation of Two Clinical Studies of Novel T Regulatory Cell Stimulator NKTR-358 (LY3471851) in Patients with Psoriasis and Atopic Dermatitis

Nektar Therapeutics announced the initiation of two Phase Ib studies of NKTR-358, a novel T regulatory cell stimulator, one in patients with psoriasis and one in patients with atopic dermatitis. [Nektar Therapeutics] Press Release

Janssen Submits Application to US FDA Seeking Approval of STELARA^® (Ustekinumab) for the Treatment of Pediatric Patients with Moderate to Severe Plaque Psoriasis

The Janssen Pharmaceutical Companies of Johnson & Johnson announced the submission of a supplemental Biologics License Application to the FDA seeking expanded approval of STELARA^® to treat pediatric patients with moderate to severe plaque psoriasis. [Janssen Global Services, LLC] Press Release

Yale Scientists Win NIH Awards for Pioneering Work

The Yale School of Medicine’s Valentina Greco and Marina R. Picciotto are among the 11 recipients of the National Institutes of Health’s (NIH) Pioneer Award, which recognizes scientists who have a history of creative research and who show promise in originating “pioneering approaches to major challenges.” [Yale University] Press Release

Biologists Who Decoded How Cells Sense Oxygen Win Medicine Nobel

A trio of researchers has won the 2019 Nobel Prize in Physiology or Medicine for describing how cells sense and respond to changing oxygen levels by switching genes on and off — a discovery that has been key in understanding human diseases such as cancer and anemia. [Nature News] Editorial

Split Decisions: How Brexit Has Taken a Toll on Five Researchers

On 23 June 2016, 34 million U.K. citizens took to the polls to vote on a simple, fateful question: Should the United Kingdom remain a part of the European Union, or should it leave? Nearly 52%—a majority of 1.3 million—wanted out, and conservative politicians vowed to carry out the people’s wishes. [ScienceInsider] Editorial

NEW ISSCR 2020 Stem Cells and Regenerative Medicine
March 13-15, 2020
Shanghai, China

Visit our events page to see a complete list of events in the community.

NEW Assistant Professor – Biochemistry (University of Washington)

Postdoctoral Studies – Bioinformatics to Understand T Cell Biology (Karolinska Institutet)

Scientific Officer – Human Skin and Lung Toxicology (Federal Institute for Risk Assessment)

Postdoctoral Fellowship – Dermatology (Brigham and Women’s Hospital)

Postdoctoral Fellowship – Wound Healing and Tissue Regeneration (Memorial Sloan Kettering Cancer Center)

Faculty Positions – Cutaneous Oncology and Skin Cancer Research (Columbia University Medical Center)

Postdoctoral Researcher – Cancer Research (Champalimaud Foundation)

Postdoctoral Position – Cancer Immunology (Northwestern University Feinberg School of Medicine)

Faculty Position – Cancer Biology (Children’s Research Institute at UT Southwestern)

Faculty Position – Cancer Biology (Emory University)

Postdoctoral Research Fellow – Epithelial Growth in Development and Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Research Scholar – Autoimmunity (University of California, Davis)

Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California)

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