Dermal Cell News 5.35 October 21, 2019 | |
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TOP STORYKeratinocyte-Derived IκBζ Drives Psoriasis and Associated Systemic Inflammation Scientists found that IκBζ expression in keratinocytes triggered not only skin lesions, but also systemic inflammation in mouse psoriasis models. Specific depletion of IκBζ in keratinocytes was sufficient to suppress the induction of imiquimod- or IL-36-mediated psoriasis. [J Clin Invest] Abstract | Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONIRF2 Is a Master Regulator of Human Keratinocyte Stem Cell Fate Researchers investigated whether transcriptional circuitry also governed phenotypic changes within a given cell type by comparing human primary keratinocytes with intrinsically high versus low stem cell potential. Using integrated chromatin and transcriptional profiling, they implicated interferon regulatory factor 2 (IRF2) as antagonistic to stemness and showed that it bound and regulated active cis-regulatory elements at interferon response and antigen presentation genes. [Nat Commun] Full Article The authors showed that stable and transient downregulation of the transcription factor Krüppel-like factor 4 (KLF4) in keratinocyte precursors from adult skin, using anti-KLF4 RNA interference or kenpaullone, promoted keratinocyte immaturity and keratinocyte self-renewal in vitro, and enhanced the capacity for epidermal regeneration in mice. [Nat Biomed Eng] Abstract The effects of 17-oxo-docosahexaenoic acid (17-oxo-DHA) on Nrf2-mediated expression of cytoprotective enzymes were examined in mouse skin in vivo and cultured murine epidermal JB6 cells. Topical application of 17-oxo-DHA markedly elevated the nuclear localization of Nrf2 and expression of heme oxygenase and NAD(P)H:quinone oxidoreductase in hairless mouse skin. [Arch Biochem Biophys] Abstract Bioassay-guided fractionation of an extract of leaves and twigs of E. umbellata led to the isolation of a serotonin derivative, N-[2-(5-hydroxyl-1H-indol-3-yl)ethyl]-butanamide, along with six flavonoid glycosides. Their structures were elucidated using 1D/2D nuclear magnetic resonance spectroscopy and mass spectrometry. Six compounds were evaluated for their proliferative effects on HaCaT keratinocytes; five compounds promoted keratinocyte proliferation dose dependently. [Fitoterapia] Abstract | Graphical Abstract SKIN CANCERS & DISORDERSGenetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses Investigators identified six melanoma lines harboring BRAF fusions representative of the clinical cases reported in the literature. Their unexpected heterogeneous responses to RAF and MEK inhibitors could be categorized upon specific features of the fusion kinases. [Cell Rep] Full Article | Graphical Abstract Inhibition of p38/MK2 Signaling Prevents Vascular Invasion of Melanoma Signaling pathways involved in this switch were analyzed by gene expression profiling of a cohort of 22 patient-derived melanoma cell lines. E-cadherin/CDH1 negativity was identified as a surrogate marker for the invasive phenotype. [J Invest Dermatol] Abstract | Graphical Abstract Investigators analyzed the expression and regulatory mechanisms of glycosyltransferase genes responsible for ganglioside synthesis in normal melanocytes. They reported previously that culture supernatants of UVB-irradiated keratinocytes induced upregulation of ganglioside GD3 synthase gene in melanocytes, and mainly TNFα was responsible for it. [Sci Rep] Full Article Researchers focused on the role of a recently-found dermis zinc transporter, ZIP13, in fibrosarcoma progression. They generated two transformed cell lines from wild-type and ZIP13-KO mice-derived dermal fibroblasts by stably expressing the simian virus 40-T antigen. The ZIP13−/− cell line exhibited an impairment in autophagy, followed by hypersensitivity to nutrient deficiency. [Sci Rep] Full Article The authors showed a simply and highly reproducible reverse-phase high-performance liquid chromatographic method for the determination of ortho-phthalaldehyde derivatives of polyamines: putrescine, cadaverine, spermidine and spermine. [Amino Acids] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cancer Stem Cell News. | |
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REVIEWSA Review of Accelerated Wound Healing Approaches: Biomaterial-Assisted Tissue Remodeling The authors discuss tissue remodeling phenomena, wound healing mechanisms, and their related factors. In addition, they review different methods for induction and acceleration of healing via cell therapy, bioactive therapeutic delivery, and/or biomaterial-based approaches. [J Mater Sci] Abstract Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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INDUSTRY NEWSReplimune Provides Update on RP1 Clinical Development Program in Cutaneous Squamous Cell Carcinoma Replimune Group Inc. announced that the first patient has been enrolled in its registration-directed, randomized, controlled Phase II clinical trial of RP1 in combination with Regeneron and Sanofi’s Libtayo® (cemiplimab-rwlc) compared to Libtayo alone in patients with cutaneous squamous cell carcinoma. [Replimune Group, Inc.] Press Release Foamix Pharmaceuticals Limited announced that the FDA has accepted for review the New Drug Application for FMX103 (minocycline topical foam 1.5%) topical foam. Foamix is seeking approval of FMX103 for the treatment of moderate-to-severe papulopustular rosacea in adults. The FDA has set June 2nd, 2020 as the Prescription Drug User Fee Act action date. [Foamix Pharmaceuticals Limited] Press Release | |
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POLICY NEWS$3 Billion Ballot Proposition Will Decide Fate of Texas Cancer Research Funding Agency On 5 November, Texas residents will decide whether to sustain CPRIT, the second largest public source of cancer funding in the United States after the federal government. At stake is its generous support for 123 tenure-track faculty like Cole, who investigates cancer and DNA repair. [ScienceMagazine] Editorial Indian Government Tightens Rules on Academic Collaboration with China India is tightening the rules for academic collaborations with its neighbor and main rival, China. Under a new policy, universities and research institutes must seek permission from the ministries of Home Affairs and External Affairs before signing a collaboration agreement or memorandum of understanding with a Chinese institution. [ScienceMagazine] Editorial
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EVENTSNEW Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Meeting 2020 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Coordinator – Dermatology and Venereology (Karolinska Institutet) NEW Medical Science Liaison – Dermatology (Eli Lilly and Company) Assistant Professor – Biochemistry (University of Washington) Postdoctoral Studies – Bioinformatics to Understand T Cell Biology (Karolinska Institutet) Postdoctoral Fellowship – Dermatology (Brigham and Women’s Hospital) Faculty Positions – Cutaneous Oncology and Skin Cancer Research (Columbia University Medical Center) Postdoctoral Researcher – Cancer Research (Champalimaud Foundation) Postdoctoral Position – Cancer Immunology (Northwestern University Feinberg School of Medicine) Faculty Position – Cancer Biology (Children’s Research Institute at UT Southwestern) Faculty Position – Cancer Biology (Emory University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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