Dermal Cell News Volume 6.02 | Jan 20 2020

TOP STORY

Tertiary Lymphoid Structures Improve Immunotherapy and Survival in Melanoma

Scientists used clinical samples of metastatic melanomas to investigate the role of B cells in antitumor responses, and found that the co-occurrence of tumor-associated CD8⁺ T cells and CD20⁺ B cells was associated with improved survival, independently of other clinical variables. [Nature] Abstract | Press Release

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

Chemically Defined and Xenogeneic-Free Culture Method for Human Epidermal Keratinocytes on Laminin-Based Matrices

Investigators describe how to implement a defined, xeno-free culture system that supports long-term ex vivo expansion of functional human epidermal keratinocytes. [Nat Protoc] Full Article

Improvement of Epidermal Covering on AEC Patients with Severe Skin Erosions by PRIMA-1MET/APR-246

Researchers established primary epidermal culture from two AEC children suffering from persistent skin erosions at age of 9 and 15, respectively. They found that primary keratinocytes isolated from these AEC patients underwent altered epidermal differentiation that was rescued by PRIMA-1^MET treatment. [Cell Death Dis] Full Article

Cadherin-11 Binds to PDGFRβ and Enhances Cell Proliferation and Tissue Regeneration via the PDGFR-AKT Signaling Axis

The authors provided evidence that cadherin-11 bound to and promoted cell proliferation both in vitro and in vivo in synergy with the platelet-derived growth factor receptor beta (PDGFRβ). [FASEB J] Full Article

SKIN CANCERS & DISORDERS

Inflammation-Induced IgE Promotes Epithelial Hyperplasia and Tumor Growth

Skin inflammation enhanced levels of IgE antibodies that had natural specificities and a repertoire, VDJ rearrangements and CDRH3 characteristics similar to those of IgE antibodies in healthy tissue. [eLife] Full Article

A Rose Bengal-Amphiphilic Peptide Conjugate for Enhanced Photodynamic Therapy of Malignant Melanoma

Scientists covalently attached Rose Bengal to the amphipathic peptide C(KLAKLAK)2 and determined the effectiveness of the resulting RB-C(KLAKLAK)2 conjugate as a photodynamic therapy sensitizer. [J Med Chem] Abstract | Graphical Abstract

Targeting BRD/BET Proteins Inhibits Adaptive Kinome Upregulation and Enhances the Effects of BRAF/MEK Inhibitors in Melanoma

Melanoma growth was evaluated in vitro by colony assay and EdU staining, as well as in skin reconstructs, xenografts and PDX models following BRAF inhibitors, MEK inhibitors and/or PLX51107 treatment. [Br J Cancer] Abstract

Biomimetic Tissue Models Reveal the Role of Hyaluronan in Melanoma Proliferation and Invasion

Investigators generated in vivo mouse models with low and high expression of Has2 and used the models for studying melanoma proliferation of the B78D14 melanoma cell line. [Biomater Sci] Full Article

Individual and Combined Effects of the Infrared, Visible, and Ultraviolet Light Components of Solar Radiation on Damage Biomarkers in Human Skin Cells

Researchers compared the effects of physiologically relevant doses of complete solar-simulated light and its individual components on matched primary dermal fibroblasts and epidermal keratinocytes from human donors on three biomarkers of cellular damage. [FASEB J] Abstract

Mesenchymal Stem Cells Promote Human Melanocytes Proliferation and Resistance to Apoptosis through PTEN Pathway in Vitiligo

Scientists cocultured primary melanocytes with mesenchymal stem cells (MSCs) in a Transwell system to explore how MSCs inhibit the PTEN/PI3K/AKT pathway in melanocytes. [Stem Cell Res Ther] Full Article

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Significance of 5-S-Cysteinyldopa as a Marker for Melanoma

The authors summarize the usefulness of 5-S-cysteinyldopa (5SCD), the most widely used and well-known melanoma marker in the serum and urine, compares 5SCD and other useful markers, and finally its application to other fields. [Int J Mol Sci] Full Article | Graphical Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

Checkpoint Therapeutics Announces Confirmation of Registration Path for Cosibelimab in Metastatic Cutaneous Squamous Cell Carcinoma

Checkpoint Therapeutics, Inc. announced that feedback from the US FDA has confirmed the company’s plan to submit cosibelimab for full approval as a treatment for patients with metastatic cutaneous squamous cell carcinoma based on efficacy and safety data from the ongoing open-label, multicenter, Phase I clinical trial, Study CK-301-101. [Checkpoint Therapeutics, Inc.] Press Release

Iovance Biotherapeutics Completes Patient Dosing in Registration-Enabling Cohort 4 of the C-144-01 Melanoma Study with Lifileucel

Iovance Biotherapeutics, Inc. announced that the company has completed dosing the last patient in the registration-enabling Cohort 4 of the C-144-01 study of lifileucel in the treatment of patients with advanced melanoma. [Iovance Biotherapeutics, Inc.] Press Release

Campus Attacks by Nationalists and Police Alarm India’s Scientific Community

Early in the evening on 5 January, more than 70 masked hoodlums armed with iron rods, stones, and sticks entered the campus of Jawaharlal Nehru University. They set upon teachers and students who were holding a peaceful political gathering, and marched into student hostels, terrorizing and injuring dozens. [ScienceInsider] Editorial

Senate Bill Would Boost Spending on Trump Administration’s Research Priorities

A bipartisan group of senators asked the Trump administration to pump up funding for a handful of technologies they believe will drive future US economic growth. And the top White House technology officer thinks it’s a great idea. [ScienceInsider] Editorial

NEW 2^nd Epigenetics Conference
February 28-March 2, 2020
Nassau, Bahamas

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Tissue Repair and Inflammation (Memorial Sloan Kettering Cancer Center)

NEW Postdoctoral Fellow – Cancer Research (University of California San Diego Moores Cancer)

Research Fellow – Inherited Skin Conditions (University College London)

Postdoctoral Fellowship – DNA Repair in Skin Melanoma Prevention (University of Southern California)

Laboratory Research Scientist – Advanced Sequencing Facility in Melanoma (The Francis Crick Institute)

Postdoctoral Position – Microbiota and Autoimmunity (The University of Arizona)

Chief Position – Allergy, Immunology, Rheumatology and Dermatology (Harvard Medical School)

Senior Associate Researcher – Inflammatory Skin Diseases (Icahn School of Medicine at Mount Sinai)

Postdoctoral Position – RNA Binding Activity of Glycolytic Enzymes in Melanoma (Institut Curie)

Postdoctoral Research Fellow – DNA Damage Signaling in Cancer Biology (Memorial Sloan Kettering Cancer Center)

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