Dermal Cell News Volume 6.07 | Mar 2 2020

TOP STORY

A Molecular Atlas of Skin Cells

Our skin protects us from physical injury, radiation and microbes, and at the same time produces hair and facilitates perspiration. Details of how skin cells manage such disparate tasks have so far remained elusive. Now, researchers have systematically mapped skin cells and their genetic programs, creating a detailed molecular atlas of the skin in its complexity. [Press release from Karolinska Institutet discussing online prepublication in Cell Stem Cell] Press Release | Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

SMURF2 Prevents Detrimental Changes to Chromatin, Protecting Human Dermal Fibroblasts from Chromosomal Instability and Tumorigenesis

Investigators showed that SMURF2 was essential to protect human dermal fibroblasts (HDFs) from malignant transformation, and its depletion converted HDFs into a tumorigenic entity. [Oncogene] Abstract

A Developed Serum-Free Medium and an Optimized Chemical Cocktail for Direct Conversion of Human Dermal Fibroblasts into Brown Adipocytes

Serum-free brown adipogenic medium with an optimized chemical cocktail consisting of Rosiglitazone, Forskolin, and BMP7 efficiently converted human dermal fibroblasts into chemical compound-induced brown adipocytes (ciBAs) within four weeks. The ciBAs exhibited increased mitochondrial levels, elevated oxygen consumption rate, and a response to β-adrenergic receptor agonists. [Sci Rep] Full Article

The Overexpression of Epidermal Growth Factor (EGF) in HaCaT Cells Promotes the Proliferation, Migration, Invasion and Transdifferentiation to Epidermal Stem Cell Immunophenotyping of Adipose-Derived Stem Cells (ADSCs)

The authors explored the role of EGF in the proliferation, invasion, migration and transdifferentiation into epidermal cell phenotypes of ADSCs. [Int J Stem Cells] Abstract

Quantitative and Qualitative Analysis of Integrin Subtype Expression in Melanocytes and Melanoma Cells

Seven melanoma cell lines as well as normal human melanocytes were investigated in western blots including recombinant integrin subunits for quantification. [J Recept Signal Transduct Res] Abstract

Effects of Denture Adhesives and Mouth Moisturizers to Human Oral Fibroblast and Human Keratinocyte Cells Using Direct and Indirect Cell Culture Systems

Scientists evaluated the effects of commercialized denture adhesives and mouth moisturizers using direct and indirect cell cultures for in vitro examinations with human fibroblast and epithelial cells. [Dent Mater J] Abstract

SKIN CANCERS & DISORDERS

Tracking Extracellular Vesicle Phenotypic Changes Enables Treatment Monitoring in Melanoma

Investigators demonstrated the feasibility of monitoring patient treatment responses based on the plasma extracellular vesicle (EV) phenotypic evolution using a multiplex EV phenotype analyzer chip (EPAC). EPAC incorporated the nanomixing-enhanced microchip and the multiplex surface-enhanced Raman scattering nanotag system for direct EV phenotyping without EV enrichment. [Sci Adv] Full Article

β3-Adrenoreceptor Blockade Induces Stem Cells Differentiation in Melanoma Microenvironment

Researchers showed that in B16 melanoma-bearing mice, the pharmacological β2-adrenoreceptor blockade was able to reduce the expression of cancer stem cell markers, and to induce a differentiated phenotype of hematopoietic subpopulations in tumor microenvironment. [Int J Mol Sci] Full Article

Combination of Gas Plasma and Radiotherapy Has Immunostimulatory Potential and Additive Toxicity in Murine Melanoma Cells In Vitro

To test whether plasma treatment would enhance the toxicity of an established antitumor therapy, ionizing radiation, investigators combined both physical treatment modalities targeting B16F10 murine melanoma cell in vitro. [Int J Mol Sci] Full Article

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Current Insight into the Roles of MicroRNA in Vitiligo

Researchers summarize miRNA expression profiles in different tissues of vitiligo patients and the mechanisms by which key miRNAs mediate vitiligo development. [Mol Biol Rep] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

MTF Biologics Awards $1.8 Million in 2019 Extramural Research Grants

MTF Biologics has awarded over $1.8 million in funding to 12 researchers across the nation through its 2019 Extramural Research Grants Program. [MTF Biologics] Press Release

Athenex’s Partner Almirall Announces EMA Acceptance for Filing of Marketing Authorization Application (MAA) for Tirbanibulin Ointment in Actinic Keratosis

Athenex, Inc. provided an update that its partner, Almirall, announced that the European Medicines Agency (EMA) has accepted the filing of the Marketing Authorization Application (MAA) for tirbanibulin ointment for the treatment of actinic keratosis. [Athenex, Inc.] Press Release

China Bans Cash Rewards for Publishing Papers

Chinese institutions have been told to stop paying researchers bonuses for publishing in journals, as part of a new national policy to cut perverse incentives that encourage scientists to publish lots of papers rather than focus on high-impact work. [Nature News] Editorial

UC Santa Cruz Fires Graduate Students Taking Part in Strike

The University of California, Santa Cruz, fired 54 graduate student employees from their teaching positions on February 28, in the latest escalation of a months-long dispute over student pay, the Santa Cruz Sentinel reports. [The Scientist] Editorial

NEW Tissue Engineering and Regenerative Medicine Asia-Pacific Conference 2020
September 21-24, 2020
Kuala Lumpur, Malaysia

Visit our events page to see a complete list of events in the community.

NEW Assistant Professor – Dermatology (Massachusetts General Hospital)

Postdoctoral Position – Bioinformatics or Statistical Genetics (University of California, San Francisco)

Faculty Positions – Dermatology (Columbia University)

Senior Research Scientist – Sarcoma (Memorial Sloan Kettering Cancer Center)

Postdoctoral Position – Cancer Biology (Kentsis Research Group)

Researcher – Dermatopathology (Weill Cornell Medical College)

Postdoctoral Fellow – Cancer Pathogenesis (University of Cincinnati)

Postdoctoral Position – Tissue Repair and Inflammation (Memorial Sloan Kettering Cancer Center)

Postdoctoral Fellow – Cancer Research (University of California, San Diego)

Postdoctoral Fellowship – DNA Repair in Skin Melanoma Prevention (University of Southern California)

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