Dermal Cell News 6.09 March 16, 2020 | |
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TOP STORYResearchers showed that in primary normal human dermal fibroblast cells, merkel cell polyomavirus DNA replication, but not T antigen expression alone, induced ataxia telangiectasia mutated kinase-dependent Kap1 S824 phosphorylation, a mechanism that typically facilitates repair of double-strand breaks in heterochromatin by arresting the cells in G2. [mBio] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONBovine Colostrum Induces the Differentiation of Human Primary Keratinocytes Using cellular and molecular approaches, scientists showed that colostrum favored a cell cycle withdrawal by increasing the expression of p21/WAF1 and p27/KIP1. It also promoted the transition of keratinocytes from a proliferating to a differentiating state, as assessed by a decrease in keratin 5 and an increase in keratin 16. [FASEB J] Full Article Bromodomain and Extra-Terminal Domain (BET) Proteins Regulate Melanocyte Differentiation Investigators showed that chemical inhibition of BET proteins prevented differentiation of unpigmented melanoblasts into pigmented melanocytes and resulted in de-pigmentation of differentiated melanocytes. [Epigenetics Chromatin] Full Article Researchers showed for the first time that phenol red and serum lipids suppressed expression of differentiation-specific keratins K1, K10 and K2 in normal human epidermal keratinocytes and two important cell lines, HaCaT and N/TERT-1. [Sci Rep] Full Article Scientists found that in epidermal keratinocytes soy phosphatidylglycerol inhibited TLR2 and TLR4 activation and inflammatory mediator expression in response to a synthetic triacylated lipopeptide and lipopolysaccharide, respectively, as well as an endogenous danger-associated molecular pattern. [Mol Pharmacol] Abstract The authors showed that α-parvin (α-pv), a focal adhesion protein that couples integrins to actin cytoskeleton, was indispensable for epidermal morphogenesis and hair follicle development. Inactivation of the murine α-pv gene in basal keratinocytes resulted in keratinocyte-basement membrane detachment, epidermal thickening, ectopic keratinocyte proliferation and altered actin cytoskeleton polarization. [PLoS One] Full Article SKIN CANCERS & DISORDERSResearchers evaluated whole-genome mRNA expression profiling associated with different miR-205 expression levels in melanoma cells. [Sci Rep] Full Article αvβ3 Integrin Expression Increases Elasticity in Human Melanoma Cells αvβ3 integrin expression in human melanoma cells increased cell stiffness in both adherent and non-adherent conditions; replacing αvβ3 with αIIbβ3 integrin in melanoma cells, cell stiffness was increased under adherent, while decreased under non-adherent conditions; αvβ3 integrin cell stiffening was also maintained when cells adhered to fibronectin, but this phenomenon did not strongly depend on the fibronectin concentration. [Biochem Biophys Res Commun] Abstract Confocal imaging and flow cytometry assay showed that X polymers could target both T cells and B16 cells in vitro. The authors also showed that X polymers could inhibit mouse melanoma B16 cell growth both in vitro and in vivo. [Mol Ther Oncolytics] Abstract | Full Article Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cancer Stem Cell News. | |
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REVIEWSKeratinocyte: A Trigger or an Executor of Psoriasis? The authors focus on the recent advances in the identification of keratinocytes as a trigger of psoriasis, summarize on the role of keratinocytes in a self‐perpetuating loop to maintain inflammation in psoriasis, and then discuss the possible roles of keratinocytes in the relapse of psoriasis. [J Leukoc Biol] Abstract Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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INDUSTRY NEWSEli Lilly and Company and Incyte Corporation announced that the FDA has granted Breakthrough Therapy designation to baricitinib for the treatment of alopecia areata, an autoimmune disorder that can cause unpredictable hair loss on the scalp, face and other areas of the body. [Eli Lilly and Company] Press Release Asana BioSciences announced positive topline results from a Phase Ib study evaluating the treatment of pruritus associated with atopic dermatitis for its topical sodium channel blocker, ASN008. The Phase Ib double-blind, vehicle-controlled, dose escalation study randomized 25 adult patients with atopic dermatitis and a pruritus score of ≥7 using the Numerical Rating Scale at baseline. [Asana BioSciences (Business Wire, Inc.)] Press Release | |
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POLICY NEWSUK Government to Boost R&D Spending The British government has announced a 15 percent increase in public funding for research and development as part of its 2020 budget in a move that was generally welcomed by scientists. [The Scientist] Editorial Universities Are Forging Ties with the FBI as US Cracks Down on Foreign Influence US universities are forging closer ties with FBI agents, encouraging scientists to disclose foreign sources of research funding, and tightening restrictions on researchers’ travel. [Nature News] Editorial
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EVENTSNEW International Society for Stem Cell Research (ISSCR) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellowship – Dermatology (Brigham and Women’s Hospital) Research Specialist – Stem Cells for Regenerative Medicine (University of Illinois at Chicago) Assistant Professor – Dermatology (Massachusetts General Hospital) Faculty Positions – Dermatology (Columbia University) Senior Research Scientist – Sarcoma (Memorial Sloan Kettering Cancer Center) Postdoctoral Position – Cancer Biology (Kentsis Research Group) Researcher – Dermatopathology (Weill Cornell Medical College) Postdoctoral Fellow – Cancer Pathogenesis (University of Cincinnati) Postdoctoral Fellow – Cancer Research (University of California, San Diego) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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