Dermal Cell News 6.13 April 13, 2020 | |
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TOP STORYPeriostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch Using pharmacological and genetic approaches, scientists inhibited the function of neuronal integrin αVβ3, which significantly reduced periostin-induced itch in mice. They also established that the JAK/STAT pathway is a key regulator of periostin secretion in keratinocytes. [Cell] Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONDefining the Design Principles of Skin Epidermis Postnatal Growth By combining in vivo clonal lineage tracing, proliferation kinetics, single-cell transcriptomics, and in vitro micro-pattern experiments, researchers resolved the cellular dynamics taking place during postnatal skin epidermis expansion. [Cell] Full Article | Graphical Abstract Autophosphorylation at Serine 166 Regulates RIP Kinase 1-Mediated Cell Death and Inflammation The authors showed that serine 166 (S166) autophosphorylation licensed receptor interacting protein kinase (RIPK1) activity to induce downstream cell death signaling and inflammation, suggesting that S166 phosphorylation could serve as a reliable biomarker for RIPK1 kinase-dependent pathologies. [Nat Commun] Full Article SKIN CANCERS & DISORDERSSuppression of the Solar Ultraviolet-Induced Skin Carcinogenesis by TOPK Inhibitor HI-TOPK-032 Researchers demonstrated that T-LAK cell-originated protein kinase (TOPK) could phosphorylate and activate c-Jun at Ser63 and Ser73 in the process of skin carcinogenesis and HI-TOPK-032 could be used as a potential chemopreventive drug against cutaneous squamous cell carcinoma development. [Oncogene] Abstract Investigators found that TRAF6 was significantly upregulated in CAFs adjacent to melanoma cells. They demonstrated that TRAF6 promoted fibroblast proliferation and migration as well as MMP and α-SMA expression. TRAF6 expression in fibroblasts promoted the malignant phenotype of melanoma cells in vitro and in vivo. [J Invest Dermatol] Abstract Scientists suggested that alteronol induced cyto-protective autophagy in melanoma cells through inhibition of Akt/mTOR pathway, attenuating apoptosis and promoting melanoma cell epithelial-mesenchymal transition (EMT) through TGF-β/Smad3 pathway. [Cell Death Dis] Full Article Researchers found that CBD–IL-12 potently synergized with checkpoint-inhibitor to eradicate large established melanomas, induced antigen-specific immunological memory and controlled tumor growth in a genetically engineered mouse model of melanoma. [Nat Biomed Eng] Abstract The authors identified rare cells in the murine melanoma B16F10, and human A2058 and SK-MEL-28 cell lines that expressed pluripotency markers, including Oct4, Nanog, Sox2 and a marker of melanoma cancer cells. [Exp Cell Res] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cancer Stem Cell News. | |
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REVIEWSLearning from Clinical Trials of Neoadjuvant Checkpoint Blockade Investigators discuss the rationale for neoadjuvant immunotherapy in resectable solid tumors based on preclinical and human translational data, summarize the results of recent clinical trials and ongoing research, and focus on future directions for enhancing reverse translation. [Nat Med] Abstract Hair(y) Matters in Melanoma Biology The authors review how understanding the cellular and molecular mechanisms for generating a putative antimelanoma tissue habitat, namely in the bulge, could help to recreate a similar melanoma-suppressive signaling environment in melanoma high-risk individuals. [Trends Mol Med] Abstract Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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INDUSTRY NEWSArch Therapeutics Receives CE Mark Approval for AC5™ Topical Hemostat in Europe Arch Therapeutics, Inc., announced receipt of the Conformité Européenne (CE) mark for its first-in-class wound care product, AC5TM Topical Hemostat. [Arch Therapeutics, Inc.] Press Release The Gairdner Foundation announced the 2020 Canada Gairdner Award laureates, recognizing some of the world’s most significant biomedical research and discoveries. Dr. Elaine Fuchs used skin to study how the tissues of our body are able to replace dying cells and repair wounds. [Gairdner] Press Release | |
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POLICY NEWSAfter Claims of Sex Bias, Scientific Leader at NIH’s Child Health Institute Withdraws from New Job Constantine Stratakis, the geneticist who directed intramural science at the National Institute of Child Health and Human Development for the past decade, withdrew from a position he was slated to take in June as executive director and chief scientific officer of the Research Institute of the McGill University Health Centre in Montreal, Canada. [ScienceInsider] Editorial President of Europe’s Premier Science Funder Resigns amid Criticism That He Neglected Post The president of Europe’s most prestigious funding agency has resigned suddenly after only three months in the post – prompting fiery accusations from the organization’s governing body that he largely neglected his responsibilities. [Nature News] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Assistant – Life Sciences (University of Texas MD Anderson Cancer Center) Professor – Molecular Physiology (Karolinska Institutet) Postdoctoral Research Associate or Research Associate – DNA Damage (Washington State University) PhD Student Position – Skin and Single-Cell Biology (Karolinska Institutet) Postdoctoral Scholar – Cancer Research (The Ohio State University) Assistant Professor – Dermatology (Massachusetts General Hospital) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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