Dermal Cell News 6.17 May 11, 2020 | |
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TOP STORYI-BET726 Suppresses Human Skin Squamous Cell Carcinoma Cell Growth In Vitro and In Vivo Downregulation of bromodomain-containing protein 4-regulated proteins and inhibition of the sphingosine kinase 1-Akt signaling were detected in I-BET726-treated A431 xenograft tumor tissues. I-BET726 inhibited skin squamous cell carcinoma cell growth in vitro and in vivo. [Cell Death Dis] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONInvestigators knocked down and overexpressed ATG7, the critical gene of autophagy, in normal human epidermal melanocytes. They demonstrated that ATG7-dependent autophagy could affect melanin content of melanocytes by regulating melanogenesis. [Cell Death Discov] Full Article PC4 Serves as a Negative Regulator of Skin Wound Healing in Mice Scientists showed decreased migration rate and proliferation ability in cultured primary fibroblasts from a PC4 knock-in mouse model in vitro. They suggested that PC4 might serve as a negative regulator of skin wound healing in mice. [Int J Burn Trauma] Full Article SKIN CANCERS & DISORDERSResearchers used a disease-focused Capture Hi-C experiment to link psoriasis-associated variants with their target genes in psoriasis-relevant cell lines. They demonstrated how activation of a psoriasis-associated enhancer upregulates the KLF4 gene and its downstream targets. [BMC Biol] Full Article The authors found that IgG and IgA autoantibodies to human serum albumin (HSA) may have diagnosis values for autoimmune bullous skin diseases (AIBD). DNA damage-related signaling proteins might be involved in the pathogenic role of anti-HSA autoantibodies in AIBD. [FASEB J] Full Article Scientists showed that both MAPK and IGF1R pathway inhibition, using the ERK inhibitor SCH772984 and the IGF1R inhibitor BMS-754807, respectively, restored BRAF inhibitor sensitivity in melanoma cells lacking histone acetyltransferase 1. [Oncogenesis] Full Article Elucidating the Anti-Melanoma Effect and Mechanisms of Hispolon The authors investigated the anti-cancer effect of hispolon on melanoma cancer cells. B16BL6 cells were treated with different concentrations of hispolon for 24 hours and the effect on oxidative stress, mitochondrial functions, apoptosis and cell proliferation were studied. [Life Sci] Abstract Scientists investigated the anti-proliferation mediated by apoptosis of Moringa Oleifera leaves (MOE) on human melanoma cell lines. MOE inhibited cell growth of A375 cells and A2058 cells in a dose-dependent manner but had little effect on human normal fibroblasts. [Mol Biol Rep] Abstract Researchers demonstrated that vitiligo skin contained a significant proportion of suprabasal melanocytes, associated with disruption of E-cadherin expression, a major protein involved in melanocyte adhesion. [JCI Insight] Full Article | Graphical Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cancer Stem Cell News. | |
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REVIEWSMetabolic Pathways That Control Skin Homeostasis and Inflammation Investigators provide an updated perspective regarding the potential role of nutrient transporters and metabolic pathways that could be common to immune cells and keratinocytes, to control psoriasis and atopic dermatitis. [Trends Mol Med] Full Article Keratinocytes and melanocytes, two cutaneous cell types located within the epidermis, are the origin of most skin cancers, namely carcinomas and melanomas. The author addresses a specificity of melanomas: the role of photo-oxidative stress. [Photochem Photobiol] Abstract Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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INDUSTRY NEWSTopline data for a pivotal, single-arm, open-label trial for Sanofi and Regeneron’s PD-1 inhibitor Libtayo® in patients with advanced basal cell carcinoma therapy have been announced. [Sanofi] Press Release | |
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POLICY NEWSSecretive Jasons to Offer Advice on How to Reopen Academic Labs Shut by Pandemic A group of prominent academic scientists that has been advising the US government on security matters since the Cold War is conducting a quick-turnaround, pro bono study of a new threat to national security-the impact of COVID-19 on academic research. And this time it’s personal. [ScienceInsider] Editorial How Swamped Preprint Servers Are Blocking Bad Coronavirus Research Repositories are rapidly disseminating crucial pandemic science — and they’re screening more closely to guard against poor-quality work. [Nature News] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Senior Scientist – Inflammation Research (Amgen Inc.) Postdoctoral Fellowship (Benaroya Research Institute) Graduate Position – Molecular Oncology (BC Cancer Research Centre) Medical Oncologist – Cutaneous Malignancies (Rush University Medical Center) Senior Researcher – Oncology Biomarker Development (Genentech) Postdoctoral Researcher (University of Erlangen) Postdoctoral Scholar – Cancer Research (The Ohio State University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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