Dermal Cell News Volume 6.19 | Jun 1 2020

TOP STORY

Common Germline Variants of the Human Apoe Gene Modulate Melanoma Progression and Survival

Scientists reported that, in a reversal of their effect on Alzheimer’s disease, the APOE4 and APOE2 variants conferred favorable and poor outcomes in melanoma, respectively. [Nat Med] Full Article

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

Extracellular Serine Controls Epidermal Stem Cell Fate and Tumor Initiation

Researchers revealed extracellular serine as a critical determinant of epidermal stem cell fate and provided insight into how nutrient availability was integrated with stem cell fate decisions during tumor initiation. [Nat Cell Biol] Abstract

Activin-Mediated Alterations of the Fibroblast Transcriptome and Matrisome Control the Biomechanical Properties of Skin Wounds

The authors provided mechanistic insight into the roles of activin in wound repair and fibrosis and identified the functional consequences of alterations in the wound matrisome at the biomechanical level. [Nat Commun] Full Article

Trace Amines Produced by Skin Bacteria Accelerate Wound Healing in Mice

Scientists showed that trace amines (TA)-producing Staphylococcus epidermidis strains expressing SadA were predominant on human skin and that TA accelerated wound healing. [Commun Biol] Full Article

SKIN CANCERS & DISORDERS

Overcoming Genetically-Based Resistance Mechanisms to PD-1 Blockade

Human melanoma cell lines with JAK1/2 knockout became insensitive to interferon-induced antitumor effects, while B2M knockout were no longer recognized by antigen-specific T cells and hence, resistant to cytotoxicity. [Cancer Discov] Abstract

The Msi1-mTOR Pathway Drives the Pathogenesis of Mammary and Extramammary Paget’s Disease

Investigators identified MSI1 ectopic overexpression in basal epithelial cells of human Paget’s disease (PD) skin, and showed that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological, single-cell and molecular levels. [Cell Res] Abstract

Loss of Spry1 Reduces Growth of BRAF^V600-Mutant Cutaneous Melanoma and Improves Response to Targeted Therapy

Spry1 knockdown in three BRAF^V600-mutant cutaneous melanoma cell lines markedly induced cell cycle arrest and apoptosis, repressed cell proliferation in vitro, and impaired tumor growth in vivo. [Cell Death Dis] Full Article

Genetic Target Modulation Employing CRISPR/Cas9 Identifies Glyoxalase 1 as a Novel Molecular Determinant of Invasion and Metastasis in A375 Human Malignant Melanoma Cells In Vitro and In Vivo

Using A375 human malignant melanoma cells with glyoxalase 1 (GLO1) deletion, engineered using CRISPR/Cas9, the authors reported the identification of GLO1 as a novel molecular determinant of invasion and metastasis in malignant melanoma. [Cancers] Full Article

Pre-mRNA Processing Factor 3 Enhances the Progression of Keratinocyte-Derived Cutaneous Squamous Cell Carcinoma by Regulating the JAK2/STAT3 Pathway

Researchers indicated that pre-mRNA processing factor 3 served as a tumor active factor in cutaneous squamous cell carcinomas by targeting the JAK2/STAT3 pathway. [Sci Rep] Full Article

Pivotal Role of CD103 in the Development of Psoriasiform Dermatitis

Investigators reported that CD103 regulated the development of psoriasiform dermatitis through the control of the function of dermal conventional dendritic cells. Deficiency in CD103 exacerbated psoriasiform dermatitis, accompanied by excessive epidermal hyperplasia and infiltration of inflammatory leukocytes. [Sci Rep] Full Article

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Long Non-Coding RNAs in Cutaneous Biology and Keratinocyte Carcinomas

The authors summarize the current evidence of functionally important long non-coding RNAs in cutaneous biology and in keratinocyte carcinomas. [Cell Mol Life Sci] Full Article

Extracellular Vesicle-Mediated Crosstalk between Melanoma and the Immune System: Impact on Tumor Progression and Therapy Response

Investigators highlight the recent advances in extracellular vesicle-mediated crosstalk between melanoma and immune cells and other important cells of the tumor microenvironment. [J Leukoc Biol] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

Sanofi: FDA Approves Dupixent^® (Dupilumab) as First Biologic Medicine for Children Aged 6 to 11 Years with Moderate-to-Severe Atopic Dermatitis

The US FDA have approved Dupixent^® for children aged 6 to 11 years with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. [Sanofi] Press Release

Achilles Therapeutics Doses First Patient in Phase I/II Study in Recurrent or Metastatic Malignant Melanoma

Achilles Therapeutics have announced that it has dosed the first patient in a Phase I/II study of a clonal neoantigen T cell therapy in patients with recurrent or metastatic malignant melanoma. [Achilles Therapeutics Ltd.] Press Release

Universities Will Never Be the Same after the Coronavirus Crisis

The coronavirus crisis is forcing universities to confront long-standing challenges in higher education, such as skyrocketing tuition costs and perceptions of elitism — and some of the resulting changes could be permanent. [Nature News] Editorial

What the Growing Rift Between the US and WHO Means for COVID-19 and Global Health

Experts in health policy are contending with the real possibility that the United States will pull away from the World Health Organization (WHO), fracturing a relationship that began in the wake of the Second World War. [Nature News] Editorial

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NEW Postdoctoral Fellow – Cancer Research (University of Gothenburg)

NEW Postdoctoral Fellowship – Dermatology (Brigham and Women’s Hospital)

Post-Doctoral Fellow (The Wistar Institute)

Post-Doctoral Associate – Melanoma (The Hormel Institute)

Post-Doctoral Reseach Fellow – Skin Immunology (UC Davis)

Analytical Development Chemist (Dermatology)

Postdoctoral Position – Cutaneous Lymphoma (Research Institute of the McGill University Health Centre)

Senior Scientist – Inflammation Research (Amgen Inc.)

Postdoctoral Fellowship (Benaroya Research Institute)

Postdoctoral Position – Cutaneous T-Cell Lymphoma (Research Institute – McGill University Health Centre)

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