 | | Vol. 6.21 – 15 June, 2020 |
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| Investigators showed that caveolae were asymmetrically distributed in melanocytes and particularly abundant at the melanocyte-keratinocyte interface in epidermis.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
| | Using a Gfra1 (glial-cell-derived neurotrophic factor (GDNF) family receptor alpha 1) knock-in reporter mouse line, GDNF signaling was found to occur within hair bulge stem cells during the initiation of the hair cycle and early stages of hair formation after depilation.
[NPJ Regenerative Medicine] |
| | Scientists found that prolonged expression of transgenic p16INK4a in the mouse epidermis induced hyperplasia and dysplasia, involving high proliferation rates of keratinocytes not expressing the transgene.
[Nature Communications] |
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| Researchers showed that melanocyte-specific expression of human MX2 in a zebrafish model demonstrated accelerated melanoma formation in a BRAFV600E background.
[Nature Communications] |
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| Using a cancer cell model to trigger non-lethal caspase activation, the authors found that melanoma cancer cells undergoing failed apoptosis had a particular transcriptomic signature associated with focal adhesions, transendothelial migration, and modifications of the actin cytoskeleton.
[Cell Reports] |
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| Researchers clarified that virus invasion significantly activated MDA5 and further potentiated the keratinocyte-derived CXCL10 and CXCL16 which are the two vital chemokines for the cutaneous infiltration of CD8+ T cells in vitiligo.
[Cell Death & Disease] |
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| The authors report that over-expressed POU4F1 contributed to the acquired resistance of melanoma cells to Vemurafenib. POU4F1 also promoted the activation of ERK signaling pathway via transcriptional regulation on MEK expression.
[Cell Death & Disease] |
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| Researchers investigated the effects of endothelin-1 (ET-1) receptor antagonist on imiquimod-induced psoriasiform dermatitis in a mouse model and found that ET-1 and endothelin A receptor axis played an important role in the pathogenesis of psoriasis.
[Scientific Reports] |
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| Scientists investigated the antipsoriatic activity of topical administration of resveratrol oligomers and explored the effect of the number of resveratrol subunits on skin absorption to establish the structure-permeation relationship.
[International Journal of Pharmaceutics] |
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| Researchers have established a highly efficient method for precise deletion of critical gene sequences in primary human keratinocytes, based on CRISPR/Cas9-mediated gene editing.
[Molecular Therapy-Methods & Clinical Development] |
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| Scientists showed that IRAK-M, a negative regulator of MyD88 signaling, was deficient or low in melanoma and expression levels correlated with patient survival. Inducing IRAK-M expression using genetic approaches or epigenetic modifiers initiated apoptosis by prompting its interaction with TRAF6.
[Communications Biology] |
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| The authors discuss the current available repertoire of melanoma models, including two- and three-dimensional tissue cultures, organoids, genetically engineered mice and patient-derived xenograft.
[Nature Communications] |
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| Scientists discuss the essential role of mitochondria in regulating normal and abnormal skin physiology and the possibility of targeting this organelle in various skin disorders.
[Cell Death & Disease] |
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| A group of Australian scientists have caught the attention of NASA with a novel technology development that could potentially heal wounds in days rather than weeks without using stitches.
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| China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected.
[Nature News] |
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| 2020-10-12 – 2020-10-14
Paris, France |
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| | Bristol Myers Squibb РMontr̩al, Quebec, Canada |
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| | The Hormel Institute – Austin, Minnesota, United States |
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| | The Wistar Institute – Philadelphia, Pennsylvania, United States |
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| | Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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| | The Wistar Institute – Philadelphia, Pennsylvania, United States |
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| | University of California, Davis – Sacramento, California, United States |
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| | Taro Pharmaceuticals Inc. – Brampton, Ontario, Canada |
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| | Research Institute of the McGill University Health Centre – Montreal, Quebec, Canada |
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| | Amgen Inc. – South San Francisco, California, United States |
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| | Benaroya Research Institute – Seattle, Washington, United States |
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