 | | Vol. 6.22 – 22 June, 2020 |
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| Scientists suggested that urea cycle hyperreactivity and excessive polyamine generation in psoriatic keratinocytes promoted self-RNA sensation and highlighted protein phosphatase 6 deregulation in keratinocytes as a pivotal event that amplified the inflammatory circuits in psoriasis.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
| | Using thyroid cancer, melanoma, and colon cancer cell models, the authors showed that dabrafenib and trametinib induced robust apoptosis of cancer cells harboring both BRAF V600E and TERT promoter mutations but had little proapoptotic effect in cells harboring only BRAF V600E.
[Proceedings of the National Academy of Sciences of the United States of America] |
| | Researchers investigated the functional role of a nanosphere loaded with curcumin (CN) in the promotion of the motility of human mesenchymal stem cells (MSCs) during the skin wound healing process. They found that transplantation of umbilical cord blood-MSCs pre-treated with CN enhanced wound closure, granulation, and re-epithelialization at mouse skin wound sites.
[Cells] |
| | Investigators showed a decrease in reactive oxygen species production and tumor necrosis factor-α expression by methanolic extract (ME) in HaCaT under pro-oxidant and pro-inflammatory conditions, respectively. ME protected HaCaT against oxidative stress and inflammation.
[Antioxidants] |
| | A fucose-rich fucoidan was purified from brown seaweed Saccharina japonica, of which the UVB protective effect was investigated in vitro in keratinocytes of HaCaT cells and in vivo in zebrafish. The intracellular ROS levels and the viability of UVB-irradiated HaCaT cells were determined.
[Marine Drugs] |
| | Scientists combined intratumoral administration of the synthetic toll-like receptor 4 agonist glucopyranosyl lipid A with either active vaccination or adoptive transfer of tumor-specific CD8 T cells to mice bearing established melanomas.
[Npj Vaccines] |
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| Investigators combined lineage tracing in a spontaneous metastatic mouse model of melanoma, advanced imaging, and single-cell RNA sequencing approaches to search for pathophysiologically relevant melanoma cellular states.
[Cell Reports] |
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| To analyze the Hippo pathway in cutaneous melanoma, researchers generated a transcriptional signature of melanoma cells that overexpressed YAP, the key downstream Hippo pathway oncoprotein.
[Oncogene] |
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| Scientists showed a novel mechanism of melanoma resistance. miR-410-3p was induced by vemurafenib in melanoma cells via ER stress. It drove switching to the invasive phenotype that led to the response and resistance to BRAF inhibition.
[PLoS One] |
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| The authors investigated the potential anticancer effect of Abeliophyllum distichum organ extracts against human melanoma SK-MEL-2 cells. The methanol extract of A. distichum leaves exhibited dose- and time-dependent cytotoxicities against SK-MEL-2 cells but not against HDFa human dermal fibroblasts.
[Plants] |
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| Researchers performed a mutation significance study of over 1,000 melanoma exomes, combined with a multi-omic analysis of 470 cases from The Cancer Genome Atlas.
[Nature Cancer] |
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| The authors describe the role of Notch signaling in the skin, particularly focusing on the principal consequences associated with its alterations in five human skin diseases, in order to reorganize the current knowledge and to identify potential cellular mechanisms in common between these pathologies.
[International Journal of Molecular Sciences] |
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| Arcutis Biotherapeutics, Inc. announced it has completed enrollment of its Phase II proof of concept clinical trial evaluating roflumilast foam as a potential treatment for seborrheic dermatitis.
[Arcutis Biotherapeutics] |
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| The National Medical Products Administration in China has approved Dupixent® for the treatment of moderate-to-severe atopic dermatitis in adults whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable.
[Sanofi] |
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| A bipartisan group of US senators proposed sweeping—and controversial—changes in how the federal government manages academic research in the face of threats from other countries.
[ScienceInsider] |
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| 2020-07-16 – 2020-07-17
Virtual |
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| | Netherlands Cancer Institute – Amsterdam, Netherlands |
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| | Bristol Myers Squibb РMontr̩al, Quebec, Canada |
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| | The Hormel Institute – Austin, Minnesota, United States |
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| | Brigham and Women’s Hospital, Boston, Massachusetts |
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| | The Wistar Institute – Philadelphia, Pennsylvania, United States |
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| | The Wistar Institute – Philadelphia, Pennsylvania, United States |
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| | University of California, Davis – Sacramento, California, United States |
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| | Taro Pharmaceuticals Inc. – Brampton, Ontario, Canada |
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| | Amgen Inc – South San Francisco, California, United States |
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| | Benaroya Research Institute – Seattle, Washington, United States |
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Cancer Stem Cell News
Cell Therapy News
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Intestinal Cell News
Mammary Cell News
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