Dermal Cell News Volume 6.23 | Jun 29 2020

    By
    Justin.choi
    -
    0
    87







    2020-06-29 | DCN 6.23


    Dermal Cell News by STEMCELL Technologies
    Vol. 6.23 – 29 June, 2020
    TOP STORY

    Human Adipocyte Conditioned Medium Promotes In Vitro Fibroblast Conversion to Myofibroblasts

    Using a novel in-vitro 3D human adipocyte/pre-adipocyte spheroid model, researchers investigated whether adipocytes and their precursors secreted factors that affected human dermal fibroblast behavior.
    [Scientific Reports]

    Full Article

    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    PUBLICATIONSRanked by the impact factor of the journal

    Aspirin Protects Melanocytes and Keratinocytes against UVB-Induced DNA Damage In Vivo

    Scientists investigated whether the anti-inflammatory activities of aspirin (ASA) could protect against UVB-induced DNA damage and skin carcinogenesis. ASA reduced UVB-induced 8-oxoguanine and cyclobutane pyrimidine dimers in Melan-a melanocytes and HaCat keratinocytes.
    [Journal of investigative Dermatology]

    Abstract

    Tannic Acid-Reinforced Methacrylated Chitosan/Methacrylated Silk Fibroin Hydrogels with Multifunctionality for Accelerating Wound Healing

    It was demonstrated that the tannic acid-treated methacrylated chitosan/methacrylated silk fibroin hydrogels could significantly promote wound healing in a full-thickness skin defect model.
    [Carbohydrate Polymers]

    AbstractGraphical Abstract

    Dual Cross-Linked Honey Coupled 3D Antimicrobial Alginate Hydrogels for Cutaneous Wound Healing

    4% sodium alginate hydrogel coupled with honey treated wound closure achieved epithelial thickness resembling that of unwounded skin.
    [Materials Science & Engineering C-Materials For Biological Applications]

    AbstractGraphical Abstract

    Water Soluble PEGylated Phenothiazines as Valuable Building Blocks for Bio-Materials

    The biocompatibility of three new PEGylated phenothiazine derivatives was assessed on normal human dermal fibroblasts and human cervical cancer cells. The synthetized compounds showed the formation of luminescent aggregates and proved excellent biocompatibility on normal cells.
    [Materials Science & Engineering C-Materials For Biological Applications]

    AbstractGraphical Abstract

    Biofilm-Inspired Adhesive and Antibacterial Hydrogel with Tough Tissue Integration Performance for Sealing Hemostasis and Wound Healing

    Inspired by the strong adhesive mechanism of biofilm and mussels, researchers report a novel dual bionic adhesive hydrogel (DBAH) based on chitosan grafted with methacrylate, dopamine, and N-hydroxymethyl acrylamide. DBAH showed promise to provide a novel method for visceral hemostasis and accelerated healing of cutaneous skin wounds.
    [Bioactive Materials]

    Full ArticleGraphical Abstract

    PEGylated Lipid Nanocarrier for Enhancing Photodynamic Therapy of Skin Carcinoma Using Curcumin: In-Vitro/in-Vivo Studies and Histopathological Examination

    The authors designed PEGylated lipid nanocarriers loaded with curcumin (cur) to target skin cancer by photodynamic therapy. Cur is a polyphenolic compound having vast biological effects masked due to its low aqueous solubility.
    [Scientific Reports]

    Full Article

    Single-Cell Sequencing of Genomic DNA Resolves Sub-Clonal Heterogeneity in a Melanoma Cell Line

    Researchers performed shallow single-cell sequencing of genomic DNA across 1475 cells from a melanoma cell-line, COLO829 (a benchmark for evaluating somatic alterations) to resolve overall complexity and clonality.
    [Communications Biology]

    Full Article

    Watch 'collaborating to accelerate COVID-19 research'
    REVIEWS

    The Role of Kallikreins in Inflammatory Skin Disorders and their Potential as Therapeutic Targets

    The authors highlight the roles of kallikreins in skin homeostasis and pathologies. Due to their part in these skin disorders, inhibitors of the skin kallikreins have become attractive therapeutics.
    [Critical Reviews in Clinical Laboratory Sciences]

    Abstract

    Hypoxia-Inducible Factor-1: A Potential Pharmacological Target to Manage Psoriasis

    Scientists discuss the evidence showing the crucial role of hypoxia-inducible factor-1α in psoriasis along with interrelationship with other mediators/signaling pathways that may contribute to the development of psoriasis.
    [International Immunopharmacology]

    Abstract

    INDUSTRY AND POLICY NEWS

    AiViva Biopharma Announces Positive Data from Phase I/IIa Clinical Trial of AIV001 for Dermal Scarring and Wound Healing

    AiViva Biopharma Inc., has announced completion of its first Phase I/IIa study evaluating AIV001 in dermal scarring. A total of 16 subjects who were scheduled to undergo abdominoplasty were enrolled and completed in one of the four double-blind dose escalation or open label cohorts.
    [AiViva BioPharma]

    Press Release

    NIH’s New Sexual-Harassment Rules Are Still Too Weak, Say Critics

    On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
    [Nature News]

    Editorial

    FEATURED EVENT

    2020 Parenteral Drug Association (PDA) Virtual Pharmaceutical Manufacturing Data Science Workshop

    July 13 – July 16
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Epitope Discovery (Melanoma/Pancreatic Adenocarcinoma)

    King’s College London – London, United Kingdom

    Postdoc – Molecular Oncology and Immunology

    Netherlands Cancer Institute – Amsterdam, Netherlands

    Product Manager, Melanoma

    Bristol Myers Squibb РMontr̩al, Quebec, Canada

    Postdoctoral Associate – Melanoma

    The Hormel Institute – Austin, Minnesota, United States

    Postdoctoral Fellowship – Dermatology

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Dermal Cell News Twitter