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| Investigators showed that dietary glutamine supplementation significantly inhibited melanoma tumor growth, prolonged survival in a transgenic melanoma mouse model, and increased sensitivity to a BRAF inhibitor.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| By directly recruiting both syndecan-1 and CD44, laminin-332 G45 domain played a major role in regulating mechanisms underlying keratinocyte / extracellular matrix remodelling during wound repair.
[Matrix Biology] |
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| Researchers investigated the cytotoxic and genotoxic effects caused by Loxosceles laeta venom and sphingomyelinase D on human keratinocytes to better understand the dermonecrosis development mechanism.
[Archives of Toxicology] |
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| The functional analysis of CD133+ and CD133− cells in vitro and in vivo revealed that melanoma progression and treatment resistance were the consequences of CD133 signal to PI3K pathway.
[Oncogene] |
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| Researchers demonstrated that phenformin suppressed tumor growth and promoted keratinocyte differentiation in the DMBA/TPA two stage skin carcinogenesis mouse model.
[Journal of investigative Dermatology] |
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| Scientists demonstrated that chondroitin polymerizing factor was up-regulated in malignant melanoma tissues compared with the adjacent normal skin tissues and its high expression was correlated with more advanced T stage.
[Cell Death & Disease] |
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| CAF-CD38 promoted migration of primary fibroblasts toward melanoma cells. Further, in vitro paracrine effects of CAF-CD38 fostered tumor cell migration and invasion as well as endothelial cell tube formation.
[Laboratory investigation] |
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| Scientists uncovered a relationship between geometric features at perimeter regions of melanoma aggregates, and reprogramming to a stem cell-like state through histone marks H3K4Me2 and H3K9Ac.
[Communications Biology] |
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| The authors review the potential use of stem cells in elderly burn wounds, as well as the mechanisms by which mesenchymal stem cell- based therapies may impact burn wound healing in the elderly.
[International Journal of Molecular Sciences] |
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| Amniox Medical, Inc announced the initiation of the first of two planned multi center randomized controlled Phase III clinical trials that will be conducted at 20 investigational sites across the U.S with an enrollment of 220 patients in each trial. These trials will study the benefits and risks of using TTAX01 to achieve complete wound closure of complex non-healing diabetic foot ulcers with high-risk factors of ulcer depth indicating exposed bone, tendon, muscle, and/or joint capsule, and clinical suspicion of osteomyelitis.
[Amniox] |
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| Life sciences professors and other staff make contingency plans for more coronavirus-related disruptions in the coming school year.
[The Scientist] |
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| The UK government plans to set up an “office for talent” to oversee visas and make it easier to attract top scientists after Brexit, according to an R&D road map.
[ScienceInsider] |
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| October 20 – October 21
Virtual |
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| | The Wistar Institute – Philadelphia, Pennsylvania, United States |
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| | King’s College London – London, United Kingdom |
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| | Bristol Myers Squibb – Montréal, Quebec, Canada |
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| | The Hormel Institute – Austin, Minnesota, United States |
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| | Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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