Dermal Cell News Volume 6.26 | Jul 20 2020

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    DCN 6.26 | July 20 2020


    Dermal Cell News by STEMCELL Technologies
    Vol. 6.26 – 20 July, 2020
    TOP STORY

    Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells

    Investigators showed that arrector pili muscles and sympathetic nerves form a dual-component niche to modulate hair follicle stem cell activity.
    [Cell]

    Full ArticleGraphical Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Inhibition of Sonic Hedgehog Signaling via MAPK Activation Controls Chemotherapy-Induced Alopecia

    In organ-cultured human scalp hair follicles as well as in patients undergoing chemotherapy, reduced expression of SHH gene correlated with chemotherapy-induced hair follicle damage or the degree of chemotherapy-induced hair loss.
    [Journal of investigative Dermatology]

    Abstract

    Tetrahedral Framework Nucleic Acids Promote Scarless Healing of Cutaneous Wounds via the AKT-Signaling Pathway

    Scientists showed that tetrahedral framework nucleic acids, a type of self-assembled nucleic-acid material, had the ability to promote keratinocyte and fibroblast proliferation and migration in vitro.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Extracellular Vesicle‐Enclosed MiR‐486‐5p Mediates Wound Healing with Adipose‐Derived Stem Cells by Promoting Angiogenesis

    Researchers investigated the role of adipose‐derived stem cells‐extracellular vesicles in the cutaneous wound healing accompanied with the study on the specific cargo‐medicated effects on wound healing.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Adipose Stem Cells from Type 2 Diabetic Mice Exhibit Therapeutic Potential in Wound Healing

    This study compared the phenotypes of adipose tissue-derived mesenchymal stem cells harvested from high-fat diet, streptozotocin-induced type 2 diabetes (T2D) and healthy Chow diet-fed C57BL/6 mice in vitro and their therapeutic effects for the treatment of wound healing in a mouse model of T2D.
    [Stem Cell Research & Therapy]

    Full Article

    Mesenchymal Stromal Cell‐Derived Factors Promote the Colonization of Collagen 3D Scaffolds with Human Skin Cells

    Scientists investigated whether the therapeutic potential of an acellular porous scaffold made of type I collagen could be improved by the addition of a powerful trophic agent in the form of mesenchymal stromal cells conditioned medium in order to be used as an acellular scaffold for skin wound healing treatment.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Direct Identification of Bacterial and Human Proteins from Infected Wounds in Living 3D Skin Models

    Investigators demonstrated a novel and highly accurate approach for the rapid identification of ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) directly from infected wounds in 3D in vitro skin models.
    [Scientific Reports]

    Full Article

    Inactivating p53 Is Essential for Nerve Growth Factor Receptor to Promote Melanoma-Initiating Cell-Stemmed Tumorigenesis

    Knockdown of nerve growth factor receptor (NGFR) markedly reduced the size and number of spheroid formation of melanoma cells, which could be rescued by ectopically expressed NGFR.
    [Cell Death & Disease]

    Full Article

    Oral Exposure to BDE-209 Modulates Metastatic Spread of Melanoma in C57BL/6 Mice Inoculated with B16-F10 Cells

    In vitro studies showed that decabromodiphenyl ether interfered with murine melanoma cells, modulating cell death rates, proliferation and migration, important events for cancer progression.
    [Chemosphere]

    Abstract

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    REVIEWS

    Dialog between Skin and Its Microbiota: Emergence of “Cutaneous Bacterial Endocrinology”

    The authors demonstrate that there is a cutaneous microbial endocrinology and this emerging concept will certainly have important consequences in dermatology.
    [Experimental Dermatology]

    Abstract

    INDUSTRY AND POLICY NEWS

    IDEAYA Announces IDE196 Program Update and Clinical Protocol Criteria Met for Cohort Expansion in Skin Melanoma for Phase II GNAQ/11 Basket Trial

    IDEAYA Biosciences, Inc. announced that it has met the clinical protocol criteria for cohort expansion in the cutaneous melanoma cohort of its Phase II basket arm evaluating IDE196 monotherapy in solid tumors harboring GNAQ or GNA11 hotspot mutations (GNAQ/11).
    [IDEAYA]

    Press Release

    MC2 Therapeutics Announces Submission of Marketing Authorization Application in EU for Wynzora® Cream (50 µg/g calcipotriol and 0.5 mg/g Betamethasone (as Dipropionate))

    MC2 Therapeutics announced the submission of its Marketing Authorization Application in EU for Wynzora® Cream for the treatment of plaque psoriasis.
    [MC2 Therapeutics (BusinessWire, Inc.)]

    Press Release

    Open-Access Plan S to Allow Publishing in Any Journal

    Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing.
    [Nature News]

    Editorial

    FEATURED EVENT

    International Society for Stem Cell Research (ISSCR): Advances in Stem Cell Research: From Single Cells to Organs

    October 12 – October 14 2020
    Paris, France

    > See All Events

    JOB OPPORTUNITIES

    Research Group Leader – Senescence and Healing of Wounds

    Ludwig Boltzmann Gesellschaft GmbH – Vienna, Austria

    Postdoctoral Fellow – Novel Melanoma Therapies (Villanueva Lab)

    The Wistar Institute – Philadelphia, Pennsylvania, United States

    Postdoctoral Research Associate – Epitope Discovery (Melanoma/Pancreatic Adenocarcinoma)

    King’s College London – London, United Kingdom

    Product Manager, Melanoma

    Bristol Myers Squibb – Montréal, Quebec, Canada

    Postdoctoral Fellowship – Dermatology

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    > See All Jobs

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