 | | Vol. 6.27 – 27 July, 2020 |
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| A novel pro-inflammatory signaling pathway revealed that CDK4/6 phosphorylated EZH2 in keratinocytes, thereby triggering a methylation-induced activation of STAT3.
[Journal of Clinical Investigation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Finasteride was loaded in phospholipid vesicles and baicalin was co-loaded as an adjuvant. Their effect on hair growth was evaluated in vitro and in vivo.
[Nanoscale] |
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| Investigators proposed that psoriatic keratinocytes transferred miR-381-3p to CD4+ T cells via small extracellular vesicles, inducing Th1/Th17 polarization and promoting psoriasis development.
[Journal of investigative Dermatology] |
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| Using the kINPen argon plasma jet, a selective growth-reducing action of plasma treatment was identified in two squamous cell carcinoma cell lines in 2D and 3D cultures.
[Cancers] |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Scientists found that the loss of Sirt7 in mice impeded hair follicle life‐cycle transition from telogen to anagen phase, resulting in delay of hair growth.
[EMBO Journal] |
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| Researchers used CRISPR-Cas9 gene targeting to generate a library of 3D organotypic skin tissues that selectively differed in their capacity to produce glycan structures on the main types of N- and O-linked glycoproteins and glycolipids. This tissue library revealed distinct changes in skin formation associated with a loss of features for all tested glycoconjugates.
[Developmental Cell] |
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| Using lectin microarray, researchers performed a comprehensive glycan profiling of freshly isolated epidermal stem cells from young and old mouse skin.
[Aging Cell] |
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| The authors feature melanoma cell-derived exosomes with special emphasis on exosome-mediated signaling between melanoma cells and the host immune system.
[International Journal of Molecular Sciences] |
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| Checkmate Pharmaceuticals, Inc. announced that the FDA granted Fast Track designation to its product candidate, CMP-001, in combination with a programmed death receptor 1 (PD-1) blocking antibody for initial treatment of patients with unresectable stage III or stage IV melanoma; and treatment of patients with unresectable or metastatic melanoma refractory to prior anti-PD-1 blockade.
[Checkmate Pharmaceuticals (BusinessWire, Inc.)] |
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| The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
[ScienceInsider] |
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| Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
[The Scientist] |
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| September 10 – September 11
Virtual |
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| | The Francis Crick Institute – London, United Kingdom |
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| | MD Anderson Cancer Center – Houston, Texas, United States |
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| | Ludwig Boltzmann Gesellschaft GmbH – Vienna, Austria |
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| | The Wistar Institute – Philadelphia, Pennsylvania, United States |
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| | Bristol Myers Squibb – Montréal, Quebec, Canada |
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