Dermal Cell News Volume 6.30 | Aug 24 2020

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    Justin.choi
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    2020-08-24 | DCN 6.30


    Dermal Cell News by STEMCELL Technologies
    Vol. 6.30 – 24 August, 2020
    TOP STORY

    Lymph Protects Metastasizing Melanoma Cells from Ferroptosis

    Oleic acid protected melanoma cells from ferroptosis in an Acsl3-dependent manner and increased their capacity to form metastatic tumors.
    [Nature]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    LIN28B/Let-7 Control the Ability of Neonatal Murine Auditory Supporting Cells to Generate Hair Cells through mTOR Signaling

    Employing murine cochlear organoid and explant cultures to model mitotic and nonmitotic mechanisms of hair cell generation, researchers showed that loss of LIN28B function suppressed Akt-mTOR complex 1 activity and rendered young, immature supporting cells incapable of generating hair cells.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Identification of Novel Therapeutic Targets for Blocking Acantholysis in Pemphigus

    Scientists performed an unbiased screen in a complex biological system using 141 small molecule inhibitors from a chemical library. Specifically, they evaluated pemphigus vulgaris IgG‐induced desmoglein 3 internalization in HaCaT keratinocytes.
    [British Journal of Pharmacology]

    Abstract

    Cell Density-Dependent Proteolysis by HtrA1 Induces Translocation of Zyxin to the Nucleus and Increased Cell Survival

    Targeted degradomics correlated endogenous generation of the same zyxin fragment with increased cell density in human primary dermal fibroblasts.
    [Cell Death & Disease]

    Full Article

    Bioresponsive Supramolecular Hydrogels for Hemostasis, Infection Control and Accelerated Dermal Wound Healing

    Alginate/poly(N-vinyl caprolactam)-tannic acid displayed excellent free radical scavenging, anti-inflammatory, anti-bacterial, and cell proliferation activity towards the 3T3 fibroblast cell line.
    [Journal of Materials Chemistry B]

    AbstractGraphical Abstract

    Pseudomonas aeruginosa Virulence Proteins Pseudolysin and Protease IV Impede Cutaneous Wound Healing

    Pseudolysin and protease IV recombinant proteins were tested for their ability to modulate wound healing in several cell types of wound microenvironment in in vitro and in vivo models.
    [Laboratory Investigation]

    Full Article

    Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)

    Dorsal and abdomen skin tissues five days after birth were compared and the resulting DEGs were mainly enriched in keratin filament, epithelium cell differentiation, and epidermis development.
    [Scientific Reports]

    Full Article

    Co-Culture Model for Cutaneous Wound Healing to Assess a Porous Fiber-Based Drug Delivery System

    Researchers established an in vitro model for cutaneous wound healing, based on primary human dermal microvascular endothelial cells and primary human dermal fibroblasts to study wound healing-associated processes.
    [Tissue Engineering]

    Abstract

    Targeting Extracellular Matrix Remodeling Restores BRAF Inhibitor Sensitivity in BRAFi Resistant Melanoma

    Researchers investigated the role of ECM remodeling by the collagenase MT1-MMP in conferring resistance of BRAF-mutant melanoma to BRAF inhibitor therapy.
    [Clinical Cancer Research]

    Abstract

    Long Noncoding RNA TTN-AS1 Facilitates Tumorigenesis and Metastasis by Maintaining TTN Expression in Skin Cutaneous Melanoma

    Investigators found that the expression of titin (TTN) and lncRNA-TTN-AS1 had a significantly positive correlation in skin cutaneous melanoma cells.
    [Cell Death & Disease]

    Full Article

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    REVIEWS

    “Autoinflammatory Psoriasis” – Genetics and Biology of Pustular Psoriasis

    The authors discuss the presentation and clinical subtypes of pustular psoriasis, contribution of genetic predisposing variants, critical role of the IL-36 family of cytokines in disease pathophysiology, and treatment perspectives for pustular psoriasis.
    [Cellular & Molecular Immunology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Ultimovacs ASA Announces Completion of Patient Enrollment in Phase I Trial in Malignant Melanoma

    Ultimovacs ASA announced that patient enrollment has been completed in the ongoing US-based Phase I clinical trial testing Ultimovacs’ lead candidate, UV1, in combination with pembrolizumab as first line treatment in patients with metastatic malignant melanoma.
    [Ultimovacs ASA]

    Press Release

    UPM Brings Its First Clinical Product to Market – FibDex® Wound Dressing

    FibDex® wound dressing – made from nanofibrillar cellulose by UPM Biomedicals – has taken a step in its path to market, as medical device distributor Steripolar Oy now sells the product in Finland.
    [UPM Biomedicals]

    Press Release

    FEATURED EVENT

    Channels in Context: Structure and Function of Ion Channels in Macromolecular Complexes and Native Cells

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