 | | Vol. 6.32 – 14 September, 2020 |
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| Scientists used computational modeling, genetic manipulations and biophysical measurements to identify the biophysical underpinnings and biological consequences of tumor architectures.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
| | Researchers showed that the ability of outer root sheath cells to return to the SC state required suppression of a metabolic switch from glycolysis to oxidative phosphorylation and glutamine metabolism that occurred during early hair follicle stem cells lineage progression.
[Cell Metabolism] |
| | Novel chitosan/acellular dermal matrix stem cell delivery system significantly enhanced in vivo transplanted stem cell retention, promoted the vessel growth, and accelerated wound healing.
[Stem Cell Research & Therapy] |
| | Scientists developed an adult human skin model to study varicella-zoster virus and human cytomegalovirus in culture and in vivo.
[Journal of Virology] |
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| The authors revealed that genetically targeting the autophagy-related protein PIK3C3/VPS34 in melanoma and colorectal tumor cells, or treating tumor-bearing mice with selective inhibitors of the PIK3C3/VPS34 kinase activity, reprograms cold immune desert tumors into hot, inflamed immune infiltrated tumors.
[Autophagy] |
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| In vitro analyses determined that beta2 glycoprotein I (β2-GPI)-derived peptides reduced endothelial cell migration and sFlt-1 secretion. In a syngeneic, immunocompetent mouse melanoma model, these peptides also reduced melanoma growth in a dose-dependent response with increased sFlt-1 and attenuated vascular markers compared to negative controls.
[Cancer Letters] |
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| Scientists report that inhibiting palmitoyl-protein thioesterase 1 (PPT1), a target of chloroquine derivatives like hydroxychloroquine, enhanced the antitumor efficacy of anti–PD-1 Ab in melanoma.
[JCI Insight] |
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| The authors found that pellino ubiquitin e3 ligase was activated by innate pattern-recognition receptors, such as toll-like receptors, and was highly upregulated in human psoriatic skin lesions and murine psoriasis-like models.
[Experimental and Molecular Medicine] |
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| Researchers investigated the role of inflammasome sensor NACHT, LRR and PYD domains-containing protein (NLRP1) in acquired drug resistance to temozolomide in melanoma.
[Cancers] |
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| The sustained activation of type I interferon signaling in response to IFNβ mediated by the Stat1/Stat2/IRF9 complex enhanced the round amoeboid phenotype in melanoma cells, whereas its downregulation by various approaches promoted the mesenchymal invasive phenotype.
[Cancers] |
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| To investigate whether and how altered MYC phosphorylation might affect squamous cell carcinoma development, progression, and metastasis, scientists generated mice with inducible expression of MYCWT or MYCT58A in the basal layer of the skin epidermis.
[Oncogenesis] |
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| Researchers dissected the structural modifications in the tumor microenvironment due to the stromal expression of ADAM9 during melanoma progression.
[Biomolecules] |
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| The authors highlight the therapeutic potential of activin or activin antagonists for the treatment of impaired healing or excessive scarring and cancer, respectively.
[Trends in Molecular Medicine] |
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| Investigators highlight how tissue repair and cancer share cellular and molecular processes that are regulated in a wound but misregulated in cancer.
[Science Signaling] |
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| Researchers describe ectopic factors which drive human pluripotent stem cell differentiation to melanocytes in two dimensions, as well as in organoid models.
[Cancers] |
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| Kerecis® donated its Kerecis® Omega3 Burn product for burn victims of the fires in California, Oregon and Washington.
[Kerecis (Business Wire Inc.)] |
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| Partner Therapeutics, Inc. announced the resumption of enrollment in the National Cancer Institute sponsored Study EA61411 being conducted by ECOG-ACRIN Cancer Research Group and led by F. Stephen Hodi, MD, Director of the Center for Immuno-Oncology at Dana-Farber Cancer Institute and Ahmad Tarhini, MD, PhD., Professor of Oncologic Sciences and Director of Cutaneous and Clinical Translational Research at H. Lee Moffitt Cancer Center and Research Institute.
[Partner Therapeutics, Inc.] |
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| Avillion LLP announced the completion and results of its Phase II trial of sonelokinab, an investigational anti-IL-17 A/F Nanobody®, in patients with moderate to severe chronic plaque-type psoriasis.
[Avillion LLP] |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Karolinska Institute – Stockholm, Sweden |
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| | University of North Carolina at Chapel Hill – Chapel Hill, North Carolina, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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