 | | Vol. 6.34 – 28 September, 2020 |
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| Scientists utilized Raman spectro-microscopy for spatial mapping of metabolites within single cells, with the specific goal of identifying druggable metabolic susceptibilities from a series of patient-derived melanoma cell lines.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Adult scalp dermal progenitor cells and epidermal stem cells together with type I collagen as a scaffold material were used to reconstitute bilayer tissue-engineered skin substitutes in vitro.
[Stem Cell Research & Therapy] |
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| Functional epidermal three dimensional organoids with polarity were cultured using Wnt3a and the supernatant derived from interfollicular epidermal stem cells and fresh medium in a 1:1 ratio
[Stem Cell Research & Therapy] |
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| Investigators uncovered type XVII collagen (COL17) as a binding partner of the aPKC‐PAR complex, which is a key regulating factor of cell polarity. Immunoprecipitation‐immunoblot assay and protein‐protein binding assay revealed that COL17 interacted with aPKC and PAR3.
[Experimental Dermatology] |
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| By sequencing the exomes of the microdissected clusters of lymphoma cells from the epidermis and the dermis, scientists found that those microenvironments comprised different malignant clonotypes.
[Scientific Reports] |
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| The authors investigated whether the elimination of NG2+ hair follicle stem cells affected the induction of allergic contact dermatitis, using a herpes simplex virus thymidine kinase/ganciclovir suicide gene system.
[International Journal of Molecular Sciences] |
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| Investigators showed that NRF2 suppressed the activity of the melanocyte lineage marker MITF in melanoma, thereby reducing the expression of pigmentation markers.
[Oncogene] |
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| The authors report that A20 played an oncogenic role in melanoma. They first found that the expression of A20 was significantly up-regulated in melanoma cell lines.
[Cell Death & Disease] |
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| Investigators performed methylation loci fine-mapping to search the top signals in the entire CYP2S1 gene region, and further carried out gene expression assay, cell proliferation, apoptosis, differentiation and migration in CYP2S1 overexpressed and silenced human keratinocytes.
[Epigenetics] |
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| Transforming growth factor-β1 (TGF-β1) was increased in moderate-severe obstructive sleep apnea (OSA) patients vs. non-OSA or mild OSA patients with cutaneous melanoma.
[Scientific Reports] |
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| Researchers showed that pharmacological inhibition of BRAF-V600E or ERK1/2 in melanoma cells increased PARK2 expression.
[Journal of Biological Chemistry] |
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| Scientists investigated the potential and mechanisms of anti-melanoma action of minocycline.
[International Journal of Molecular Sciences] |
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| The authors focus on how neurohormones impact human skin physiology and pathology. They highlight basic concepts, major open questions, and translational research perspectives in cutaneous neuroendocrinology and argue that greater emphasis on neuroendocrine human skin research will foster the development of novel dermatological therapies.
[Trends in Molecular Medicine] |
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| In this review, focusing on the skin, scientists investigate potential key mechanisms that ensure tissue homeostasis despite the presence of mutant cells, as well as critical factors that may nudge the balance from homeostasis to tumor formation.
[Journal of Internal Medicine] |
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| Misonix, Inc. announced that it has entered into an exclusive supply and distribution agreement with Gunze Ltd. for TheraGenesis® Bilayer Wound Matrix. TheraGenesis® is a proprietary, FDA cleared, porcine tendon-derived collagen wound matrix with a silicone film layer used to treat trauma, burn and reconstructive wounds.
[Misonix, Inc.] |
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| May 16 – May 21, 2021
Lucca, Italy |
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| | Sanford Burnham Prebys Medical Discovery Institute – La Jolla, California, United States |
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| | University of British Columbia- Vancouver, British Columbia, Canada |
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| | Case Western Reserve University- Cleveland, Ohio, United States |
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| | University of Michigan- Ann Arbor, Michigan, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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