 | | Vol. 6.35 – 5 October, 2020 |
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| In vitro human keratinocyte cell culture, ex vivo human skin organ explants and the eczema prone Nc/Tnd mouse were used as model systems to assess type-2 promoting immune responses to S. aureus.
[Journal of Allergy and Clinical Immunology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
| | Scientists found that surface VEGF receptor-2 (VEGFR-2) could be mobile or exhibit restricted mobility and be monomeric or non-monomeric, with a complex interplay between the two.
[Cell Reports] |
| | Researchers demonstrated that among 18 markers of terminally differentiated keratinocytes of stratum granulosum and stratum corneum in vivo, only four (CDSN, KPRP, LCE1C, and SPRR4) have reproduced their expression pattern in vitro.
[Experimental Dermatology] |
| | Filamentous and picoplanktonic cyanobacteria extracts were analyzed for their pigment profile, phenolic content, antioxidant potential, cytotoxicity against keratinocytes, fibroblasts, endothelial cells and capacity to inhibit hyaluronidase.
[Marine Drugs] |
| | Lab-on-a-chip technology was used to investigate the effects of basic fibroblast growth factor, mitomycin C, MEK1/2 inhibitor and fetal calf serum on human dermal fibroblast cell migration.
[Scientific Reports] |
| | The proliferative activity of Bidens pilosa, Calophyllum inophyllum and Fagraea berteroana on dermal papilla cells was assessed via MTT assay and molecular targets were evaluated by RT-qPCR analysis of seven factors involved in the modulation of the hair cycle, CCND1, LEF1, DKK1, WNT5A PPARD, TGFÎ’1, PPARD and RSPO2.
[Molecules] |
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Scientists found that EZH2 and H3K27me3 were both overexpressed in the epidermis of psoriatic lesional skin compared to normal skin. In vitro, the expression of EZH2 and H3K27me3 was stimulated in human keratinocytes treated with a mixture of psoriasis-related cytokines pool.
[Cell Death & Disease] |
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| The authors showed that downregulation of galcb, a zebrafish orthologue of human beta-galactosylceramidase (GALC), affects melanoblast and melanocyte differentiation in zebrafish embryos, suggesting a possible role for GALC in melanoma.
[Cancer Research] |
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| Researchers presented preclinical data on domatinostat efficacy and mode of action in merkel cell carcinoma. Single-cell RNA-sequencing revealed a distinct gene expression signature of antigen processing and presentation, cell cycle arrest, and execution phase of apoptosis upon treatment.
[Journal of Investigative Dermatology] |
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| The miR-146a-5p-regulated NFkB signaling network was identified in drug-resistant cell lines and melanoma tumor samples by expression profiling and knock-in and knock-out studies.
[Cell Communication and Signaling] |
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| Investigators highlight nanotechnology-related developments for psoriasis treatment, including patented delivery systems and therapeutics currently in clinical trials.
[Drug Discovery Today] |
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| The authors present the oncogenic protein tyrosine phosphatases contributing to melanoma progression and provide, where available, a description of new inhibitory strategies designed against these enzymes and possibly useful in melanoma treatment.
[Cancers] |
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| Bristol Myers Squibb announced results for the co-primary endpoint for CheckMate -915, a randomized Phase III study evaluating Opdivo plus Yervoy versus Opdivo for patients who had a complete surgical removal of stage IIIb/c/d or stage IV melanoma.
[Bristol Myers Squibb] |
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| AiViva Biopharma Inc announced that it had begun dosing patients diagnosed with superficial or nodular basal cell carcinoma with AIV001. AIV001 is AiViva’s novel intradermally administered product designed for local, prolonged treatment effect for dermatological conditions.
[AiViva Biopharma, Inc.] |
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| October 13 – October 14
Virtual |
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| | University of California, Davis – Sacramento, California, United States |
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| | Sanford Burnham Prebys Medical Discovery Institute – La Jolla, California, United States |
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| | University of British Columbia- Vancouver, British Columbia, Canada |
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| | Case Western Reserve University- Cleveland, Ohio, United States |
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| | University of Michigan- Ann Arbor, Michigan, United States |
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Cancer Stem Cell News
Cell Therapy News
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Endothelial Cell News
ESC & iPSC News
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Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
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