Dermal Cell News Volume 6.37 | Oct 26 2020

May 12, 2022

2020-10-26 | DCN 6.37

Dermal Cell News by STEMCELL Technologies

Vol. 6.37 – 26 October, 2020

TOP STORY

Galectin-7 Downregulation in Lesional Keratinocytes Contributes to Enhanced IL-17A Signaling and Skin Pathology in Psoriasis

Scientists found that the expression of galectin-7 was reduced in the skin lesions of patients with psoriasis. IL-17A and TNF-α, two cytokines intimately involved in the development of psoriatic lesions, suppressed galectin-7 expression in human primary keratinocytes and the immortalized human keratinocyte cell line HaCaT.
[Journal of Clinical Investigation]

Abstract Full Article Graphical Abstract

Guide to everything you need to know about cell separation.

PUBLICATIONSRanked by the impact factor of the journal

DERMAL STEM CELLS & TISSUE REGENERATION

Contribution of GATA6 to Homeostasis of the Human Upper Pilosebaceous Unit and Acne Pathogenesis

GATA6 was down-regulated in acne when expressed in the upper pilosebaceous unit of normal human skin. GATA6 controls keratinocyte proliferation and differentiation to prevent hyperkeratinization of the infundibulum, which is the primary pathological event in acne.
[Nature Communications]

Full Article

Dissecting the Roles of GRK2 and GRK3 in μ-Opioid Receptor Internalization and β-Arrestin2 Recruitment Using CRISPR/Cas9-Edited HEK293 Cells

Using CRISPR/Cas9-mediated genome editing, researchers established HEK293 cells with knockout of GRK2, GRK3 or both to dissect their individual contributions in β-arrestin2 recruitment and μ-OR internalization upon stimulation with four different agonists.
[Scientific Reports]

Abstract

The Long Noncoding RNA PDK1-AS/miR-125b-5p/VEGFA Axis Modulates Human Dermal Microvascular Endothelial Cell and Human Umbilical Vein Endothelial Cell Angiogenesis after Thermal Injury

Investigators identified the role of long noncoding RNAs related to the function of miR‐125b and vascular endothelial growth factor in burn wound repair and the underlying mechanism.
[Journal of Cellular Physiology]

Abstract

Coordination Between Cell Motility and Cell Cycle Progression in Keratinocyte Sheets via Cell-Cell Adhesion and Rac1

Scientists found that keratinocyte sheets exhibited time-dependent coordination of collective cell movement and cell cycle progression after seeding cells.
[iScience]

Full Article Graphical Abstract

SKIN CANCERS & DISORDERS

WNT11-FZD7-DAAM1 Signaling Supports Tumor Initiating Abilities and Melanoma Amoeboid Invasion

Researchers showed that WNT11-FZD7-DAAM1 activated Rho-ROCK1/2-Myosin II and played a crucial role in regulating tumor-initiating potential, local invasion and distant metastasis formation.
[Nature Communications]

Full Article Press Release

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma

The authors identified KMT2D as a potent tumor suppressor in melanoma through an in vivo epigenome-focused pooled RNAi screen and confirmed the finding by using a genetically engineered mouse model based on conditional and melanocyte-specific deletion of KMT2D.
[Cell Reports]

Full Article Graphical Abstract

Melanoma Stem Cell-Like Phenotype and Significant Suppression of Immune Response within a Tumor Are Regulated by TRIM28 Protein

TRIM28 high level related to higher melanoma stemness as measured with several distinct scores and TRIM28^HIGH-expressing melanoma cell lines possess the greater potential of melanosphere formation.
[Cancers]

Full Article

Inhibition of Melanoma Cell Migration and Invasion Targeting the Hypoxic Tumor Associated CAXII

Researchers demonstrated that malignant melanoma cell motility was impaired by targeting carbonic anhydrase IX via either carbonic anhydrase inhibitors or through the inhibition of the Hedgehog pathway.
[Cancers]

Full Article Graphical Abstract

Response of Human Melanoma Cell Lines to Interferon-Beta Gene Transfer Mediated by a Modified Adenoviral Vector

The AdRGD-PG-hIFNβ vector encoding the human interferon-β cDNA was used to transduce human melanoma cell lines SK-MEL-05 and SK-MEL-147. In vitro, cell death was induced in more than 80% of the cells and correlated with elevated annexinV staining and caspase 3/7 activity.
[Scientific Reports]

Full Article

REVIEWS

Advances in Resolving the Heterogeneity and Dynamics of Keratinocyte Differentiation

Investigators highlight major recent discoveries that illuminate the dynamics and cellular mechanisms that govern keratinocyte differentiation in live mammalian skin and discuss the broader implications of these findings for the understanding of epithelial and stem cell biology in general.
[Current Opinion in Cell Biology]

Abstract

INDUSTRY AND POLICY NEWS

Evelo Biosciences Completes Enrollment in Phase Ib Clinical Trial Cohort Evaluating EDP1815 in Atopic Dermatitis

Evelo Biosciences, Inc. completed enrollment of 24 patients in the Phase Ib clinical trial cohort evaluating EDP1815 in mild to moderate atopic dermatitis. EDP1815 is an investigational oral biologic in development for the treatment of inflammatory diseases.
[Evelo Biosciences, Inc.]

Press Release

Arcutis Completes Enrollment in Phase I/IIb Study Evaluating ARQ-252 in Chronic Hand Eczema

Arcutis Biotherapeutics, Inc. completed enrollment in its Phase I/IIb study of ARQ-252, a potent and highly selective topical small molecule inhibitor of Janus kinase type 1, in adult patients with chronic hand eczema. Arcutis updated its projections and now anticipates announcing topline data from this trial by mid-2021.
[Arcutis Biotherapeutics, Inc.]

Press Release

FEATURED EVENT

Galectin-7 Downregulation in Lesional Keratinocytes Contributes to Enhanced IL-17A Signaling and Skin Pathology in Psoriasis

Contribution of GATA6 to Homeostasis of the Human Upper Pilosebaceous Unit and Acne Pathogenesis

Dissecting the Roles of GRK2 and GRK3 in μ-Opioid Receptor Internalization and β-Arrestin2 Recruitment Using CRISPR/Cas9-Edited HEK293 Cells

The Long Noncoding RNA PDK1-AS/miR-125b-5p/VEGFA Axis Modulates Human Dermal Microvascular Endothelial Cell and Human Umbilical Vein Endothelial Cell Angiogenesis after Thermal Injury

Coordination Between Cell Motility and Cell Cycle Progression in Keratinocyte Sheets via Cell-Cell Adhesion and Rac1

WNT11-FZD7-DAAM1 Signaling Supports Tumor Initiating Abilities and Melanoma Amoeboid Invasion

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma

Melanoma Stem Cell-Like Phenotype and Significant Suppression of Immune Response within a Tumor Are Regulated by TRIM28 Protein

Inhibition of Melanoma Cell Migration and Invasion Targeting the Hypoxic Tumor Associated CAXII

Response of Human Melanoma Cell Lines to Interferon-Beta Gene Transfer Mediated by a Modified Adenoviral Vector

Advances in Resolving the Heterogeneity and Dynamics of Keratinocyte Differentiation

Evelo Biosciences Completes Enrollment in Phase Ib Clinical Trial Cohort Evaluating EDP1815 in Atopic Dermatitis

Arcutis Completes Enrollment in Phase I/IIb Study Evaluating ARQ-252 in Chronic Hand Eczema

Keystone Symposia: Tumor Metabolism and the Microenvironment

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Postdoctoral Researcher – Inflammatory Skin Diseases

Researcher – Skin RNA Biology

Instructor – Dermatology

Postdoctoral Researcher – Inflammatory Skin Diseases

Postdoctoral Scientists – Stem Cell Factors in Epithelial Cancers

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