Dermal Cell News Volume 6.39 | Nov 9 2020

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    2020-11-09 | DCN 6.39


    Dermal Cell News by STEMCELL Technologies
    Vol. 6.39 – 9 November, 2020
    TOP STORY

    Tp63-Expressing Adult Epithelial Stem Cells Cross Lineages Boundaries Revealing Latent Hairy Skin Competence

    Scientists demonstrated that epithelial stem cells of non-skin origin that express the transcription factor Tp63, a master gene for the development of epidermis and its appendages, could respond to skin morphogenetic signals.
    [Nature Communications]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal
    DERMAL STEM CELLS & TISSUE REGENERATION

    Hair Graying with Aging in Mice Carrying Oncogenic RET

    Researchers found that the microscopic appearance of hair follicles without melanocyte stem cells and descendant melanocytes as well as macroscopic appearances of hair graying in RET‐transgenic mice carrying RET oncogene were in accordance with previously reported results for hair graying in humans.
    [Aging Cell]

    Full Article

    In Vitro Protective Effects of Paeonia mascula Subsp. Hellenica Callus Extract on Human Keratinocytes

    Investigators presented the development of the Paeonia mascula subsp. Hellenica callus extract and its pleiotropic bioactivity on human primary keratinocytes exploring its potential application as an active agent in skin-related products.
    [Scientific Reports]

    Full Article

    Sodium Alginate/Collagen Hydrogel Loaded with Human Umbilical Cord Mesenchymal Stem Cells Promotes Wound Healing and Skin Remodeling

    An injectable hydrogel composed of sodium alginate and collagen type I was synthesized as a tissue scaffold to improve the efficacy of stem cells in a full-thickness excision wound model.
    [Cell and Tissue Research]

    Abstract

    SKIN CANCERS & DISORDERS

    LncRNA LHFPL3-AS1 Contributes to Tumorigenesis of Melanoma Stem Cells via the miR-181a-5p/BCL2 Pathway

    Scientists revealed that the lncRNA LHFPL3-AS1-long, generated from the polypyrimidine tract binding protein 1-mediated splicing of the LHFPL3-AS1 precursor, upregulated B-cell lymphoma-2 (BCL2) protein to contribute to tumorigenesis of melanoma stem cells.
    [Cell Death & Disease]

    Full Article

    Targeting PSMD14 Inhibits Melanoma Growth through SMAD3 Stabilization

    The authors focused on deubiquitinating enzymes, which regulate protein stability through ubiquitin–proteasome systems, and identified 26S proteasome non-ATPase regulatory subunit 14 (PSMD14) as a molecule related to melanoma growth using siRNA library screening.
    [Scientific Reports]

    Full Article

    The Delay in Cell Death Caused by the Induction of Autophagy by P2Et Extract Is Essential for the Generation of Immunogenic Signals in Melanoma Cells

    Researchers determined the role of autophagy in apoptosis and the generation of immunogenic signals using murine wild-type B16-F10 melanoma cells and cells with beclin-1 gene knockout.
    [Apoptosis]

    Abstract

    Vitexin Protects Melanocytes from Oxidative Stress via Activating MAPK-Nrf2/ARE Pathway

    The authors investigated the antioxidant effect of vitexin-activated mitogen-activated protein kinase-Nrf2/ARE axis in vitiligo.
    [Immunopharmacology and Immunotoxicology]

    Abstract

    Guide to everything you need to know about cell separation.
    REVIEWS

    From Grafts to Human Bioengineered Vascularized Skin Substitutes

    The authors outlines the advances, including commercially available skin substitutes, to finally focus on future tissue engineering perspectives leading to the creation of autologous prevascularized skin equivalents with a hypodermal-like layer to achieve an exemplary skin substitute that fulfills all the biological characteristics of native skin and contributes to wound healing.
    [International Journal of Molecular Sciences]

    Full Article

    Gene Regulation Using Spherical Nucleic Acids to Treat Skin Disorders

    Scientists describe the production, structure and properties of spherical nucleic acids (SNAs); detail the mechanism of SNA uptake in keratinocytes, regulated by scavenger receptors; and report how SNAs have been topically applied and intralesionally injected for skin disorders.
    [Pharmaceuticals]

    Full ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    LifeNet Health Is Reimagining Wound Healing with MatrionTM, the First Fully Intact and Complete Placental Membrane

    LifeNet Healt created new possibilities in patient care with MatrionTM, a breakthrough decellularized placental membrane for wound healing.
    [LifeNet Healt]

    Press Release

    FEATURED EVENT

    The American Association for Cancer Research (AACR) Annual Meeting 2021

    April 9 – April 14, 2021
    Washington, DC, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Laboratory Assistant – Dermatology Research

    University of California, San Diego – La Jolla, California, United States

    Research Faculty Positions – Melanoma

    Duke University – Durham, North Carolina, United States

    Senior Group Leader – Rare Cancers

    IRCCS Candiolo Cancer Institute – Candiolo, Italy

    Researcher – Skin RNA Biology

    Uppsala University – Uppsala, Sweden

    Instructor – Dermatology

    University of Alabama at Birmingham – Birmingham, Alabama, United States

    > See All Jobs

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