| Vol. 6.39 – 9 November, 2020 |
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| Scientists demonstrated that epithelial stem cells of non-skin origin that express the transcription factor Tp63, a master gene for the development of epidermis and its appendages, could respond to skin morphogenetic signals. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| DERMAL STEM CELLS & TISSUE REGENERATION |
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| Researchers found that the microscopic appearance of hair follicles without melanocyte stem cells and descendant melanocytes as well as macroscopic appearances of hair graying in RET‐transgenic mice carrying RET oncogene were in accordance with previously reported results for hair graying in humans. [Aging Cell] |
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| Investigators presented the development of the Paeonia mascula subsp. Hellenica callus extract and its pleiotropic bioactivity on human primary keratinocytes exploring its potential application as an active agent in skin-related products. [Scientific Reports] |
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| An injectable hydrogel composed of sodium alginate and collagen type I was synthesized as a tissue scaffold to improve the efficacy of stem cells in a full-thickness excision wound model. [Cell and Tissue Research] |
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| Scientists revealed that the lncRNA LHFPL3-AS1-long, generated from the polypyrimidine tract binding protein 1-mediated splicing of the LHFPL3-AS1 precursor, upregulated B-cell lymphoma-2 (BCL2) protein to contribute to tumorigenesis of melanoma stem cells. [Cell Death & Disease] |
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| The authors focused on deubiquitinating enzymes, which regulate protein stability through ubiquitin–proteasome systems, and identified 26S proteasome non-ATPase regulatory subunit 14 (PSMD14) as a molecule related to melanoma growth using siRNA library screening. [Scientific Reports] |
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| Researchers determined the role of autophagy in apoptosis and the generation of immunogenic signals using murine wild-type B16-F10 melanoma cells and cells with beclin-1 gene knockout. [Apoptosis] |
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| The authors investigated the antioxidant effect of vitexin-activated mitogen-activated protein kinase-Nrf2/ARE axis in vitiligo. [Immunopharmacology and Immunotoxicology] |
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| The authors outlines the advances, including commercially available skin substitutes, to finally focus on future tissue engineering perspectives leading to the creation of autologous prevascularized skin equivalents with a hypodermal-like layer to achieve an exemplary skin substitute that fulfills all the biological characteristics of native skin and contributes to wound healing. [International Journal of Molecular Sciences] |
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| Scientists describe the production, structure and properties of spherical nucleic acids (SNAs); detail the mechanism of SNA uptake in keratinocytes, regulated by scavenger receptors; and report how SNAs have been topically applied and intralesionally injected for skin disorders. [Pharmaceuticals] |
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| LifeNet Healt created new possibilities in patient care with MatrionTM, a breakthrough decellularized placental membrane for wound healing. [LifeNet Healt] |
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| April 9 – April 14, 2021 Washington, DC, United States |
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| University of California, San Diego – La Jolla, California, United States |
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| Duke University – Durham, North Carolina, United States |
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| IRCCS Candiolo Cancer Institute – Candiolo, Italy |
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| Uppsala University – Uppsala, Sweden |
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| University of Alabama at Birmingham – Birmingham, Alabama, United States |
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