 | | Vol. 6.43 – 7 December, 2020 |
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| Using two distinct mouse lines, scientists found that increasing contractility of differentiated cells resulted in non-cell-autonomous hyperproliferation of stem cells and prevented their commitment to a hair follicle lineage.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
| | The application of 3D-printed medical-grade polycaprolactone dressings decreased wound contracture and significantly improved skin regeneration through granulation and re-epithelialization compared to control groups.
[Biomaterials] |
| | Scientists chose the diabetic wound as a representative injury model to explore the actual therapeutic results of tissue injury by injectable hypoxia-induced hydrogels.
[ACS Applied Materials & Interfaces] |
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| Researchers investigated five BRAFV600E melanoma cell lines derived from drug-naïve tumor specimens to assess cell death response to encorafenib, a recently FDA-approved BRAFV600E inhibitor.
[Cancer Letters] |
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| Ceramide Kinase‐Like Protein (CERKL) expression was determined by RNA‐Seq, qPCR, and immunohistochemistry. CERKL was knocked down in cutaneous squamous cell carcinoma cells using siRNA.
[British Journal of Dermatology] |
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| Investigators used brain metastasizing variants from three human melanomas to explore the functional role of Aldolase C in the formation and maintenance of melanoma brain metastasis.
[Molecular Oncology] |
| | Spermidine bioactivity was employed for targeting tumor cell over-expressed polyamine transport system and for effective delivery of functional miRNA into melanoma cells.
[Scientific Reports] |
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| The anti-cancer mechanism of Isoquercitrin (IQ) against human melanoma, particularly its effect on the mitochondria-mediated apoptosis, was investigated. Treatment with IQ at 25 μM concentration effectively inhibited the proliferation of SK-MEL-2 skin cancer cells while the same concentration did not exhibit cytotoxicity against human keratinocytes HaCaT.
[Nutrients] |
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| Scientists investigated the effect of the development of psoriasis vulgaris and psoriatic arthritis on the composition and physicochemical properties of skin cell membranes and blood cells.
[International Journal of Molecular Sciences] |
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| The authors summarize the newly identified changes in the metabolism, composition, and function of HDL in allergies and skin diseases. They also highlight the possible pathophysiological consequences with a focus on HDL-mediated immunomodulatory activities.
[Biomedicines] |
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| Scientists combine recent and older data on the organization of the dermal-epidermal junction, its mechanical properties and role in mechanotransduction, its involvement in regeneration, and its fate during the aging process.
[Biomolecules] |
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| Brickell Biotech, Inc. announced dosing of the first patient in its second US pivotal Phase III clinical study evaluating sofpironium bromide gel, 15% in approximately 350 subjects aged nine and older with primary axillary hyperhidrosis.
[Brickell Biotech, Inc.] |
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| Evelo Biosciences, Inc. announced that it is recruiting ahead of schedule and has completed enrollment of the patients necessary for the interim data readout in Phase II clinical trial evaluating EDP1815 for the treatment of mild to moderate psoriasis. The interim data readout includes initial safety and efficacy data for the first 113 patients enrolled in the trial.
[Evelo Biosciences, Inc. (Globe Newswire, Inc)] |
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| Sol-Gel Technologies, Ltd. announced that its New Drug Application for Twyneo®, an investigational proprietary fixed-dose combination of 3% encapsulated benzoyl peroxide and 0.1% encapsulated tretinoin cream for the treatment of acne vulgaris, has been accepted for filing by the US FDA.
[Sol-Gel Technologies, Ltd.] |
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| June 6 – June 11, 2021
Castelldefels, Spain |
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| | Karolinska Institute – Stockholm, Sweden |
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| | University of Cincinnati – Cincinnati, Ohio, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | University of Copenhagen – Copenhagen, Denmark |
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