 | | Vol. 7.03 – 25 January, 2021 |
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| Investigators confirmed that nitrogen mustard (NM) dose-dependently caused cell death and induced autophagy in keratinocytes. Suppression of autophagy by 3-methyladenine, chloroquine, and bafilomycin A1 or ATG5 siRNA attenuated NM-induced keratinocyte cell death.
[Signal Transduction and Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
| | Scientists showed that hundreds of intronic polyadenylation sites were differentially used during keratinocyte differentiation, which was accompanied by downregulation of the Cleavage and Polyadenylation Specificity Factor (CPSF) complex.
[Nature Communications] |
| | Human keratinocytes cells were used as an experimental model for studies on the effects of platelet-rich plasma on cell proliferation, migration, collagen biosynthesis, prolidase activity, and its expression and anabolic signaling.
[International Journal of Molecular Sciences] |
| | The authors indicated that chondroitin 6-sulfate repressed keratinocyte proliferation in normal skin and that the expression level of chondroitin 6-O-sulfotransferase-1 may be associated with susceptibility to psoriasis.
[Communications Biology] |
| | Researchers investigated how micro skin tissue column treatment affected the different cellular processes involved in wound healing.
[Scientific Reports] |
| | The authors demonstrated that Pannexin 3 (Panx3) regulated skin development by modulating the transcription factor, Epiprofin (Epfn). In cell culture, Panx3 overexpression promoted HaCaT cell differentiation, cell cycle exit, and enhanced Epfn expression.
[Scientific Reports] |
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| In melanoma cells, constitutive photomorphogenesis 9 signalosome 6 (CSN6) knockdown remarkably inhibited cell proliferation, tumorigenicity, migration, and invasion, whereas CSN6 recovery rescued the proliferative and metastatic abilities.
[Cell Death & Disease] |
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| Researchers showed that the small molecule triptonide robustly suppressed melanoma cell tumorigenicity, migration, and invasion.
[Biochemical Pharmacology] |
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| The authors investigated the role of nectin cell adhesion molecule 4 (NECTIN4) in melanoma and its potency as a therapeutic target using 126 melanoma samples and BRAFi-resistant cells.
[International Journal of Molecular Sciences] |
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| Scientists investigate the trends in injectable scaffolds for adipose-derived stromal cell (ASC) delivery in the dermis and injectable or implantable scaffolds for ASC delivery in the subcutis.
[Stem Cell Research & Therapy] |
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| The authors identified a novel SphK1-targeting microRNA, microRNA-6784 (miR-6784). They showed that miR-6784 was located at the cytoplasm of A431 skin squamous cell carcinoma cells.
[Aging] |
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| Abeona Therapeutics, Inc. announced that the company held a successful Type B meeting with the FDA to align with the agency on the company’s proposal regarding co-primary endpoints for the pivotal Phase III VIITAL™ study of EB-101 in RDEB.
[Abeona Therapeutics, Inc.] |
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| Pulse Biosciences, Inc. announced Conformité Européene (CE) mark approval for the CellFX® System. This allows the company to proceed with its planned controlled launch of the CellFX® System to medical practices within the European Union for the treatment of general dermatologic conditions.
[Pulse Biosciences, Inc.] |
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| February 3 – 5, 2021
Virtual |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | Novo Nordisk – Copenhagen, Denmark |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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