 | | Vol. 7.04 – 1 February, 2021 |
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| Researchers found that keratinocytes adapted to increasing matrix stiffness by forming a rigid, interconnected network of keratin bundles, in conjunction with F-actin stress fiber formation and increased cell stiffness.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
| | Using regulated overexpression or conditional ablation in the context of chemical cutaneous carcinogenesis, investigators showed that tristetraprolin represented a critical regulator of skin tumorigenesis.
[JCI Insight] |
| | The authors applied a novel nano-biomechanical technique on cell-embedded collagen hydrogels in combination with mathematical modeling and numerical simulation to measure contraction forces of normal human dermal fibroblasts.
[Biochimica Et Biophysica Acta-Molecular Cell Research] |
| | Scientists used epithelial cells producing mutant keratin itermediate filament polypeptides that have been identified as the cause of the hereditary blister-forming skin disease epidermolysis bullosa simplex.
[Scientific Reports] |
| | The authors investigated the potential effect of short-term high-intensity ultrasound treatment for the acceleration of wound healing in an in vitro wound model and dermal equivalent, both comprised of human dermal fibroblasts.
[Scientific Reports] |
| | Scientists explored the signaling pathways associated with the effects of tumor necrosis factor alpha (TNF-α) on matrix metalloproteinase-1 (MMP-1) and MMP-3 expression in the human dermal fibroblast cell line CCD-966SK.
[Chemico-Biological Interactions] |
| | Researchers evaluated the effects of myristoleic acid on anagen-activating signaling pathways in dermal papilla cells.
[Biomolecules & Therapeutics] |
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| Investigators demonstrated the potential of skin-derived glucocorticoids and their role in the regulation of physiological and prevalent inflammatory skin conditions.
[Science Advances] |
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| Scientists modified anti-Braf siRNA with tetrahedral framework nucleic acids to downregulate the target Braf gene.
[ACS Applied Materials & Interfaces] |
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| The authors demonstrated that the endothelin-endothelin receptor B signaling pathway conferred resistance to MAPK pathway inhibitors in BRAF mutated melanoma.
[Oncogene] |
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| Investigators showed that out of 19 evaluated hnRNPs, hnRNP A2B1 was significantly upregulated in melanoma stem cells compared with non-stem cells, suggesting an important role of hnRNP A2B1 in cancer stem cells.
[Stem Cell Research & Therapy] |
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| The authors explored the role of KLF5 in the proliferation and metastasis of melanoma. Bioinformatics analysis was performed to detect WWP1, BAP1 and KLF5 expression in melanoma, followed by expression determination on clinical tissues from melanoma patients and cancer cells.
[Experimental Cell Research] |
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| Investigators summarize the current knowledge of aryl hydrocarbon receptor (AhR) in skin physiology. They discuss the role of AhR in skin pathological processes, including inflammatory skin diseases, pigmentation disorders, and cancer. The impact of FICZ, kynurenic acid, and kynurenine on physiological and pathological processes in the skin is considered.
[International Journal of Molecular Sciences] |
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| Novan, Inc. announced it has completed patient enrollment in the B-SIMPLE4 pivotal Phase III clinical study of SB206, a topical antiviral gel, for the treatment of molluscum contagiosum.
[Novan, Inc.] |
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| VYNE Therapeutics, Inc. announced approval by the FDA to include new information in the product label for minocycline topical foam, 4% referencing the low propensity of P. acnes strains to develop resistance to minocycline, the active ingredient in AMZEEQ®.
[VYNE Therapeutics, Inc.] |
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| March 2 – 3, 2021
Virtual |
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| | Technical University of Denmark – Lyngby, Denmark |
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| | Karolinska Institutet – Solna, Sweden |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | Novo Nordisk – Copenhagen, Denmark |
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