 | | Vol. 7.05 – 8 February, 2021 |
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| Researchers showed that epidermal genes, including ~30% of induced differentiation genes already contain stalled Pol II at the promoters in epidermal stem and progenitor cells which was then released into productive transcription elongation upon differentiation.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
| | Through live imaging of organotypic cultures of the human epidermis, investigators found that regulated breakdown of mitochondria was critical for epidermal development.
[Cell Reports] |
| | Researchers introduced a nanofibrous wound dressing as a new strategy for a topical drug-delivery system.
[International Journal of Biological Macromolecules] |
| | The authors fabricated a hollow microneedle device consisting of an array and a reservoir by means of 3D printing technology for transdermal peptide delivery. The cytocompatibility of the microneedle arrays was assessed to human keratinocytes.
[International Journal of Pharmaceutics] |
| | Scientists analyzed the effect of phytocannabinoid-cannabinoid on the proteome of UVA/B irradiated keratinocytes.
[International Journal of Molecular Sciences] |
| | In vivo, epithelial cell sheets were directly transplanted to skin defect models and histological examination was performed at one week postoperatively.
[BMC Biotechnology] |
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| The authors found that there were multiple ETS family members expressed in melanoma and that these factors had redundant functions.
[Cancer Research] |
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| Investigators used a microfluidic platform to evaluate the cross-talk between human primary melanoma cells, keratinocytes and dermal fibroblasts.
[Lab on a Chip] |
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| Researchers investigated the role of lncRNA MIR205HG in melanomagenesis. Quantitative real-time PCR analysis showed that MIR205HG levels were significantly upregulated in melanoma cell lines compared to normal human melanocytes.
[Aging] |
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| Investigators evaluated the effects of a nano-clays mix on melanoma cell proliferation and cell viability in vitro and melanoma growth in vivo xenograft animal model.
[Scientific Reports] |
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| Scientists found that clones with knocked-out ACTBL2 or overexpressing actbl2 differed from control cells in the invasion, focal adhesion formation, and actin polymerization ratio, as well as in the formation of lamellipodia and stress fibers.
[Scientific Reports] |
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| Investigators outline the instances where aspects of an epithelial-mesenchymal transition (EMT) have been implicated in normal and neoplastic epithelial stem cells and consider the involvement of this programme during tissue regeneration and repair.
[Nature Reviews Cancer] |
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| The authors discuss the current state of the art of melanoma models including genetically engineered mouse, patient-derived xenograft, zebrafish, and ex vivo and in vitro models.
[Cancer Cell] |
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| Scientists describe the structure of the SARS-CoV-2 virus and relevant antigenic targets for vaccination, summarize key concepts of skin immunobiology in the context of prophylactic immunization, and present an overview of microarray patch-mediated cutaneous vaccine delivery.
[Advanced Drug Delivery Reviews] |
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| Tonix Pharmaceuticals Holding Corp. announced it has received the written response from the FDA to a Type B pre-investigational new drug meeting package describing its technology and plans to develop a diagnostic skin test, TNX-2100, to measure the delayed-type hypersensitivity reaction to SARS-CoV-2.
[Tonix Pharmaceuticals Holding Corp.] |
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| Arcutis Biotherapeutics, Inc. announced positive topline results from the DERMIS-1 and DERMIS-2 pivotal Phase III studies evaluating ARQ-151 as a potential topical treatment for plaque psoriasis. Roflumilast cream is a once daily topical formulation of roflumilast, a highly potent and selective phosphodiesterase type 4 inhibitor.
[Arcutis Biotherapeutics, Inc.] |
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| March 24 – 26, 2021
Virtual |
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| | University of Washington – Seattle, Washington, United States |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | Technical University of Denmark – Lyngby, Denmark |
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| | Karolinska Institutet – Solna, Sweden |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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