 | | Vol. 7.07 – 1 March, 2021 |
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| Seventeen key drivers of the gene subnetworks associated with poor prognosis, including the transcription factor ZNF180, were tested for their pro-tumorigenic effects in vitro. The anti-tumor effect of silencing ZNF180 was further validated using in vivo xenografts.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| IMD-0354 was confirmed as a potent inhibitor of glutamine uptake that attained sustained low intracellular glutamine levels. Concomitant with its inhibition of glutamine uptake, IMD-0354 attenuated mTOR signaling, suppressed 2D and 3D growth of melanoma cells, and induced cell cycle arrest, autophagy and apoptosis.
[Molecular Cancer Therapeutics] |
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| Knocking down CREB-binding protein or Ku70 induced necrotic and paraptotic cell death as indicated by high-level intracellular reactive oxygen species, cytoplasmic vacuolization, and cell cycle arrest in the S phase.
[Cell Death Discovery] |
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| Investigators transfected si-PLA2G4B in a murine keratinocyte cell-line PAM212 to verify the effect of progression by PLA2G4B.
[Experimental Biology and Medicine] |
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| To support the discovery of new drug candidates for melanoma, scientists examined 180 metabolic modulators, including phytochemicals and anti-diabetic compounds, for their growth-inhibitory activities against melanoma cells, alone and in combination with the BRAF inhibitor vemurafenib. 4-methylumbelliferone and ursolic acid, were subjected to validation and further characterization.
[Scientific Reports] |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| In vitro, cyclic mechanical stretch (CMS) increased Piezo1 expression and Piezo1-mediated calcium influx in human dermal fibroblasts (HDFs). Piezo1 activity promoted HDF proliferation, motility, and differentiation in response to CMS. Intradermal injection of GsMTx4, a Piezo1-blocking peptide, protected rats from stretch-induced hypertrophic scar formation.
[Cell Death & Disease] |
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| Scientists showed that aged hair follicle stem cells present with a decrease in canonical Wnt signaling and a shift towards non-canonical Wnt5a drove signaling which antagonized canonical Wnt signaling.
[Aging] |
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| Researchers showed that TX100-induced plasma membrane damage and death by necroptosis were both attenuated by surfactant polymer dressing, allowing keratinocyte survival.
[Scientific Reports] |
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| The extraction conditions of Nostoc commune Vauch polysaccharide (NCVP) were optimized by single factor and orthogonal experiments. Then, microcapsules (NCVPM) were prepared. After analyzing the microcapsule structural and thermal characteristics, the skin wound healing ability was studied by establishing back trauma rat models.
[Biomedical Materials] |
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| The authors summarize the current cell therapies used in skin regeneration with a focus on the importance of vascularization and recent progress in 3D fabrication approaches to generate vascularized network in the skin tissue graft.
[Journal of Translational Medicine] |
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| MediWound Ltd. announced the initiation of a new clinical development program to evaluate its drug product candidate MWPC005 in patients with non-melanoma skin cancer.
[MediWound Ltd.] |
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| | University of British Columbia – Vancouver, British Columbia, Canada |
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| | The Wistar Institute – Philadelphia, Pennsylvania, United States |
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| | University of Dundee – Dundee, Scotland, United Kingdom |
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| | University of Washington – Seattle, Washington, United States |
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| | Portland VA Research Foundation – Portland, Oregon, United States |
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