Dermal Cell News Volume 7.11 | Mar 29 2021

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    2021-03-29| DCN 7.11


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.11 – 29 March, 2021
    TOP STORY

    Interaction of the NRF2 and p63 Transcription Factors Promotes Keratinocyte Proliferation in the Epidermis

    The authors discovered an unexpected interaction between the cytoprotective transcription factor NRF2 and p63- a key player in epithelial morphogenesis.
    [Nucleic Acids Research]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Genetic Deletion of Nox4 Enhances Cancerogen-Induced Formation of Solid Tumors

    By identifying NADPH oxidase 4 (Nox4) as a protective source of reactive oxygen species (ROS) in cancerogen-induced cancer, researchers provided a piece of knowledge for understanding the role of moderate production of ROS in preventing the initiation of malignancies.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    A
    Role for Keratin 17 during DNA Damage Response and Tumor Initiation

    K17 occurs in the nucleus of human and mouse tumor keratinocytes where it impacts chromatin architecture, gene expression, and cell proliferation. Scientists reported that K17 is induced following DNA damage and promotes keratinocyte survival.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    A Protective Role for Autophagy in Vitiligo

    Researchers provide the first evidence that autophagy occured in melanocytes and fibroblasts from non-lesional skin of vitiligo patients, as a result of metabolic surveillance response.
    [Cell Death & Disease]

    Full Article

    Restoration of the Healing Microenvironment in Diabetic Wounds with Matrix-Binding IL-1 Receptor Antagonist

    Investigators demonstrated that matrix-binding IL-1 receptor antagonist improved wound healing in diabetic mice by re-establishing a pro-healing microenvironment characterized by lower levels of pro-inflammatory cells, cytokines and senescent fibroblasts, and higher levels of anti-inflammatory cytokines and growth factors.
    [Communications Biology]

    Full Article

    A Role for Dynlt3 in Melanosome Movement, Distribution, Acidity and Transfer

    The level of Dynlt3 is dependent on β-catenin activity, revealing a function of the Wnt/β-catenin signaling pathway during melanocyte and skin pigmentation, by coupling the transport, positioning and acidity of melanosomes required for their transfer.
    [Communications Biology]

    Full Article

    In Vitro Skin Culture Media Influence the Viability and Inflammatory Response of Primary Macrophages

    Scientists showed that skin maturation was affected by culture in macrophage medium, while macrophages showed reduced viability, altered cell morphology and decreased response to pro- and anti-inflammatory stimuli in skin differentiation media, both in 2D and 3D.
    [Scientific Reports]

    Full Article

    MicroRNA-125a Correlates with Decreased Psoriasis Severity and Inflammation and Represses Keratinocyte Proliferation

    Researchers investigated the correlation of miR-125a with disease severity and inflammation in psoriasis patients, and the effect of miR-125a on proliferation, apoptosis as well as its target signaling pathway in keratinocytes.
    [Dermatology]

    Abstract

    Establishment and Characterization of Fibroblast Cultures Derived from a Female Common Hippopotamus (Hippopotamus amphibius) Skin Biopsy

    Investigators established and characterized fibroblast cell cultures from the skin sample of a newborn common hippopotamus in this study.
    [Cell Biology International]

    Abstract

    LncRNA NORAD Engages in Psoriasis by Binding to miR-26a to Regulate Keratinocyte Proliferation

    The authors investigated the role of non-coding RNA-activated by DNA damage (NORAD) in the development of psoriasis.
    [Autoimmunity]

    Abstract
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    REVIEWS

    Scaffold-Free Cell-Based Tissue Engineering Therapies: Advances, Shortfalls and Forecast

    Scientists critically discuss advancements and shortfalls of scaffold-free cell-based tissue engineering strategies, along with pioneering concepts that have the potential to transform regenerative and reparative medicine.
    [NPJ Regenerative Medicine]

    Full Article

    Epithelial Plasticity, Epithelial-Mesenchymal Transition, and the TGF-β Family

    The authors discuss roles of TGF-β and TGF-β-related proteins, and underlying molecular mechanisms, in epithelial plasticity in development and wound healing, fibrosis, and cancer.
    [Developmental Cell]

    Abstract
    INDUSTRY AND POLICY NEWS

    Arcutis Announces First Patient Enrolled in Phase IIa Clinical Trial Evaluating ARQ-252 as a Potential Treatment for Vitiligo

    Arcutis Biotherapeutics, Inc. announced enrollment of the first patient in a Phase IIa clinical trial evaluating ARQ-252 as a potential treatment for vitiligo. ARQ-252 is a potent and highly selective topical small molecule inhibitor of Janus kinase type 1.
    [Arcutis Biotherapeutics, Inc.]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Long-Distance Cell-Cell Signaling in Development and Disease

    September 5 – 8, 2021
    Exeter, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Medicinal Chemist – Muscle-Wasting, Neurodegeneration, and Oncology

    Almac – Belfast, Ireland

    Associate Researcher – Developmental and Regenerative Biology

    Mount Sinai Health System – New York, New York, United States

    Postdoctoral Fellow – Diet and Melanoma

    MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Fellow – Signaling Pathways and Melanoma

    The Wistar Institute – Philadelphia, Pennsylvania, United States

    Postdoctoral Scholar – Immune Responses in Human Skin and Mucosal Surfaces

    University of Washington – Seattle, Washington, United States

    > See All Jobs

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