Dermal Cell News Volume 7.13 | Apr 12 2021

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    Justin.choi
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    2021-04-12 | DCN 7.13


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.13 – 12 April, 2021
    TOP STORY

    Female Immunity Protects from Cutaneous Squamous Cell Carcinoma

    Researchers published data showing women presented less aggressive primary cutaneous squamous cell carcinoma and early strong immune activation.
    [Clinical Cancer Research]

    Abstract
    Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.

    Functional Cooperation between ASK1 and p21Waf1/Cip1 in the Balance of Cell-Cycle Arrest, Cell Death and Tumorigenesis of Stressed Keratinocytes

    Scientists observed that deletion of p21 Waf1/Cip1 led to increased keratinocyte proliferation but also increased cell death.
    [Cell Death Discovery]

    Full Article

    Activation of Matrix Metalloproteinases and FoxO3a in HaCaT Keratinocytes by Radiofrequency Electromagnetic Field Exposure

    The authors evaluated the use and trends of active comparator trial designs in dermatology.
    [Scientific Reports]

    Full Article

    Abundance and Size of Hyaluronan in Naked Mole-Rat Tissues and Plasma

    Researchers examined hyaluronan (HA) metabolism in rodents closely. HA was localized and quantified using HA binding proteins.
    [Scientific Reports]

    Full Article

    MrgprC11+ Sensory Neurons Mediate Glabrous Skin Itch

    Investigators developed a mouse glabrous skin behavioral assay to investigate the contribution of three previously identified pruriceptive neurons in glabrous skin itch.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Epigenetic Reprogramming of Tumor Cell–Intrinsic STING Function Sculpts Antigenicity and T Cell Recognition of Melanoma

    Scientists showed that promoter hypermethylation of cGAS and stimulator of interferon genes (STING) mediated their coordinated transcriptional silencing and contributed to the widespread impairment of the STING signaling function in clinically-relevant human melanomas and melanoma cell lines.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    CSDE1 Attenuates MicroRNA-Mediated Silencing of PMEPA1 in Melanoma

    Scientists showed that PMEPA1 promoted tumorigenic traits and that CSDE1 along with miR-129-5p/AGO2 miRISC acted antagonistically to fine-tune PMEPA1 expression toward the progression of melanoma.
    [Oncogene]

    Abstract

    Myeloid Cell–Derived HOCl Is a Paracrine Effector That Trans-inhibits IKK/NF-κB in Melanoma Cells and Limits Early Tumor Progression

    Investigators revealed a role for myeloid-derived cells-derived hypochlorous acid (HOCl) as a small-molecule paracrine signaling factor that trans-inhibited inhibited IκB kinase (IKK) in melanoma tumor cells, mediating antitumor responses during early tumor progression.
    [Science Signaling]

    Abstract

    Complement Factor I Upregulates Expression of Matrix Metalloproteinase‐13 and ‐2 and Promotes Invasion of Cutaneous Squamous Carcinoma Cells

    The authors studied the functional role of complement factor I (CFI) in the progression of cutaneous squamous cell carcinoma (cSCC). CFI was knocked down in cSCC cells and RNA‐seq analysis was performed.
    [Experimental Dermatology]

    Abstract
    Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.
    REVIEWS

    Use of Active Comparator Trials for Topical Medications in Dermatology

    Some new medications may improve patient outcomes, others may not offer meaningful benefits vs existing less costly alternatives, especially in dermatology, in which subtle changes in the concentration or combination of topical agents can be classified as a novel product.
    [JAMA Dermatology]

    Abstract

    Paracrine Regulation of Keratinocyte Proliferation and Differentiation

    The authors review exciting recent findings on the identification, regulation and function of paracrine-acting cytokines in the skin.
    [Trends in Cell Biology]

    Abstract

    INDUSTRY AND POLICY NEWS

    AbbVie Announces Extension of Review for Supplemental New Drug Application of Upadacitinib for the Treatment of Moderate to Severe Atopic Dermatitis

    AbbVie announced that the US FDA has extended the review period for the supplemental New Drug Application for upadacitinib in the treatment of adults and adolescents with moderate to severe atopic dermatitis.
    [AbbVie (PRNewswire)]

    Press Release

    Pfizer Announces Extension of Review of New Drug Application of Abrocitinib for the Treatment of Moderate to Severe Atopic Dermatitis

    Pfizer, Inc. announced that the US FDA has extended the priority review period for the New Drug Application for abrocitinib for the treatment of adults and adolescents with moderate to severe atopic dermatitis.
    [Pfizer Inc. (businesswire)]

    Press Release
    FEATURED EVENT

    6th World Congress of the Tissue Engineering and Regenerative Medicine International Society

    November 15 – 19, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Immunology Focusing on the Skin

    Karolinska Institutet (KI) – Stockholm, Sweden

    Research Specialist – Skin Stem Cells

    Howard Hughes Medical Institute – New York, New York, United States

    Associate Researcher – Developmental and Regenerative Biology

    Mount Sinai Health System – New York, New York, United States

    Postdoctoral Fellow – Diet and Melanoma

    MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Fellow – Signaling Pathways and Melanoma

    The Wistar Institute – Philadelphia, Pennsylvania, United States

    > See All Jobs

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