Dermal Cell News Volume 7.15 | Apr 26 2021

Preventing Engrailed-1 Activation in Fibroblasts Yields Wound Regeneration without Scarring

Vol. 7.15 – 26 April, 2021 TOP STORY Preventing Engrailed-1 Activation in Fibroblasts Yields Wound Regeneration without Scarring Scientists used fibroblast transplantation as well as transgenic mouse models to trace expression in a spatiotemporally defined fashion. [Science] AbstractGraphical Abstract PUBLICATIONSRanked by the impact factor of the journal DERMAL STEM CELLS & TISSUE REGENERATION CD44v6-Targeted CAR T-Cells Specifically Eliminate CD44 Isoform 6 Expressing Head/Neck Squamous Cell Carcinoma Cells Investigators established a highly specific chimeric antigen receptors (CAR) against CD44v6 on head and neck squamous cell carcinoma cells that could be expressed on normal T-cells with lentiviral vectors. [Oral Oncology] Abstract Senescent Cell Removal via JAG1-NOTCH1 Signaling in the Epidermis Researchers hypothesized that there was a mechanism by which senescent cells in the epidermis were preferentially removed and that the function of such removal mechanism declined as age increased. [Experimental Dermatology] Abstract HEATR1, a Novel Interactor of Pontin/Reptin, Stabilizes Pontin/Reptin and Promotes Cell Proliferation of Oral Squamous Cell Carcinoma The authors identified HEAT repeat-containing protein 1 (HEATR1) as a novel binding factor of Pontin/Reptin. [Biochemical and Biophysical Research Communications] Abstract IGF-1-Expressing Placenta-Derived Mesenchymal Stem Cells Promote Scalding Wound Healing Scientists investigated the effect of insulin-like growth factor-1 (IGF-1)-expressing placenta-derived mesenchymal stem cells on healing of burn wounds. [Journal of Surgical Research] Abstract SKIN CANCERS & DISORDERS LINC00470 Accelerates the Proliferation and Metastasis of Melanoma through Promoting APEX1 Expression Researchers investigated the role of LINC00470 in the development of melanoma. They discovered that LINC00470 was overexpressed in melanoma tissues and cells compared with the adjacent normal tissues and cells by qPCR. [Cell Death & Disease] Full Article Exploring the Dermotoxicity of the Mycotoxin Deoxynivalenol: Combined Morphologic and Proteomic Profiling of Human Epidermal Cells Reveals Alteration of Lipid Biosynthesis Machinery and Membrane Structural Integrity Relevant for Skin Barrier Function To investigate the potential dermotoxicity of deoxynivalenol (DON), epidermoid squamous cell carcinoma cells A431 were compared to primary human neonatal keratinocytes (HEKn) cells via proteome/phosphoproteome profiling. [Archives of Toxicology] Full Article Prion Protein Is Associated with a Worse Prognosis of Head and Neck Squamous Cell Carcinoma Scientists investigated hypoxia’s effect in lymph node metastasis by prion protein expression changes and its main partners. [Journal of Oral Pathology & Medicine] Abstract REVIEWS Autoreactive T Cells and Their Role in Atopic Dermatitis The authors evaluate the development of (autoreactive) T cells and their response to (auto)antigens, as well as the role of the peripheral tolerance in autoimmunity in the pathophysiology of atopic dermatitis, including the unmet needs and gaps. [Journal of Autoimmunity] Abstract INDUSTRY AND POLICY NEWS Onconova Announced First Patient Dosed in Investigator-Initiated Phase II Study of Rigosertib in Recessive Dystrophic Epidermolysis Bullosa-Associated Squamous Cell Carcinoma Onconova Therapeutics, Inc., announced that the first patient has been dosed in an investigator-initiated Phase II study to assess the efficacy and safety of rigosertib in patients with recessive dystrophic epidermolysis bullosa-associated locally advanced/metastatic squamous cell carcinoma. [Onconova Therapeutics, Inc. (Globe Newswire, Inc.)] Press Release Bristol Myers Squibb Presents Positive Data from Two Pivotal Phase III Psoriasis Studies Demonstrating Superiority of Deucravacitinib Compared to Placebo and Otezla® Bristol Myers Squibb announced positive results from two pivotal Phase III trials evaluating deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, for the treatment of patients with moderate to severe plaque psoriasis. [Bristol Myers Squibb (Business Wire, Inc.)] Press Release FEATURED EVENT ISSCR: Stem Cells and Regenerative Medicine January 12 – January 14, 2022 Shanghai, China > See All Events JOB OPPORTUNITIES Research Specialist – Skin Stem Cells Howard Hughes Medical Institute – New York, New York, United States Postdoctoral Fellow – Wound Healing UCLA – Los Angeles, California, United States Postdoctoral Fellow – Skin Immunology University of Maryland – Maryland, Baltimore, United States Postdoctoral Fellow – Diet and Melanoma MD Anderson Cancer Center – Houston, Texas, United States Academic Dermatopathologist – Diagnostics and Research Brigham and Women’s Hospital – Boston, MA, United States > See All Jobs Brought to you by Science News Dermal Cell News Archives Contact Us