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| Scientists found that BNIP3‐deprived melanoma cells displayed increased intracellular iron levels caused by heightened NCOA4‐mediated ferritinophagy, which fostered PHD2‐mediated HIF‐1α destabilization.
[EMBO Journal] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Researchers found that upper stratum granulosum cell death was preceded by prolonged Ca2+ elevation and rapid induction of intracellular acidification.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists found that Tmem79−/− mice spontaneously developed interleukin-17-producing T-cell-driven skin inflammation. Comparative skin microbiome analysis revealed that the disease activity index was negatively associated with S. cohnii.
[Cell Reports] |
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| β-glucan was studied as a healing biomaterial that had not been reported in the scientific literature. LAS produced by the ascomycete Lasiodiplodia theobromae MMPI was used in the formulation of a healing hydrogel.
[International Journal of Biological Macromolecules] |
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| In order to elucidate the inhibitory effects of cycloheterophyllin on the B16F10 cell line, cell viability, messenger ribonucleic acid expressions, tyrosinase activity assay, and melanin production assay were measured.
[Molecules] |
| |
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| Scientists found that the expression of ITIH5 was decreased in melanoma tissues compared with normal skin tissues.
[Cell Death & Disease] |
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| Researchers demonstrated restricted skin exposure of RORγ antagonist might provide a new topical treatment option as targeted therapeutics for mild to moderate psoriasis patients and might be suitable for the treatment of any other inflammatory disorders that are accessible locally.
[Scientific Reports] |
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| The authors showed that Sanger sequencing using the NuProbe VarTrace BRAF assay, based on the Blocker Displacement Amplification technology, was capable of detecting BRAF V600 mutations down to 0.20% VAF from FFPE lymph node tissue samples.
[Scientific Reports] |
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| Researchers evaluated patient demographics, stages, clinicopathological features, anatomic site of melanoma including nail versus volar surface, and degree of melanoma pigmentations, sentinel lymph node biopsy results, and the first metastasis sites.
[Pigment Cell & Melanoma Research] |
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| Investigators characterized the molecular profile of squamous cell carcinoma by developing a classification system based on DNA damage repair gene expression profiles.
[Life Sciences] |
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| Researchers give current insight into studies combining systemic and local therapeutic approaches to overcome drug resistance, prime melanoma cells for therapy, and improve overall treatment response in cutaneous melanoma patients.
[Cancers] |
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| | The authors review both beneficial and detrimental functions of skin mast cells (MC), from skin barrier integrity via host defense mechanisms to MC-driven inflammatory skin disorders.
[International Journal of Molecular Sciences] |
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| Teva Pharmaceuticals, Inc. announced its launch of the first available 10 mg, 20 mg, 25 mg, 30 mg, 35 mg and 40 mg strength generic version of Absorica®1 capsules for the treatment of severe recalcitrant nodular acne in non-pregnant patients 12 years of age and older with multiple inflammatory nodules with a diameter of 5 mm or greater.
[Teva Pharmaceuticals, Inc. (Business Wire, Inc.)] |
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| Melinta Therapeutics, Inc. and Hikma Pharmaceuticals PLC, Inc. announced that they have entered into an exclusive licensing agreement for Vabomere® and Orbactiv®, two novel anti-infective injectable products, for the Middle East and North Africa region.
[Melinta Therapeutics, Inc. (Business Wire, Inc.)] |
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| May 25 – 27, 2022
Hinxton, England, United Kingdom |
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| | Harvard Medical School – Boston, MA, United States |
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| | University of Maryland – Baltimore, United States |
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| | UCLA – Los Angeles, California, United States |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| | Howard Hughes Medical Institute – New York, New York, United States |
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