Dermal Cell News Volume 7.19 | May 31 2021

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    Dermal Cell News by STEMCELL Technologies
    Vol. 7.19 – 31 May, 2021
    TOP STORY

    Photobiomodulation Therapy for Hair Regeneration: A Synergetic Activation of β-CATENIN in Hair Follicle Stem Cells by ROS and Paracrine WNTs

    Photobiomodulation therapy was found to drive quiescent hair follicle stem cell activation and alleviate hair follicle atrophy.
    [Cell Stem Cell]

    Full Article

    Explore scientific events this June with the Science Events Calendar.
    PUBLICATIONSRanked by the impact factor of the journal

    High Proliferation and Delamination during Skin Epidermal Stratification

    Scientists used centrosomes, that organize the mitotic spindle, to test whether cell division orientation and stratification are linked.
    [Nature Communications]

    Full Article

    Keratinocyte-Derived Microvesicle Particles Mediate Ultraviolet B Radiation–Induced Systemic Immunosuppression

    Researchers used both pharmacologic and genetic approaches in cells and mice to show that both the platelet-activating factor receptor and enzyme acid sphingomyelinase were necessary for Ultraviolet B – micro vesicle particle generation.
    [Journal of Clinical Investigation]

    Full ArticleGraphical Abstract

    Integrated Metabolomic Analysis and Cytokine Profiling Define Clusters of Immuno-Metabolic Correlation in New-Onset Psoriasis

    Researchers analyzed the metabolic and cytokine/chemokine profiles in serum and skin from patients with new-onset psoriasis and healthy subjects by HR-MAS NMR and Bio-Plex immunoassay.
    [Scientific Reports]

    Full Article

    Longitudinal Profiling of the Burn Patient Cutaneous and Gastrointestinal Microbiota: A Pilot Study

    Scientists found significant reduction in alpha diversity on the burn wound compared to spared skin throughout the sampling period as well as reduction in common skin commensal bacteria such as Propionibacterium acnes and Staphylococcus epidermitis.
    [Scientific Reports]

    Full Article

    Ultraviolet Radiation Protection Potentials of Methylene Blue for Human Skin and Coral Reef Health

    Investigators tested the effects of Methylene blue on UVB ray-induced DNA double-strand breaks in primary human keratinocytes.
    [Scientific Reports]

    Full Article

    Decellularized Dermis Extracellular Matrix Alloderm Mechanically Strengthens Biological Engineered Tunica Adventitia-Based Blood Vessels

    Researchers evaluated the commercially-available decellularized skin dermis ECM Alloderm for efficacy in providing structure to biological engineered blood vessels.
    [Scientific Reports]

    Full Article

    The Protective Role of MC1R in Chromosome Stability and Centromeric Integrity in Melanocytes

    Investigators demonstrated that melanocortin-1 receptor (MC1R) was a critical factor in chromosome stability and centromere integrity in melanocytes. α-MSH/MC1R stimulation prevented melanocytes from UV radiation-induced damage of chromosome stability and centromere integrity.
    [Cell Death Discovery]

    Full Article

    Antitumor Effect of Melaleuca alternifolia Essential Oil and Its Main Component Terpinen-4-Ol in Combination with Target Therapy in Melanoma Models

    When combined with dabrafenib and/or trametinib, Melaleuca alternifolia synergistically reduced the viability of melanoma cells by activating apoptosis.
    [Cell Death Discovery]

    Full Article

    Acid Ceramidase Controls Apoptosis and Increases Autophagy in Human Melanoma Cells Treated with Doxorubicin

    Investigators found that doxorubicin activates the autophagic response in wild-type A375 cells, which effectively resisted apoptotic cell death.
    [Scientific Reports]

    Full Article

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    REVIEWS

    The Promise and Challenges of Cell Therapy for Psoriasis

    The authors discuss the various forms of cell therapy currently available, their utility in the management of immune-mediated inflammatory diseases and emerging evidence for efficacy in severe psoriasis unresponsive to biologic therapy.
    [British Journal of Dermatology]

    Full Article

    Distinct Fibroblasts in Scars and Regeneration

    The authors discuss the distinct embryonic origins, microenvironments, and transcriptomic profiles of fibroblastic lineages, and how these varying lineages shape the skin’s wound response across injury depths, anatomic locations, and developmental time to promote either scarring or regeneration.
    [Current Opinion in Genetics & Development]

    Full Article

    INDUSTRY AND POLICY NEWS

    Six-and-a-Half-Year Outcomes for Opdivo (Nivolumab) in Combination with Yervoy (Ipilimumab) Continue to Demonstrate Durable Long-Term Survival Benefits in Patients with Advanced Melanoma

    Bristol Myers Squibb, Inc. announced new six-and-a-half-year data from CheckMate -067, a randomized, double-blind, Phase III clinical trial, demonstrating durable improvement in survival with first-line Opdivo (nivolumab) plus Yervoy (ipilimumab) therapy and Opdivo monotherapy, versus Yervoy alone, in patients with advanced melanoma.
    [Bristol Myers Squibb, Inc. (Business Wire, Inc.)]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Lactate Unconventional Roles of a Nutrient Along Tumor Landscape

    June 21 -23, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cutaneous Biology

    University of Michigan – Ann Arbor, Michigan, United States

    Principal Bioinformatician – Skin Cancers

    Wellcome Trust Sanger Institute – Cambridge, England, United Kingdom

    Group Leader – Skin Immunology

    University of Copenhagen – Copenhagen, Denmark

    Postdoctoral Fellow – Wound Healing

    UCLA – Los Angeles, California, United States

    Postdoctoral Fellow – Functional Genomics and Epigenomic Regulation

    National Institutes of Health – Bethesda, Maryland, United States

    > See All Jobs

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