Dermal Cell News Volume 7.21 | Jun 14 2021

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    Justin.choi
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    2021-06-14 | DCN 7.21


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.21 – 14 June, 2021
    TOP STORY

    Tracing the Origin of Hair Follicle Stem Cells

    Investigators combined marker-independent long-term 3D live imaging and single-cell transcriptomics to capture a dynamic lineage progression and transcriptome changes in the entire epithelium of the mouse hair follicle as it developed.
    [Nature]

    Abstract

    PUBLICATIONSRanked by the impact factor of the journal

    miR-24 Controls the Regenerative Competence of Hair Follicle Progenitors by Targeting Plk3

    Researchers explored how the intrinsic sensitivity of skin hair follicle (HF) progenitors to growth stimuli was dynamically regulated. They discovered miR-24 was an miRNA whose expression in HF progenitors inversely correlated with their growth potency in vivo.
    [Cell Reports]

    Full Article

    Skin Protein-Derived Peptide-Conjugated Vesicular Nanocargos for Selected Skin Cell Targeting and Consequent Activation

    Investigators selectively conjugated several skin protein-derived cell-targeting peptides, including KTTKS, NAP-amide, and Lam332, to amphiphilic polymer-reinforced lipid nanovesicles to specifically target fibroblasts, melanocytes, and keratinocytes, respectively, through effective association with the corresponding cell membrane receptors.
    [Journal of Materials Chemistry B]

    Abstract

    Novel Induction of CD40 Expression by Tumor Cells with RAS/RAF/PI3K Pathway Inhibition Augments Response to Checkpoint Blockade

    Rigosertib monotherapy or in combination therapy with immune checkpoint blockade were investigated using immunocompetent mouse models of BRAFwt and BRAFmut melanoma and analyzed in reference to patient data.
    [Molecular Cancer]

    Full Article

    Dual Covalent Inhibition of PKM and IMPDH Targets Metabolism in Cutaneous Metastatic Melanoma

    Scientists identified a drug, HA344, that concomitantly targeted two distinct metabolic hubs in cancer cells.
    [Cancer Research]

    Abstract

    Inhibitory Effect of Saccharomyces cerevisiae Extract Obtained through Ultrasound-Assisted Extraction on Melanoma Cells

    Ultrasound-assisted extract of yeast was found to effectively inhibit melanoma cell growth and proliferation as well as the expression of cyclin D1 and c-myc, in vitro.
    [Ultrasonics Sonochemistry]

    Full Article

    Epidermal Stem Cells Maintain Stemness via a Biomimetic Micro/Nanofiber Scaffold That Promotes Wound Healing by Activating the Notch Signaling Pathway

    To inhibit the differentiation of epidermal stem cells (EpSCs) and maintain their stemness, scientists developed an electrospun polycaprolactone + cellulose acetate micro/nanofiber for the culture and transplantation of EpSCs.
    [Stem Cell Research & Therapy]

    Full Article

    Suppressive Role of microRNA-130b-3p in Ferroptosis in Melanoma Cells Correlates with DKK1 Inhibition and Nrf2-HO-1 Pathway Activation

    Researchers identified whether and how miR-130b-3p regulated ferroptosis in melanoma cells. Melanoma cells were treated with erastin or RSL3 to mimic ferroptosis in vitro.
    [Human Cell]

    Abstract

    Rapid, Quantitative Prediction of Tumor Invasiveness in Non-Melanoma Skin Cancers Using Mechanobiology-Based Assay

    Cells from 15 fresh tissue samples of suspected non-melanoma skin cancer were seeded on physiological-stiffnesssynthetic gels, and within one hour invasive cell subsets were observed to push/indent the gel surface; clinicopathological results were separately obtained using standard protocols.
    [Biomechanics and Modeling in Mechanobiology]

    Abstract

    REVIEWS

    Diving into 3D (Bio)Printing: A Revolutionary Tool to Customize the Production of Drug and Cell-Based Systems for Skin Delivery

    The potential of 3D bioprinting for skin applications is presented, highlighting the development of patch-like skin constructs for wound and burn treatment, and skin equivalents for in vitro research and drug development.
    [International Journal of Pharmaceutics]

    AbstractGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Sorrento Announces Clinical Research Agreement With Mayo Clinic and FDA Clearance for the First Phase Ib Pilot Study Using Sofusa Lymphatic Drug Delivery Technology to Deliver Ipilimumab in Patients With Melanoma

    Sorrento Therapeutics, Inc. announced a research collaboration agreement with Mayo Clinic to conduct human clinical proof of concept studies using the Sofusa Lymphatic Drug Delivery System technology across multiple products and indications.
    [Sorrento Therapeutics, Inc.]

    Press Release

    Istari Oncology Announces FDA Granted Fast Track Designation to PVSRIPO for the Treatment of Advanced Melanoma

    Istari Oncology, Inc., announced that the US FDA has granted Fast Track designation to PVSRIPO for the improved survival in patients with advanced melanoma who have disease progression after anti-PD-1/anti-PD-L1 therapy.
    [Istari Oncology, Inc. (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    Till & McCulloch Meeting 2021

    November 15 – 17, 2021
    Ottawa, Ontario, Canada

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Immunology or Bacteriology

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Associate/Full Professor – Cancers or Cancer Immunotherapy

    University of Hawaii Cancer Center – Honolulu, Hawaii, United States

    Postdoctoral Researcher – Skin/Tissue Adhesive

    Ulsan National Institute of Science and Technology – Ulsan, South Korea

    Postdoctoral Fellow – Cutaneous Biology

    University of Michigan – Ann Arbor, Michigan, United States

    Principal Bioinformatician – Skin Cancers

    Wellcome Trust Sanger Institute – Cambridge, England, United Kingdom

    > See All Jobs

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