Dermal Cell News Volume 7.23 | Jun 28 2021

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    2021-06-28 | DCN 7.23


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.23 – 28 June, 2021
    TOP STORY

    Dominant Effect of Gap Junction Communication in Wound-Induced Calcium-Wave, NFAT Activation and Wound Closure in Keratinocytes

    Real-time cell migration analysis, measuring wound closure rates over 24 hours, revealed that 18αGA essentially blocked wound closure whereas hexokinase and GSK-7975A showed relatively minimal effects.
    [Journal of Cellular Physiology]

    Abstract

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    Staphylococcus aureus Impairs Dermal Fibroblast Functions with Deleterious Effects on Wound Healing

    Scientists investigated the potential effects of Staphylococcus aureus on dermal fibroblasts as key cells for tissue repair.
    [FASEB Journal]

    Full Article

    A New Microfluidic Method Enabling the Generation of Multi-Layered Tissues-on-Chips Using Skin Cells as a Proof of Concept

    Researchers presented for the first time, a novel approach to generate 3D multilayer tissue models in microfluidic platforms.
    [Scientific Reports]

    Full Article

    Combination of Retinoids and Narrow-Band Ultraviolet B Inhibits Matrix Metalloproteinase 13 Expression in HaCaT Keratinocytes and a Mouse Model of Psoriasis

    Scientists showed that patients with psoriasis had increased levels of matrix metalloproteinase13 protein in skin lesions and serum samples.
    [Scientific Reports]

    Full Article

    Accelerated Burn Wound Healing with Photobiomodulation Therapy Involves Activation of Endogenous Latent TGF-β1

    Researchers investigated the roles of individual cell types involved in burn wound healing following photobiomodulation treatments and noted discrete effects on epithelium, fibroblasts, and macrophage functions.
    [Scientific Reports]

    Full Article

    Dermal Mesenchymal Stem Cells from Psoriatic Lesions Stimulate HaCaT Cell Proliferation, Differentiation, and Migration via Activating the PI3K/AKT Signaling Pathway

    Scientists studied the effects of psoriatic dermal mesenchymal stem cells on the proliferation, differentiation, and migration of keratinocytes and the underlying mechanisms.
    [Dermatology]

    Abstract

    Circ_PRKDC Knockdown Promotes Skin Wound Healing by Enhancing Keratinocyte Migration via miR-31/FBN1 Axis

    The migration ability and the changes of matrix metallopeptidase 9 (MMP-9) and MMP2 levels were determined using wound healing, transwell and Western blot assays.
    [Journal of Molecular Histology]

    Abstract

    A Preclinical Pipeline to Evaluate Migrastatics as Therapeutic Agents in Metastatic Melanoma

    Experimentally, researchers performed in vitro target validation, developed a new traceable spontaneously metastasising murine melanoma model for in vivo validation, and employed histology to confirm drug action in harvested tumour tissues.
    [British Journal of Cancer]

    Full Article

    Melanoma Reactive TCR-Modified T Cells Generated without Activation Retain a Less Differentiated Phenotype and Mediate a Superior In Vivo Response

    Investigators demonstrated efficient T cell transduction with the melanoma-reactive TIL1383I TCR through culturing with interleukin 7 in the absence of CD3 activation.
    [Scientific Reports]

    Full Article

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    REVIEWS

    Unlocking the Potential of Induced Pluripotent Stem Cells for Wound Healing: The Next Frontier of Regenerative Medicine

    Since the last decade induced pluripotent stem cells has been revolutionizing the field of wound healing and skin tissue engineering. Despite the current progress, safety and heterogeneity among iPSC lines are still major hurdles in addition to the lack of large animal studies.
    [Advances in Wound Care]

    Abstract

    INDUSTRY AND POLICY NEWS

    BioNTech Announces First Patient Dosed in Phase II Clinical Trial of mRNA-Based BNT111 in Patients with Advanced Melanoma

    BioNTech SE announced that the first patient has been treated in its BNT111 Phase II cancer vaccine trial. The study was evaluating the Company’s therapeutic cancer vaccine candidate BNT111 in combination with Libtayo® in patients with anti-PD1-refractory/relapsed unresectable Stage III or IV melanoma.
    [BioNTech]

    Press Release

    Cutiss Develops World’s First Machine to Produce Personalized Human Skin Tissue Therapy

    CUTISS AG, a Swiss clinical-stage life sciences company focused on skin regenerative medicine and tissue engineering, has unveiled the world’s first automated machine to produce customized skin tissue grafts for adults and children with severe skin injuries, such as deep burns.
    [Cutiss, AG.]

    Press Release

    FEATURED EVENT

    ISSCR: Stem Cells – From Basic Science to Clinical Translation

    October 27 – 29, 2021
    Tokyo, Japan

    > See All Events

    JOB OPPORTUNITIES

    Professorship – Immunodermatology

    University of Erlangen-Nuremberg – Erlangen, Germany

    Postdoctoral Fellow – In-Situ Gene Therapy

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Fellow – Immunology or Bacteriology

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Associate/Full Professor – Cancers or Cancer Immunotherapy

    University of Hawaii Cancer Center – Honolulu, Hawaii, United States

    Postdoctoral Researcher – Skin/Tissue Adhesive

    Ulsan National Institute of Science and Technology – Ulsan, South Korea

    > See All Jobs

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