Dermal Cell News Volume 7.24 | Jul 05 2021

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    2021-07-05 | DCN 7.24


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.24 – 5 July, 2021
    TOP STORY

    The RNase MCPIP3 Promotes Skin Inflammation by Orchestrating Myeloid Cytokine Response

    Researchers reported that monocyte chemotactic protein-induced protein 3 (MCPIP3), promoted skin inflammation by simultaneously enhancing tumor necrosis factor in macrophages and repressing interleukin-6 in plasmacytoid dendritic cells.
    [Nature Communications]

    Full Article

    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    PUBLICATIONSRanked by the impact factor of the journal

    Insights into Antioxidant Activities and Anti-Skin-Aging Potential of Callus Extract from Centella asiatica (L.)

    The authors demonstrated that callus extract possessed promising antioxidant and anti-skin-aging activities. Pre-treatment with callus extract attenuated H2O2-induced-cytotoxicity on human dermal fibroblasts.
    [Scientific Reports]

    Full Article

    AP-2alpha-Mediated Activation of E2F and EZH2 Drives Melanoma Metastasis

    Researchers demonstrated that AP-2alpha facilitated melanoma metastasis through transcriptional activation of genes within the E2F pathway including EZH2.
    [Cancer Research]

    Abstract

    SFPQ Promotes an Oncogenic Transcriptomic State in Melanoma

    Investigators reported that knockdown of splicing factor, proline- and glutamine-rich (SFPQ) expression in melanoma cells decelerated several cancer-associated cell phenotypes, including cell growth, migration, epithelial to mesenchymal transition, apoptosis, and glycolysis.
    [Oncogene]

    Full Article

    Tumor Perfusion Evaluation Using Dynamic Contrast-Enhanced Ultrasound after Electrochemotherapy and IL-12 Plasmid Electrotransfer in Murine Melanoma

    Scientists evaluated the results of dynamic contrast-enhanced ultrasound as a predictive factor for electrochemotherapy with bleomycin and gene electrotransfer of plasmid DNA encoding IL-12 in murine melanoma.
    [Scientific Reports]

    Full Article

    LncRNA HCP5 Acts as a ceRNA to Regulate EZH2 by Sponging miR-138-5p in Cutaneous Squamous Cell Carcinoma

    Long non‑coding RNAs (lncRNAs) and miRNAs are essential for the progression of tumors, including cutaneous squamous cell carcinoma (CSCC). Researchers examined the competing endogenous RNA network in cutaneous squamous cell carcinoma.
    [International Journal of Oncology]

    Full Article

    Modified 5-Aminolevulinic Acid Photodynamic Therapy (M-PDT) Inhibits Cutaneous Squamous Cell Carcinoma Cell Proliferation via Targeting PP2A/PP5-Mediated MAPK Signaling Pathway

    Scientists unveiled the effect of M-PDT on cutaneous squamous cell carcinoma cell proliferation and the regulatory effect of M-PDT on MAPK signaling.
    [International Journal of Biochemistry & Cell Biology]

    Abstract

    LncRNA MSC-AS1 Motivates the Development of Melanoma by Binding to miR-302a-3p and Recruiting IGF2BP2 to Elevate LEF1 Expression

    The silencing of long non-coding RNAs (lncRNA) MSC antisense RNA 1 (MSC-AS1) hindered cell proliferation, migration and epithelial-mesenchymal transition in vitro and tumor growth in vivo.
    [Experimental Dermatology]

    Abstract

    CD36 Promotes Vasculogenic Mimicry in Melanoma by Mediating Adhesion to the Extracellular Matrix

    Human vasculogenic mimicry (VM)-competent melanoma cell lines were examined for their VM potential using the in vitro angiogenesis assays, together with inhibition studies using small interfering RNA and blocking monoclonal antibodies.
    [BMC Cancer]

    Full Article

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    REVIEWS

    Molecular Pathology of Skin Adnexal Tumors

    Investigators provide a comprehensive overview and update of the molecular findings associated with adnexal tumors of the skin.
    [Histopathology]

    Abstract|
    Graphical Abstract

    INDUSTRY AND POLICY NEWS

    Croma-Pharma Announces 9-Country Licensing Agreement with Crescita Therapeutics for Pliaglis®

    Croma-Pharma GmbH announced that it has entered into an exclusive commercialization development license agreement with Crescita Therapeutics for the rights to Pliaglis® in nine countries including Germany, the United Kingdom, Ireland, Switzerland, Brazil, Romania, Belgium, the Netherlands and Luxembourg.
    [Croma-Pharma GmbH]

    Press Release

    FEATURED EVENT

    EMBO: Molecular Mechanisms of Aging and Regeneration: From Hydra to Humans

    September 6 – 10, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Nanocellulose Electrodes

    KTH Royal Institute of Technology – Stockholm, Sweden

    Professorship – Immunodermatology

    University of Erlangen-Nuremberg – Erlangen, Germany

    Postdoctoral Fellow – In-Situ Gene Therapy

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Fellow – Immunology or Bacteriology

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Associate/Full Professor – Cancers or Cancer Immunotherapy

    University of Hawaii Cancer Center – Honolulu, Hawaii, United States

    > See All Jobs

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